期刊
HELIYON
卷 9, 期 9, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.heliyon.2023.e19802
关键词
Bladder cancer; Cancer-associated fibroblasts; Proliferation; Invasion and metastasis; Chemotherapy resistance
This review provides an overview of the origin and function of cancer-associated fibroblasts (CAFs) in bladder cancer (BCa), highlighting their crucial role in cancer cell proliferation, invasion, metastasis, and chemotherapy resistance. It also offers further insights into their potential clinical applications.
Cancer-associated fibroblasts (CAFs) are key stromal cells in the tumor microenvironment (TME) that critically contribute to cancer initiation and progression. In bladder cancer (BCa), there is emerging evidence that BCa CAFs are actively involved in cancer cell proliferation, invasion, metastasis, and chemotherapy resistance. This review outlines the present knowledge of BCa CAFs, with a particular emphasis on their origin and function in BCa progression, and provides further insights into their clinical application.
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