期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 134, 期 -, 页码 65-77出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2015.11.018
关键词
Hippocampus; Reward; Dopamine; Pattern-separation; Memory; Context
资金
- Wellcome Trust Senior Investigator Award [098362/Z/12/Z]
- UCL Grand challenges studentship in Biomedicine
- German Research Council [SFB 776, TP A7]
- Wellcome Trust [091593/Z/10/Z]
Animal studies indicate that hippocampal representations of environmental context modulate reward related processing in the substantia nigra and ventral tegmental area (SN/VTA), a major origin of dopamine in the brain. Using functional magnetic resonance imaging (fMRI) in humans, we investigated the neural specificity of context-reward associations under conditions where the presence of perceptually similar neutral contexts imposed high demands on a putative hippocampal function, pattern separation. The design also allowed us to investigate how contextual reward enhances long-term memory for embedded neutral objects. SN/VTA activity underpinned specific context-reward associations in the face of perceptual similarity. A reward-related enhancement of long-term memory was restricted to the condition where the rewarding and the neutral contexts were perceptually similar, and in turn was linked to co-activation of the hippocampus (subfield DG/CA3) and SN/VTA. Thus, an ability of contextual reward to enhance memory for focal objects is closely linked to context-related engagement of hippocampal-SN/VTA circuitry. (C) 2015 The Authors. Published by Elsevier Inc.
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