The impact of sedative and vasopressor agents on cerebrovascular reactivity in severe traumatic brain injury

Article Critical Care Medicine

Impact of Chronological Age and Biological Sex on Cerebrovascular Reactivity in Moderate/Severe Traumatic Brain Injury: A CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Study

Carleen Batson et al.

Summary: This study investigates the impact of age and biological sex on cerebral physiology and finds a positive linear correlation between PAx, RAC, and age, but no relationship between PRx and age.

JOURNAL OF NEUROTRAUMA (2023)

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Article Critical Care Medicine

Optimal bispectral index level of sedation and cerebral oximetry in traumatic brain injury: a non-invasive individualized approach in critical care?

Logan Froese et al.

Summary: This study suggests that COx_a is capable of detecting the relationship between depth of sedation and autoregulatory capacity, providing important guidance for individualized sedation in neuroprotection.

INTENSIVE CARE MEDICINE EXPERIMENTAL (2022)

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Article Anesthesiology

Evaluation of the relationship between slow-waves of intracranial pressure, mean arterial pressure and brain tissue oxygen in TBI: a CENTER-TBI exploratory analysis

Frederick A. Zeiler et al.

Summary: The study investigated the relationship between slow-wave fluctuations of intracranial pressure (ICP), mean arterial pressure (MAP) and brain tissue oxygen (PbtO(2)) over time in traumatic brain injury (TBI) patients. While ICP and MAP showed similar structures in time, PbtO(2) displayed a different optimal structure. PbtO(2) did not reliably respond to slow-wave fluctuations in MAP.

JOURNAL OF CLINICAL MONITORING AND COMPUTING (2021)

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Review Critical Care Medicine

The Limited Impact of Current Therapeutic Interventions on Cerebrovascular Reactivity in Traumatic Brain Injury: A Narrative Overview

Logan Froese et al.

Summary: The current ICU treatment strategies for TBI patients focus on ICP- and CPP-directed therapeutics, while impaired cerebrovascular reactivity is emerging as a significant factor in poor outcomes. Although emerging treatment paradigms target personalized CPP and ICP thresholds based on cerebrovascular reactivity, further research into the molecular pathways involved in impaired cerebrovascular reactivity is needed to develop preventive and therapeutic measures.

NEUROCRITICAL CARE (2021)

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Article Critical Care Medicine

Effects of Norepinephrine, Propofol, and Hemoglobin Concentration on Dynamic Measurements of Cerebrovascular Reactivity in Acute Brain Injury

Samuel P. Klein et al.

Summary: Effects of norepinephrine and propofol infusion rates and hemoglobin concentration on dynamic measurements of cerebrovascular reactivity in acute brain injured patients were found to be non-significant. Future trials on cerebrovascular reactivity-steered management and treatment of CA impairment may not need to consider these variables.

JOURNAL OF NEUROTRAUMA (2021)

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Article Physiology

Aquaporin 4 differentially modulates osmotic effects on vasopressin neurons in rat supraoptic nucleus

Xiaoran Wang et al.

Summary: The study demonstrates that the interaction between AQP4 and GFAP in the rat supraoptic nucleus can influence vasopressin neuronal activity through osmotic effects on astrocytes.

ACTA PHYSIOLOGICA (2021)

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Article Critical Care Medicine

Targeting Autoregulation-Guided Cerebral Perfusion Pressure after Traumatic Brain Injury (COGiTATE): A Feasibility Randomized Controlled Clinical Trial

Jeanette Tas et al.

Summary: This study evaluated the feasibility and safety of CA-guided CPP management in TBI patients requiring intracranial pressure monitoring and therapy. The results demonstrate that targeting an individual and dynamic CA-guided CPP is feasible and safe in TBI patients, encouraging further prospective trials powered for clinical outcomes.

JOURNAL OF NEUROTRAUMA (2021)

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Review Clinical Neurology

Continuous Time-Domain Cerebrovascular Reactivity Metrics and Discriminate Capacity for the Upper and Lower Limits of Autoregulation: A Scoping Review of the Animal Literature

Amanjyot Singh Sainbhi et al.

Summary: Cerebral blood flow is regulated by cerebral vessels within a range of systemic arterial pressures through a process known as cerebral autoregulation. Traumatic brain injury can impair this autoregulation, leading to changes in the autoregulatory curve. Surrogate metrics, such as cerebrovascular reactivity (CVR) metrics, have been increasingly used in bedside TBI care to assess individualized cerebral perfusion pressure targets. While some metrics show the ability to discriminate the lower limit of autoregulation, further research is needed to evaluate their validity against the upper limit.

NEUROTRAUMA REPORTS (2021)

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Article Clinical Neurology

Impact of Age and Biological Sex on Cerebrovascular Reactivity in Adult Moderate/Severe Traumatic Brain Injury: An Exploratory Analysis

Carleen Batson et al.

Summary: Age and biological sex can impact cerebrovascular reactivity post-TBI, with age showing a positive linear relationship with certain cerebrovascular function measures. In this study, biological sex did not have a significant impact on cerebrovascular reactivity indices. Further research is needed to validate these findings and explore the utility of different cerebrovascular reactivity indices, with PAx and RAC potentially being better metrics for detecting impaired cerebrovascular reactivity in elderly patients.

NEUROTRAUMA REPORTS (2021)

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Article Anesthesiology

Comparison of high versus low frequency cerebral physiology for cerebrovascular reactivity assessment in traumatic brain injury: a multi-center pilot study

Eric P. Thelin et al.

JOURNAL OF CLINICAL MONITORING AND COMPUTING (2020)

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Article Critical Care Medicine

Association between Cerebrovascular Reactivity Monitoring and Mortality Is Preserved When Adjusting for Baseline Admission Characteristics in Adult Traumatic Brain Injury: A CENTER-TBI Study

Frederick A. Zeiler et al.

JOURNAL OF NEUROTRAUMA (2020)

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Article Critical Care Medicine

A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC)

Randall Chesnut et al.

INTENSIVE CARE MEDICINE (2020)

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Article Critical Care Medicine

Improving Prediction of Favourable Outcome After 6 Months in Patients with Severe Traumatic Brain Injury Using Physiological Cerebral Parameters in a Multivariable Logistic Regression Model

Frank C. Bennis et al.

NEUROCRITICAL CARE (2020)

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Editorial Material Clinical Neurology

The CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Research Collaborative

Francis Bernard et al.

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES (2020)

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Article Critical Care Medicine

Brain Tissue Oxygen and Cerebrovascular Reactivity in Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Exploratory Analysis of Insult Burden

Frederick A. Zeiler et al.

JOURNAL OF NEUROTRAUMA (2020)

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Article Clinical Neurology

The impact of hypertonic saline on cerebrovascular reactivity and compensatory reserve in traumatic brain injury: an exploratory analysis

Logan Froese et al.

ACTA NEUROCHIRURGICA (2020)

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Article Clinical Neurology

The Impact of Vasopressor and Sedative Agents on Cerebrovascular Reactivity and Compensatory Reserve in Traumatic Brain Injury: An Exploratory Analysis

Logan Froese et al.

NEUROTRAUMA REPORTS (2020)

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Article Clinical Neurology

Twenty-Five Years of Intracranial Pressure Monitoring After Severe Traumatic Brain Injury: A Retrospective, Single-Center Analysis

Joseph Donnelly et al.

NEUROSURGERY (2019)

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Article Clinical Neurology

Cerebrovascular reactivity is not associated with therapeutic intensity in adult traumatic brain injury: a CENTER-TBI analysis

Frederick A. Zeiler et al.

ACTA NEUROCHIRURGICA (2019)

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Article Critical Care Medicine

A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC)

Gregory W. J. Hawryluk et al.

INTENSIVE CARE MEDICINE (2019)

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Article Critical Care Medicine

Critical Thresholds of Intracranial Pressure-Derived Continuous Cerebrovascular Reactivity Indices for Outcome Prediction in Noncraniectomized Patients with Traumatic Brain Injury

Frederick A. Zeiler et al.

JOURNAL OF NEUROTRAUMA (2018)

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Article Critical Care Medicine

Validation of Intracranial Pressure-Derived Cerebrovascular Reactivity Indices against the Lower Limit of Autoregulation, Part II: Experimental Model of Arterial Hypotension

Frederick A. Zeiler et al.

JOURNAL OF NEUROTRAUMA (2018)

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Article Critical Care Medicine

Validation of Pressure Reactivity and Pulse Amplitude Indices against the Lower Limit of Autoregulation: Part I: Experimental Intracranial Hypertension

Frederick A. Zeiler et al.

JOURNAL OF NEUROTRAUMA (2018)

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Article Clinical Neurology

Impaired cerebral compensatory reserve is associated with admission imaging characteristics of diffuse insult in traumatic brain injury

Frederick A. Zeiler et al.

ACTA NEUROCHIRURGICA (2018)

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Article Clinical Neurology

Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition

Nancy Carney et al.

NEUROSURGERY (2017)

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Article Oncology

Advances in Precision Medicine: Tailoring Individualized Therapies

Kyle B. Matchett et al.

CANCERS (2017)

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Article Critical Care Medicine

Individualizing Thresholds of Cerebral Perfusion Pressure Using Estimated Limits of Autoregulation

Joseph Donnelly et al.

CRITICAL CARE MEDICINE (2017)

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Review Anesthesiology

The Cerebrovascular Response to Ketamine: A Systematic Review of the Animal and Human Literature

Frederick A. Zeiler et al.

JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY (2016)

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Review Critical Care Medicine

Optimizing sedation in patients with acute brain injury

Mauro Oddo et al.

CRITICAL CARE (2016)

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Proceedings Paper Clinical Neurology

Can Optimal Cerebral Perfusion Pressure in Patients with Severe Traumatic Brain Injury Be Calculated Based on Minute-by-Minute Data Monitoring?

Bart Depreitere et al.

INTRACRANIAL PRESSURE AND BRAIN MONITORING XV (2016)

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Article Critical Care Medicine

Utility of neuron-specific enolase in traumatic brain injury; relations to S100B levels, outcome, and extracranial injury severity

Eric Peter Thelin et al.

CRITICAL CARE (2016)

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Article Critical Care Medicine

Clinical and Physiological Events That Contribute to the Success Rate of Finding Optimal Cerebral Perfusion Pressure in Severe Brain Trauma Patients

Corien S. A. Weersink et al.

CRITICAL CARE MEDICINE (2015)

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Article Clinical Neurology

Short pressure reactivity index versus long pressure reactivity index in the management of traumatic brain injury

Erhard W. Lang et al.

JOURNAL OF NEUROSURGERY (2015)

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Article Clinical Neurology

Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): A Prospective Longitudinal Observational Study

Andrew I. R. Maas et al.

NEUROSURGERY (2015)

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Article Clinical Neurology

Pressure autoregulation monitoring and cerebral perfusion pressure target recommendation in patients with severe traumatic brain injury based on minute-by-minute monitoring data Clinical article

Bart Depreitere et al.

JOURNAL OF NEUROSURGERY (2014)

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Article Critical Care Medicine

Post-Traumatic Multimodal Brain Monitoring: Response to Hypertonic Saline

Celeste Dias et al.

JOURNAL OF NEUROTRAUMA (2014)

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Article Transplantation

Long-term vasopressin-V2-receptor stimulation induces regulation of aquaporin 4 protein in renal inner medulla and cortex of Brattleboro rats

Soren Brandt Poulsen et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2013)

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Article Critical Care Medicine

Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury

Marcel J. H. Aries et al.

CRITICAL CARE MEDICINE (2012)

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Article Critical Care Medicine

Cerebral Microdialysis Effects of Propofol versus Midazolam in Severe Traumatic Brain Injury

Michele Tanguy et al.

JOURNAL OF NEUROTRAUMA (2012)

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Article Critical Care Medicine

Critical Thresholds for Cerebrovascular Reactivity After Traumatic Brain Injury

E. Sorrentino et al.

NEUROCRITICAL CARE (2012)

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Article Clinical Neurology

The Relationship Between Cerebral Blood Flow Autoregulation and Cerebrovascular Pressure Reactivity After Traumatic Brain Injury

Karol P. Budohoski et al.

NEUROSURGERY (2012)

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Article Anesthesiology

A pilot study of cerebral and haemodynamic physiological changes during sedation with dexmedetomidine or propofol in patients with acute brain injury

M. L. James et al.

ANAESTHESIA AND INTENSIVE CARE (2012)

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Article Clinical Neurology

Low-frequency sampling for PRx calculation does not reduce prognostication and produces similar CPPopt in intracerebral haemorrhage patients

Edgar Santos et al.

ACTA NEUROCHIRURGICA (2011)

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Article Anesthesiology

The Lund Concept for the Treatment of Patients With Severe Traumatic Brain Injury

Per-Olof Grande

JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY (2011)

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Article Physiology

Vasopressin-induced differential stimulation of AQP4 splice variants regulates the in-membrane assembly of orthogonal arrays

Alfred N. Van Hoek et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2009)

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Review Critical Care Medicine

Physiological and biochemical principles underlying volume-targeted therapy - The Lund concept

CH Nordstrom

NEUROCRITICAL CARE (2005)

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Article Anesthesiology

Effects of propofol on cerebral oxygenation and metabolism after head injury

AJ Johnston et al.

BRITISH JOURNAL OF ANAESTHESIA (2003)

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Article Anesthesiology

The effects of large-dose propofol on cerebrovascular pressure autoregulation in head-injured patients

LA Steiner et al.

ANESTHESIA AND ANALGESIA (2003)

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Article Clinical Neurology

Carbon dioxide reactivity, pressure autoregulation, and metabolic suppression reactivity after head injury: a transcranial Doppler study

JH Lee et al.

JOURNAL OF NEUROSURGERY (2001)

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Article Neurosciences

A novel role of vasopressin in the brain: Modulation of activity-dependent water flux in the neocortex

H Niermann et al.

JOURNAL OF NEUROSCIENCE (2001)

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The impact of sedative and vasopressor agents on cerebrovascular reactivity in severe traumatic brain injury

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