期刊
NEUROBIOLOGY OF AGING
卷 48, 期 -, 页码 34-47出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2016.08.005
关键词
MtDNA damage; Ketogenic diet; Biogenesis; Neurodegeneration
资金
- Research Council of Norway
- Norwegian Health Association
- Lundbeck Foundation (Denmark)
- South-Eastern Norway Regional Health Authority
- Lundbeck Foundation [R170-2014-1028, R194-2015-948] Funding Source: researchfish
Mitochondrial genome maintenance plays a central role in preserving brain health. We previously demonstrated accumulation of mitochondrial DNA damage and severe neurodegeneration in transgenic mice inducibly expressing a mutated mitochondrial DNA repair enzyme (mutUNG1) selectively in forebrain neurons. Here, we examine whether severe neurodegeneration in mutUNG1-expressing mice could be rescued by feeding the mice a ketogenic diet, which is known to have beneficial effects in several neurological disorders. The diet increased the levels of superoxide dismutase 2, and mitochondrial mass, enzymes, and regulators such as SIRT1 and FIS1, and appeared to downregulate N-methyl-Daspartic acid (NMDA) receptor subunits NR2A/B and upregulate gamma-aminobutyric acid A (GABA(A)) receptor subunits alpha(1). However, unexpectedly, the ketogenic diet aggravated neurodegeneration and mitochondrial deterioration. Electron microscopy showed structurally impaired mitochondria accumulating in neuronal perikarya. We propose that aggravation is caused by increased mitochondrial biogenesis of generally dysfunctional mitochondria. This study thereby questions the dogma that a ketogenic diet is unambiguously beneficial in mitochondrial disorders. (C) 2016 Elsevier Inc. All rights reserved.
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