期刊
CLINICAL OPHTHALMOLOGY
卷 17, 期 -, 页码 2413-2422出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OPTH.S415654
关键词
glaucoma; myopia; trabeculectomy; glaucoma progression
This study aimed to evaluate the effect of trabeculectomy on visual field progression in eyes with glaucoma and high myopia. The results showed that trabeculectomy reduced intraocular pressure and slowed down visual field deterioration, but the effect was weaker and nonsignificant in the highly myopic group.
Purpose: To evaluate the effect of trabeculectomy (Trab MMC) on visual field (VF) progression in eyes with glaucoma and high myopia.Patients and Methods: Patients diagnosed with primary open-angle glaucoma or exfoliation glaucoma who underwent Trab MMC as the first glaucoma surgery along with >3 VF tests preoperatively and postoperatively were enrolled. High myopia was defined as an axial length >26.5 mm. Postoperative reductions in intraocular pressure (IOP) were assessed by survival analysis using IOP measurements obtained preoperatively. The longitudinal trends of the outcome measures were evaluated using linear mixed models.Results: Thirty-five eyes of 32 patients were included in this study, including 22 eyes of 20 patients in non-highly myopic group and 13 eyes of 12 patients in highly myopic group. IOP decreased after Trab MMC, and the survival rate did not differ significantly in relation to axial length. Linear mixed-model analyses suggested that the inhibitory effects of Trab MMC on the rate of mean deviation (MD) changes were significant in the non-highly myopic group (-0.53 & PLUSMN; 0.15 dB/year preoperatively to -0.16 & PLUSMN; 0.13 dB/year postoperatively; P = 0.004), but not in the highly myopic group (-0.66 & PLUSMN; 0.19 dB/year preoperatively to -0.48 & PLUSMN; 0.18 dB/year postoperatively; P = 0.32).Conclusion: Trab MMC reduced IOP in both highly myopic and non-highly myopic eyes, and IOP reduction was very similar in both groups. The VF deterioration rate decreased in both groups, but the change was weaker and nonsignificant in the highly myopic group.
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