期刊
NEUROEPIDEMIOLOGY
卷 46, 期 3, 页码 157-165出版社
KARGER
DOI: 10.1159/000443706
关键词
Charcot-Marie-Tooth disease; Epidemiology; Prevalence; Public health
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/CNPq/Brazil
- Fundacao de Amparo a Pesquisa do Estado de Sergipe/FAPITEC-SE
Background: Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy. CMT is classified into 2 main subgroups: CMT type 1 (CMT1; demyelinating form) and CMT type 2 (CMT2; axonal form). The objectives of this study were to systematically review and assess the quality of studies reporting the incidence and/or prevalence of CMT worldwide. Summary: A total of 802 studies were initially identified, with only 12 meeting the inclusion criteria. CMT prevalence was reported in 10 studies and ranged from 9.7/100,000 in Serbia to 82.3/100,000 in Norway. The frequency of the main subtypes varied from 37.6 to 84% for CMT1 and from 12 to 35.9% for CMT2; the country with the lowest prevalence of CMT1 was Norway, and the country with the highest prevalence of CMT1 was Iceland; on the other hand, CMT2 was least prevalent in the United Kingdom and most prevalent in Norway. Key Messages: This review reveals the gaps that still exist in the epidemiological knowledge of CMT around the world. Published studies are of varying quality and utilise different methodologies, thus precluding a robust conclusion. Additional research focusing on epidemiological features of CMT in different nations and different ethnic groups is needed. (C) 2016 S. Karger AG, Basel
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