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Article
Cardiac & Cardiovascular Systems
Janice Y. Chyou et al.
Summary: Acute atrial fibrillation refers to the detection of atrial fibrillation in the context of acute care or acute illness. It is associated with a high risk of long-term atrial fibrillation recurrence and requires clinical attention during acute hospitalization and long-term follow-up. Acute management involves a multipronged approach, including the identification and treatment of triggers, rate/rhythm control, and management of anticoagulation.
Review
Cardiac & Cardiovascular Systems
Syed Bukhari et al.
Summary: Cardiac amyloidosis (CA) is characterized by the deposition of amyloid fibrils derived from misfolding of transthyretin (ATTR) or light-chain (AL) proteins in the myocardium, leading to atrial fibrillation and thromboembolism. It also increases the risk of bleeding. This review explores the prevalence, pathophysiological mechanisms, bleeding risk, and anticoagulation strategies in CA, aiming to identify knowledge gaps for future research on thromboembolism in CA.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Pharmacology & Pharmacy
Francesco Ferrara et al.
Summary: Long COVID is a syndrome characterized by symptoms such as shortness of breath, fatigue, and cognitive dysfunction, which have a significant impact on daily life. It occurs in patients with a history of SARS-CoV-2 infection for at least 2 months and cannot be explained by alternative diagnoses after 3 months. The cause of Long COVID is believed to be related to deposits of tau protein.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Health Policy & Services
Francesco Ferrara et al.
Summary: The relaxed prescription regulations have led to an increase in prescribing and dispensing of new drugs for type 2 diabetes mellitus. This is in line with post-Covid-19 European policies, bringing therapies closer to the patient. However, it has also resulted in unpredictable healthcare spending. In Italy, the introduction of the National Plan for Reconstruction and Resilience aimed to give more prescribing freedom to General Practitioners, allowing them to directly prescribe certain categories of medicines for type 2 diabetes mellitus.
INTERNATIONAL JOURNAL OF HEALTHCARE MANAGEMENT
(2023)
Article
F. Ferrara et al.
Ethics, Medicine and Public Health
(2023)
Article
Cardiac & Cardiovascular Systems
Jose Miguel Calderon et al.
Summary: The study found that in the real world, the use of anticoagulant treatments differs significantly from guideline recommendations and shows variability in their use. NOACs offer better protection compared to other treatment groups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Steven Deitelzweig et al.
Summary: This study compared the real-world effectiveness and safety of non-vitamin K antagonist oral anticoagulants and vitamin K antagonists in patients with non-valvular atrial fibrillation. Through a systematic review and analysis of 55 studies, it was found that apixaban, dabigatran, and rivaroxaban were associated with a reduced risk of stroke or systemic embolism, ischemic stroke, intracranial hemorrhage, and all-cause mortality compared to vitamin K antagonists. Apixaban, dabigatran, and edoxaban, but not rivaroxaban, were also associated with a reduced risk of major bleeding. This study confirmed the real-world effectiveness and safety of non-vitamin K antagonist oral anticoagulants for the treatment of non-valvular atrial fibrillation, consistent with clinical trial evidence.
Article
Cardiac & Cardiovascular Systems
Zachary A. Sporn et al.
Review
Gastroenterology & Hepatology
Eleni Karapedi et al.
Summary: Atrial fibrillation (AF) is a common comorbidity in patients with liver cirrhosis, affecting their quality of life and prognosis. The decision about anticoagulation therapy is challenging due to the increased risk of both thrombosis and bleeding in cirrhosis patients. This review investigates the clinical literature regarding the use of direct-acting oral anticoagulants (DOACs) and traditional antithrombotic agents in patients with liver cirrhosis and AF.
ANNALS OF GASTROENTEROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
David Hutto et al.
Summary: This study evaluated the effectiveness and safety of direct oral anticoagulants (DOAC) in real-world settings and found that these studies often have short follow-up durations. All DOACs showed significant advantages in reducing the risk of stroke/systematic embolism (SE), but only dabigatran and apixaban showed lower risks of major bleeding compared to warfarin. The duration of follow-up was significantly correlated with the reduction of major bleeding for specific DOACs compared to warfarin.
IJC HEART & VASCULATURE
(2022)
Letter
Pharmacology & Pharmacy
Francesco Ferrara et al.
INDIAN JOURNAL OF PHARMACOLOGY
(2020)
