期刊
NEUROBIOLOGY OF AGING
卷 40, 期 -, 页码 68-77出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2015.12.023
关键词
Alzheimer's disease; Polygenic risk score; APOE; TREM2; Hippocampus; Amygdala
资金
- Australian National Health and Medical Research Council (NHMRC) [350833, 568969]
- NHMRC/Australian Research Council Strategic Award [401162]
- NHMRC [1045325, 310667, 401184, 568940]
- Commonwealth Scientific and Industrial Research Organisation Flagship Collaboration Fund Grant
- National Institute of Child Health and Human Development [R01 HD050735]
- National Health and Medical Research Council, Australia [NHMRC 486682, 1009064]
- European Union [FP6-2004-LIFESCIHEALTH-5]
- Alzheimer's Research Trust UK
- John and Lucille van Geest Foundation
- NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at the South London
- Maudsley NHS Foundation Trust
- Kings College London
- Guy's and St Thomas' Charity
- Maudsley Charity
- Academy of Finland, Kuopio University Hospital
- UEF-BRAIN
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]
- DOD ADNI (Department of Defense) [W81XWH-12-2-0012]
- National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering
- Canadian Institutes of Health Research
- Northern California Institute for Research and Education
- French National Foundation on Alzheimer's disease and related disorders
- LABEX (laboratory of excellence program investment for the future) DISTALZ grant
- Inserm
- Institut Pasteur de Lille
- Universite de Lille 2
- Lille University Hospital
- Medical Research Council [503480]
- Alzheimer's Research UK [503176]
- Wellcome Trust [082604/2/07/Z]
- German Federal Ministry of Education and Research (BMBF): Competence Network Dementia (CND) [01GI0102, 01GI0711, 01GI0420]
- NIH/NIA [R01 AG033193, U01 AG032984, U24 AG021886, U01 AG016976]
- NIA [AG081220]
- AGES [N01-AG-12100]
- NHLBI [R01 HL105756]
- Icelandic Heart Association
- Erasmus Medical Centre
- Erasmus University
- Alzheimer's Association [ADGC-10-196728]
- Perpetual Foundation Wilson Fellowship
- 7FP grant [601055 VPH-DARE@IT]
- Alzheimer's Australia Dementia Research Foundation Postdoctoral Fellowship
- NIH Big Data Center of Excellence [U54 EB020403]
- NIH
- NIBIB
- NCI
- Alzheimer's Society [167] Funding Source: researchfish
Reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer's disease (AD). Whether genetic risk factors for AD exert an effect on these subcortical structures independent of clinical status has not been fully investigated. We examine whether increased genetic risk for AD influences hippocampal and amygdala volumes in case-control and population cohorts at different ages, in 1674 older (aged >53 years; 17% AD, 39% mild cognitive impairment [MCI]) and 467 young (16-30 years) adults. An AD polygenic risk score combining common risk variants excluding apolipoprotein E (APOE), and a single nucleotide polymorphism in TREM2, were both associated with reduced hippocampal volume in healthy older adults and those with MCI. APOE epsilon 4 was associated with hippocampal and amygdala volume in those with AD and MCI but was not associated in healthy older adults. No associations were found in young adults. Genetic risk for AD affects the hippocampus before the clinical symptoms of AD, reflecting a neurodegenerative effect before clinical manifestations in older adults. (C) 2016 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据