期刊
NEUROBIOLOGY OF AGING
卷 42, 期 -, 页码 91-100出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2016.02.032
关键词
Apolipoprotein E; Clusterin; Pulse pressure; Executive function; Victoria Longitudinal Study
资金
- National Institutes of Health (National Institute on Aging) [R01 AG008235]
- Canada Research Chairs program
- Alberta Health Services
- University Hospital Foundation
We examined independent and cumulative effects of 2 Alzheimer's-related genetic polymorphisms, Apolipoprotein E (APOE) and Clusterin (CLU), in relation to the deleterious effects of poor vascular health (pulse pressure [PP]) on executive function (EF) performance and change in nondemented older adults. Using a sample (n = 593; age range = 53-95 years) from the Victoria Longitudinal Study, we applied latent growth modeling to test the effect of PP, as moderated by APOE and CLU, on an EF latent variable. EF was affected by higher levels of PP but differentially less so for carriers of low-risk alleles (APOE epsilon 2+; CLU TT) than for moderate-or high-risk alleles (APOE epsilon 2+; CLU C+). The cumulative genetic risk of APOE plus CLU provided similar moderation of PP level effects on EF. Future research may focus on how APOE and CLU might provide different but complementary contributions to predicting EF level and change. Vascular health risk in synergistic association with risk-related polymorphisms can elucidate the neurobiological underpinnings of cognitive trajectories in nondemented aging. (C) 2016 Elsevier Inc. All rights reserved.
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