期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 134, 期 -, 页码 135-144出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2015.12.004
关键词
Memory; Medial temporal lobe; Hippocampus; Eye movements; Saccades; Neurons; Free-viewing; Primate
资金
- National Institute of Mental Health [MH080007, MH093807]
- National Institutes of Health [ORIP-0D010425]
Investigations into the neural basis of memory in human and non-human primates have focused on the hippocampus and associated medial temporal lobe (MTL) structures. However, how memory signals from the hippocampus affect motor actions is unknown. We propose that approaching this question through eye movement, especially by assessing the changes in looking behavior that occur with experience, is a promising method for exposing neural computations within the hippocampus. Here, we review how looking behavior is guided by memory in several ways, some of which have been shown to depend on the hippocampus, and how hippocampal neural signals are modulated by eye movements. Taken together, these findings highlight the need for future research on how MTL structures interact with the oculomotor system. Probing how the hippocampus reflects and impacts motor output during looking behavior renders a practical path to advance our understanding of the hippocampal memory system. (C) 2016 Elsevier Inc. All rights reserved.
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