期刊
NEUROIMAGE
卷 142, 期 -, 页码 663-667出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2015.06.057
关键词
Dopamine; PET; Amphetamine; Stimulants; D-2/3; Striatum; PFC
资金
- Kootstra post-doctoral fellowship
- Network of European Neuroscience Schools (NENS)
- Limburg University Fund (SWOL)
- Medical Research Council (UK) [MR/K015192, MR/K022474]
- Eli Lilly (HHCC)
- Hofmann la Roche [BP29001]
- Takeda [ROF-SCHZ_106]
Experimental tasks and stimulant paradigms in combination with D-2/3 emission tomography have been essential in understanding the dopamine (DA) system. However, whereas task-induced DA release is dependent on a mechanism that is largely similar throughout the brain, the DA-increasing stimulant mechanism of action changes drastically from striatum to cortex. We posit the problems that may be encountered when translating the stimulant emission tomography paradigm from striatum to PFC. After comparing the available human data on task- and stimulant-induced changes in extracellular PFC DA assessed with PET, we hypothesize that the stimulant paradigm in the PFC, even with high affinity tracers, may not completely capture the true effect of stimulants on extracellular PFC DA levels. Task-induced and stimulant-induced effects on extracellular PFC DA measured with emission tomography should therefore be regarded as different phenomena. We conclude with future directions and alternative probes to measure PFC DA transmission with emission tomography. (C) 2015 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据