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Review
Microbiology
Hannah E. Davis et al.
Summary: Long COVID is a common and debilitating illness that affects at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, with a wide range of symptoms and impacts on multiple organ systems. There are an estimated 65 million individuals worldwide with long COVID, and the number of cases is increasing daily. Current diagnostic and treatment options are insufficient, and there is a need for clinical trials to address leading hypotheses. Future research should account for biases and testing issues, build on viral-onset research, include marginalized populations, and meaningfully engage patients.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Benjamin A. Satterfield et al.
Summary: This article emphasizes the need to focus on cardiovascular sequelae in survivors of COVID-19 and calls for prospective studies to understand and mitigate these lasting consequences, with resources provided to monitor and study this population in the coming years.
NATURE REVIEWS CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ty J. Gluckman et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Benjamin Bowe et al.
Summary: A new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range of long COVID complications in individuals who have had SARS-CoV-2 compared to those with no reinfection.
Article
Biochemistry & Molecular Biology
Valentina O. Puntmann et al.
Summary: Cardiac symptoms are a common late complication of COVID-19 infection in previously healthy individuals. Ongoing inflammatory cardiac involvement may explain the persistence of these symptoms, and magnetic resonance imaging and measurement of cardiac injury biomarkers can assist in detecting this inflammation.
Article
Multidisciplinary Sciences
C. Kedor et al.
Summary: Some COVID-19 patients experience long-lasting symptoms, such as fatigue and exertion intolerance, even after recovery. These symptoms are similar to those seen in non-COVID-19 patients and may be related to low-level inflammation and hypoperfusion.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Marc K. Halushka et al.
Summary: The COVID-19 pandemic is associated with significant cardiovascular involvement, with common cardiovascular histopathological findings reported in autopsied hearts. However, the true prevalence of conditions such as myocarditis may be lower than initially thought. Further research is needed to clarify the exact impact of COVID-19 on cardiovascular health.
CARDIOVASCULAR PATHOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Saurabh Rajpal et al.
Article
Cardiac & Cardiovascular Systems
Dario Pellegrini et al.
Summary: Analysis of heart tissue from 40 deceased COVID-19 patients revealed that microthrombi were the most common pathological cause of myocyte necrosis. Female patients with chronic kidney disease and shorter symptom onset to admission time were more likely to have myocyte necrosis. Tailored antithrombotic strategies may be useful to counteract the cardiac effects of COVID-19 infection.
Article
Biochemistry & Molecular Biology
Carole H. Sudre et al.
Summary: Reports on long-lasting COVID-19 symptoms, known as 'long COVID', are increasing. Analysis of data from over 4,000 COVID-19 cases revealed that long COVID is more common in older individuals, those with higher body mass index, and females. Experiencing more than five symptoms in the first week of illness was associated with long COVID. A simple model showed promise in distinguishing between short and long COVID cases early in the disease.
Article
Cardiac & Cardiovascular Systems
Daniel Brito et al.
Summary: This study aimed to explore the spectrum of cardiac abnormalities in student athletes who returned to university campus in July 2020 with uncomplicated COVID-19. It was found that more than one in three previously healthy college athletes recovering from COVID-19 showed imaging features of resolving pericardial inflammation, with no specific imaging features of ongoing myocarditis identified. Further studies are needed to understand the clinical implications and long-term evolution of these abnormalities in uncomplicated COVID-19.
JACC-CARDIOVASCULAR IMAGING
(2021)
Editorial Material
Orthopedics
Simon Decary et al.
Summary: The term long COVID, coined by patients, describes the long-term consequences of COVID-19. Patients with long COVID are asking for rehabilitation, but exercise-based rehabilitation may have adverse effects, leading to concerns about both long COVID and ME.
JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Radu Tanacli et al.
Summary: Despite the ongoing global pandemic, the impact of COVID-19 on cardiac structure and function is still not completely understood. Myocarditis is a rare but potentially serious complication of other viral infections with variable recovery, and is, in some cases, associated with long-term cardiac remodeling and functional impairment. The study revealed that SARS-CoV-2 infection was associated with relatively mild but variable cardiac involvement, with more symptomatic COVID-19 patients and those with higher clinical care demands more likely to exhibit chronic inflammation and impaired cardiac function compared to patients with milder forms of the disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ziyad Al-Aly et al.
Summary: This study comprehensively describes the post-acute sequelae of COVID-19 using national healthcare databases, finding increased risk of death and use of health resources beyond the first 30 days of illness, as well as incident sequelae in various organ systems, increased use of therapeutic agents, and evidence of laboratory abnormalities. The findings show a risk gradient according to the severity of acute COVID-19 infection and highlight the burden of health loss experienced by patients who survive the acute phase.
Article
Cardiac & Cardiovascular Systems
Philipp de Leuw et al.
Summary: The study aimed to explore the relationship between cardiac imaging measures and cardiovascular outcomes in PLWH on HAART. The findings showed significant associations between diffuse myocardial fibrosis and LV remodeling with adverse cardiovascular events in PLWH, suggesting the potential for personalized screening and early intervention strategies to reduce the burden of HF in this population.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Biochemistry & Molecular Biology
Bjorn Blomberg et al.
Summary: An analysis of patients with SARS-CoV-2 infections in Bergen, Norway, revealed that a high proportion of patients experienced long-term COVID symptoms at 6 months, even though they were relatively young and had only mild to moderate acute COVID-19 symptoms. This highlights the significance of infection control measures, such as vaccination.
Review
Biochemistry & Molecular Biology
Anthony L. Komaroff et al.
Summary: SARS-CoV-2 infection can lead to chronic and acute diseases, with postacute sequelae including potential organ damage and symptoms, as well as a post-COVID19 syndrome called 'long COVID' resembling ME/CFS symptoms.
TRENDS IN MOLECULAR MEDICINE
(2021)
Article
Clinical Neurology
Angus Mackay
Summary: Some COVID-19 patients are experiencing prolonged Post-COVID-19 Fatigue Syndrome, similar to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), but the underlying pathophysiological explanation is still unclear. It is suggested that the hypothalamic paraventricular nucleus (PVN) may play a central role in the development of this syndrome, with SARS-CoV-2 acting as a severe stressor that could lead to ongoing dysfunction in genetically susceptible individuals. Further research is needed to explore the relationship between COVID-19 and ME/CFS, and brain-scanning studies may help to better understand the pathophysiology of Post-COVID-19 Fatigue Syndrome.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Daniel X. Augustine et al.
Summary: COVID-19 has been associated with cardiac complications in athletes, prompting international recommendations and consensus on returning to sports post-infection. This article examines the potential implications and management strategies.
EUROPEAN CARDIOLOGY REVIEW
(2021)
Article
Cardiac & Cardiovascular Systems
Eliecer Coto et al.
Summary: RAAS is crucial in COVID-19 pathogenesis, with lower levels of ACE2 increasing susceptibility to infection. Antihypertensive drugs targeting RAAS do not significantly affect disease outcome, while variations in RAAS genes may partly explain heterogeneous response to SARS-CoV-2 infection.
EUROPEAN CARDIOLOGY REVIEW
(2021)
Review
Cardiac & Cardiovascular Systems
Jonathan S. Gordon et al.
Summary: COVID-19 caused by SARS-CoV-2 has led to a global pandemic, with myocardial injury being a common occurrence in hospitalized patients. Biomarkers such as cardiac troponin and B-type natriuretic peptide are elevated in these patients and are correlated with illness severity and mortality. Cytokines like IL-6 are often elevated in patients with ACovCS, indicating a possible connection to the myocardial injury.
CURRENT HEART FAILURE REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Cristina Basso et al.
EUROPEAN HEART JOURNAL
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Peter Libby et al.
EUROPEAN HEART JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Juan R. Rey et al.
EUROPEAN JOURNAL OF HEART FAILURE
(2020)
Article
Cardiac & Cardiovascular Systems
Ole Hudowenz et al.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2020)
Article
Cardiac & Cardiovascular Systems
Rocco A. Montone et al.
EUROPEAN CARDIOLOGY REVIEW
(2020)
Article
Cardiac & Cardiovascular Systems
Antoni Martinez-Rubio et al.
EUROPEAN CARDIOLOGY REVIEW
(2020)
Article
Rheumatology
S. Mavrogeni et al.
Article
Rheumatology
Lea Winau et al.
ANNALS OF THE RHEUMATIC DISEASES
(2018)
Article
Rheumatology
Tatiana S. Rodriguez-Reyna et al.
Article
Cardiac & Cardiovascular Systems
Sabine Pankuweit et al.
HEART FAILURE REVIEWS
(2013)
Article
Cardiac & Cardiovascular Systems
Mariko L. Ishimori et al.
JACC-CARDIOVASCULAR IMAGING
(2011)
Article
Rheumatology
A-L Hachulla et al.
ANNALS OF THE RHEUMATIC DISEASES
(2009)
Article
Urology & Nephrology
GD Laverman et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2004)
