Recovery of suspended reimbursements of high-cost drugs subjected to monitoring registries and negotiated agreements (MEAs): a tool for governance and clinical appropriateness in the Italian reality

Article Pharmacology & Pharmacy

Long COVID could become a widespread post-pandemic disease? A debate on the organs most affected

Francesco Ferrara et al.

Summary: Long COVID is a syndrome characterized by symptoms such as shortness of breath, fatigue, and cognitive dysfunction, which have a significant impact on daily life. It occurs in patients with a history of SARS-CoV-2 infection for at least 2 months and cannot be explained by alternative diagnoses after 3 months. The cause of Long COVID is believed to be related to deposits of tau protein.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2023)

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Article Health Care Sciences & Services

Healthcare Systems across Europe and the US: The Managed Entry Agreements Experience

Michele Ciulla et al.

Summary: This systematic study analyzes the differences between the European and American healthcare systems in terms of pharmaceutical market approach. It emphasizes the use of managed entry agreements (MEAs) in European countries, as opposed to the unregulated pharmaceutical prices in the American market. Data were collected from various sources, and a literature review was conducted to gather information from the past ten years. The comparison reveals the importance of market access regulation in reducing therapy costs and improving the efficiency, quality, and accessibility for patients.

HEALTHCARE (2023)

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Article Pharmacology & Pharmacy

COVID-19 mRNA Vaccines: A Retrospective Observational Pharmacovigilance Study

Francesco Ferrara et al.

Summary: This retrospective pharmacovigilance study demonstrates that COVID-19 mRNA vaccines are safe in all population groups.

CLINICAL DRUG INVESTIGATION (2022)

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Article Cardiac & Cardiovascular Systems

Scientific Hypothesis for Treatment of COVID-19′s Lung Lesions by Adjusting ACE/ACE2 Imbalance

F. Ferrara et al.

Summary: The global COVID-19 pandemic, caused by the new Coronavirus SARS-CoV-2, has led to millions of deaths worldwide. The ACE-2 protein plays a crucial role in the infection process, making it a potential target for pharmacological intervention in treating COVID-19. Understanding the interactions between RAS, ACE-2, and ACE/ACE2 balance could provide valuable insights for developing effective treatments for the virus.

CARDIOVASCULAR TOXICOLOGY (2021)

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Article

Medicines shortages and the perception of healthcare professionals working in hospitals: An Italian case study

Andrea Zovi et al.

Journal of Interprofessional Education and Practice (2021)

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Article Pharmacology & Pharmacy

Logistics management provides greater efficiency, governance and compliance

Francesco Ferrara et al.

Summary: Direct dispensing (DD) has many advantages over dispensing on commission (DPC), including greater therapeutic appropriateness and cost savings. However, a complex warehouse organization is a major challenge for DD. With the increase in chronic patients and advanced therapies, direct care requires a new structure and logistics system.

INTERNATIONAL JOURNAL OF CLINICAL PHARMACY (2021)

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Article Pharmacology & Pharmacy

The Evolution of AIFA Registries to Support Managed Entry Agreements for Orphan Medicinal Products in Italy

Entela Xoxi et al.

Summary: Italy has a well-established system of national registries to support managed entry agreements and monitor innovative medicinal products with clinical and economic uncertainties, ensuring appropriate use and best value for money. The technological architecture of the registries is funded by pharmaceutical companies but governed by the national medicines agency.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Economics