4.5 Article

Accelerometer-measured physical activity patterns are associated with phenotypic age: Isotemporal substitution effects

期刊

HELIYON
卷 9, 期 9, 页码 -

出版社

CELL PRESS
DOI: 10.1016/j.heliyon.2023.e19158

关键词

Physical exercise; Sedentary behavior; Phenotypic age; Isotemporal substitution model; Cross-sectional study

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Prolonged sitting accelerates aging, while optimal physical activity patterns delay the process. This study investigated the association between sensor-based physical activity and phenotypic age using a nationwide population from the NHANES in the US. The results showed that prolonged sitting was positively associated with phenotypic age, while increasing LPA and MVPA was associated with younger phenotypic age. Substituting sedentary behavior with LPA or MVPA was found to reduce phenotypic age.
Prolonged sitting appears to accelerate aging, while optimal physical activity patterns have been found to delay the process. It is an emerging topic, and no conclusions have been reached regarding the relationship between physical activity patterns and biomarkers-measured aging. Hence, the aim of this study was to investigate the association between sensor-based objectively measured physical activity and phenotypic age using a nationwide population from the National Health and Nutrition Examination Survey (NHANES) in the United States. Weighted linear regression models were performed to evaluate the association between sedentary behavior, light intensity physical activity (LPA), moderate-to-vigorous physical activity (MVPA) and phenotypic age. A total of 6439 eligible participants were included and the weighted respondents were 49,964,300. Results showed that prolonged sitting was positively associated with phenotypic age in the fully adjusted model [beta (95% CI): 0.009(0.007,0.011), p < 0.001], while increasing volume of LPA and MVPA was associated with younger phenotypic age using the fully adjusted model [beta (95% CI):-0.010(-0.013,-0.006), p < 0.001;-0.062(-0.075,-0.048), p < 0.001]. By utilizing the Isotemporal Substitution Model, it was found that replacing 30 min of sedentary behavior with 30 min of LPA or MVPA per day was associated with estimated 0.4 or 1.9 years of phenotypic age reduction. According to the study's findings, maintaining a certain level of physical activity could delay the process of aging and intensity matters.

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