期刊
NEUROIMAGE
卷 127, 期 -, 页码 472-483出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2015.11.014
关键词
Ultrasound imaging; Blood flow; Microvascular imaging; Ultrafast Doppler; 3D rat brain; Tomography; Wiener filter
资金
- European Research Council under the European Union's Seventh Framework Programme (FP7)/ERC grant [339244-FUSIMAGINE]
- Agence Nationale de la Recherche under the program Future Investments
- Laboratory of Excellence [ANR-10-LABX-24 LABEX WIFI, ANR-10-IDEX-0001-02 PSL, ANR-10-IAIHU-06]
4D ultrasound microvascular imaging was demonstrated by applying ultrafast Doppler tomography (UFD-T) to the imaging of brain hemodynamics in rodents. In vivo real-time imaging of the rat brain was performed using ultrasonic plane wave transmissions at very high frame rates (18,000 frames per second). Such ultrafast frame rates allow for highly sensitive and wide-field-of-view 2D Doppler imaging of blood vessels far beyond conventional ultrasonography. Voxel anisotropy (100 mu m x 100 mu m x 500 mu m) was corrected for by using a tomographic approach, which consisted of ultrafast acquisitions repeated for different imaging plane orientations over multiple cardiac cycles. UFT-D allows for 4D dynamic microvascular imaging of deep-seated vasculature (up to 20 mm) with a very high 4D resolution (respectively 100 mu m x 100 mu m x 100 mu m and 10 ms) and high sensitivity to flow in small vessels (>1 mm/s) for a whole-brain imaging technique without requiring any contrast agent. 4D ultrasound microvascular imaging in vivo could become a valuable tool for the study of brain hemodynamics, such as cerebral flow autoregulation or vascular remodeling after ischemic stroke recovery, and, more generally, tumor vasculature response to therapeutic treatment. (C) 2015 Elsevier Inc. All rights reserved.
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