期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 357, 期 14-15, 页码 3171-3186出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500495
关键词
alanates; Grignard reagents; N-heterocylic carbene (NHC) ligands; transition metal-free conditions
资金
- Swiss National Research Foundation [200020-126663]
- Swiss National Science Foundation (SNF) [200020_126663] Funding Source: Swiss National Science Foundation (SNF)
Two new N-heterocyclic carbene (NHC) ligands have been synthesized and employed in the transition metal-free asymmetric allylic alkylation (AAA) mediated by Grignard reagents and magnesium alanates. The employment of these ligands showed high yields and improved regio- and enantio-selectivity in the formation of tertiary and quaternary stereocenters. Moreover, the low catalyst loading (up to 0.3 mol%) and high scalability (up to 10 mmol) of this improved methodology provide a convenient access to biologically active compounds and synthetically valuable intermediates.
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