期刊
NEUROIMAGE
卷 128, 期 -, 页码 85-95出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2015.12.032
关键词
Brain tissue; White matter; Myelin; T-1 contrast; Magnetization transfer; Macromolecular content
资金
- Intramural program of NINDS
MRI based on T-1 relaxation contrast is increasingly being used to study brain morphology and myelination. Although it provides for excellent distinction between the major tissue types of gray matter, white matter, and CSF, reproducible quantification of T-1 relaxation rates is difficult due to the complexity of the contrast mechanism and dependence on experimental details. In this work, we perform simulations and inversion-recovery MRI measurements at 3 T and 7 T to show that substantial measurement variability results from unintended and uncontrolled perturbation of the magnetization of MRI-invisible H-1 protons of lipids and macromolecules. This results in bi-exponential relaxation, with a fast component whose relative contribution under practical conditions can reach 20%. This phenomenon can strongly affect apparent relaxation rates, affect contrast between tissue types, and result in contrast variations over the brain. Based on this novel understanding, ways are proposed to minimize this experimental variability and its effect on T-1 contrast, quantification accuracy and reproducibility. Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据