期刊
NEUROGASTROENTEROLOGY AND MOTILITY
卷 28, 期 11, 页码 1613-1618出版社
WILEY
DOI: 10.1111/nmo.12979
关键词
ion channels; irritable bowel syndrome; microbiome; serotonin; TRP; visceral hypersensitivity
资金
- NICHD NIH HHS [T32 HD057850, T32 HD007523] Funding Source: Medline
- NIDDK NIH HHS [R01 DK099611, R01 DK103872] Funding Source: Medline
Ion channels are expressed throughout the gastrointestinal system and regulate nearly every aspect of digestion, including fluid secretion and absorption, motility, and visceral sensitivity. It is therefore not surprising that in the setting of functional bowel disorders, such as irritable bowel syndrome (IBS), ion channels are often altered in terms of expression level and function and are a target of pharmacological intervention. This is particularly true of their role in driving abdominal pain through visceral hypersensitivity (VH), which is the main reason IBS patients seek medical care. In the study by Scanzi etal., in the current issue of this journal, they provide evidence that the T-type voltage-gated calcium channel (Ca-v) Ca(v)3.2 is upregulated in human IBS patients, and is necessary for the induction of an IBS-like disease state in mice. In this mini-review, we will discuss the contribution of specific ion channels to VH in IBS, both in human patients and rodent models. We will also discuss how Ca(v)3.2 may play a role as an integrator of multiple environmental stimuli contributing toward VH.
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