期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 357, 期 18, 页码 4055-4062出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500680
关键词
cycloaddition; domino reactions; heterocycles; metathesis; ruthenium
资金
- Ministry of Education, Culture, Sports, Science, and Technology, Japan (MEXT)
- ACT-C from Japan Science and Technology Agency (JST)
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [15K14976, 26288051, 15KT0063, 15H04632] Funding Source: KAKEN
N-Alkyl-N-(2-vinylbenzyl) prop-2-en-1-amine derivatives undergo a one-pot olefin isomerization/aliphatic enamine ring-closing metathesis (RCM)/oxidation/1,3-dipolar cycloaddition sequence with the ruthenium complex, Ru(CO)HCl(PPh3)(3), a second generation Hoveyda-Grubbs catalyst, and a 1,3-dipolarophile. Overall, in a single operation the reaction sequence converts simple benzylamine derivatives into isoindolo[1,2-a]isoquinolines with a p-conjugated four-ring system, through three unique ruthenium-catalyzed transformations.
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