期刊
NEUROENDOCRINOLOGY
卷 104, 期 3, 页码 223-238出版社
KARGER
DOI: 10.1159/000445895
关键词
Kisspeptin; Amygdala; Olfactory bulb; Gonadotropic axis
资金
- MRC grant
- Newton International Fellowship programme [NF130516]
- Royal Society
- British Academy
- British Society for Neuroendocrinology
- BBSRC [BB/F019009/1, BB/J004723/1] Funding Source: UKRI
- Royal Society [NF130516] Funding Source: Royal Society
Kisspeptins and their receptors are potent regulators of the gonadotropic axis. Kisspeptin neurons are found mainly in the hypothalamic arcuate nucleus and the anteroventral periventricular nucleus. However, there is also a third population of kisspeptin neurons, located in the amygdala. We used fluorescence immunohistochemistry to quantify and localize the amygdala kisspeptin neurons and to reveal close apposition and putative innervations by vasopressinergic and tyrosine hydroxylase-positive dopaminergic neurons. Using microinjections of retro-and anterograde tracers, and viral transfection systems in rats and transgenic mice, we showed reciprocal connectivity between the accessory olfactory bulb and the amygdala kisspeptin neurons. In vitro recordings indicate an inhibitory action of kisspeptin on mitral cells in the accessory olfactory bulb. Using viral specific cell gene expression in transgenic mice in combination with double immunofluorescence histochemistry, we found that the amygdala kisspeptin neurons also project to gonadotropin-releasing hormone (GnRH) neurons in the preoptic area. Our neuroanatomical and electrophysiological data suggest that amygdala kisspeptin neurons integrate social behav-iour and odour information into GnRH neurons in the preoptic area to coordinate the gonadotropic axis and the appropriate output behaviour to odour cues. (C) 2016 S. Karger AG, Basel
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