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Bibliometric analysis of global research on the role of apolipoprotein E in Alzheimer's disease

HELIYON (2023)

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Article Clinical Neurology

Does the imbalance in the apolipoprotein E isoforms underlie the pathophysiological process of sporadic Alzheimer's disease?

Madia Lozupone et al.

Summary: This article discusses the role of human apolipoprotein E (apoE) in the pathophysiology of Alzheimer's disease (AD), describing its impact on brain homeostasis, neuroinflammation, blood-brain barrier permeability, glial function, synaptogenesis, oral/gut microbiota, neural networks, amyloid beta deposition, and tau-mediated neurodegeneration. It also provides updates on different therapeutic approaches targeting apoE in AD treatment.

ALZHEIMERS & DEMENTIA (2023)

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Article Clinical Neurology

Whole genome sequencing-based copy number variations reveal novel pathways and targets in Alzheimer's disease

Chen Ming et al.

Summary: This study identified 3,012 rare AD-specific CNVs from whole genome sequencing data, with genes enriched in cellular glucuronidation and neuron projection pathways. Further investigation revealed that genes whose mRNA expressions are significantly correlated with common CNVs are involved in major histocompatibility complex class II receptor activity. Integration of CNVs, gene expression, and clinical and pathological traits highlighted a key CNV potentially regulating immune response in AD.

ALZHEIMERS & DEMENTIA (2022)

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Review Neurosciences

The probabilistic model of Alzheimer disease: the amyloid hypothesis revised

Giovanni B. Frisoni et al.

Summary: The amyloid hypothesis has long been the leading model for the pathogenesis of Alzheimer's disease, but a probabilistic model is proposed as an alternative due to the increasing understanding of the complex biology of Alzheimer's disease. This new model suggests that genetic factors, environmental exposures, and lower-risk genes play significant roles in different types of Alzheimer's disease, leading to a better understanding of disease pathophysiology and potentially accelerating the development of prevention and treatment strategies.

NATURE REVIEWS NEUROSCIENCE (2022)

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Article Psychiatry

A bibliometric analysis of 10 years of research on symptom networks in psychopathology and mental health

Ausin Berta et al.

Summary: This article analyzes the research literature on network analysis in psychopathology and mental health over the past decade. The study finds an increase in publications in this field, with a focus on symptom networks in depression, anxiety, and post-traumatic stress disorders. However, there are gaps in research on other psychological behaviors, populations such as the elderly, and gender studies.

PSYCHIATRY RESEARCH (2022)

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Review Biodiversity Conservation

Global trends and characteristics of ecological security research in the early 21st century: A literature review and bibliometric analysis

Chenli Liu et al.

Summary: With the worsening of environmental problems, ecological security has become a global concern in the 21st century. This study used bibliometric analysis to review the progress of global research in ecological security from 2000 to 2020. The results showed that China was the leading country in terms of research, with the Chinese Academy of Sciences being the most productive institution. The focal topics have shifted from ecological security assessment to ecological security patterns.

ECOLOGICAL INDICATORS (2022)

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Review Neurosciences

Alzheimer's Disease: Key Insights from Two Decades of Clinical Trial Failures

C. Kwon Kim et al.

Summary: This review examines the failures in Alzheimer's disease drug development over the past two decades and derives key insights for future drug development. The success rate of AD drugs has been only 2.0% since 2003, with reasons for clinical trial failures including lack of evidence to initiate pivotal trials and design shortcomings. It is recommended that future AD therapeutic development should adhere to rational drug development principles.

JOURNAL OF ALZHEIMERS DISEASE (2022)

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Article Genetics & Heredity

New insights into the genetic etiology of Alzheimer's disease and related dementias

Celine Bellenguez et al.

Summary: By characterizing the genetic landscape of Alzheimer's disease and related dementias, new loci have been identified and a new genetic risk score associated with the risk of future Alzheimer's disease and dementia has been generated.

NATURE GENETICS (2022)

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Article Neurosciences

Regional A13-tau interactions promote onset and acceleration of Alzheimer's disease tau

Wha Jin Lee et al.

Summary: This study identified two interactions between amyloid-beta and tau associated with the onset and propagation of tau spreading in living humans, addressing long-standing questions regarding the topographical dissimilarity between early amyloid-beta and tau deposition.

NEURON (2022)

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News Item Medicine, General & Internal

Much Anticipated Alzheimer Disease Prevention Trial Finds No Clinical Benefit From Drug Targeting Amyloid; Highlights Need to Consider Other Approaches

Rita Rubin

Summary: This article highlights the latest research findings on the treatment and prevention of Alzheimer's disease.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Article Clinical Neurology

Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease A Randomized Clinical Trial

Edmond Teng et al.

Summary: In this study, semorinemab did not slow clinical progression in patients with prodromal to mild AD, but demonstrated good safety. Further research is needed to determine the clinical utility of anti-tau antibody therapy.

JAMA NEUROLOGY (2022)

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Article Clinical Neurology

2022 Alzheimer's disease facts and figures

Joseph Gaugler et al.

Summary: This article discusses the impact of Alzheimer's disease on public health, including its incidence, prevalence, mortality and morbidity rates, healthcare costs and caregivers' burden. It also addresses the perspectives of consumers and primary care physicians on mild cognitive impairment (MCI) and the need for improved awareness, diagnosis, and treatment. The article emphasizes the increasing number of individuals living with Alzheimer's and the challenges faced by caregivers and healthcare providers, particularly during the COVID-19 pandemic.

ALZHEIMERS & DEMENTIA (2022)

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Review Clinical Neurology

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches

Alberto Serrano-Pozo et al.

Summary: The APOE ε4 allele and ε2 allele are respectively the strongest genetic risk factor and protective factor for Alzheimer's disease. While therapies targeting APOE are currently unavailable, recent research has expanded our understanding of APOE pathogenesis to include multiple pathological processes, offering valuable insights for therapy development.

LANCET NEUROLOGY (2021)

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Editorial Material Dentistry, Oral Surgery & Medicine

A bibliometric analysis of periodontology

Paras Ahmad et al.

Summary: This bibliometric study found that periodontal/implant articles were consistently cited and grew in impact factor over the years, with core periodontal journals also increasing in influence within the dental field.

PERIODONTOLOGY 2000 (2021)

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Article Genetics & Heredity

Hippocampal transcriptome-wide association study and neurobiological pathway analysis for Alzheimer's disease

Nana Liu et al.

Summary: The study identifies 24 genes associated with Alzheimer's disease (AD) in hippocampal tissue and shows these genes are related to AD-related biological processes. It also demonstrates that hippocampal volume mediates the effects of hippocampal gene expression of QPCTL and ERCC2 on AD. These findings contribute to a better understanding of the genetic and neural mechanisms of AD.

PLOS GENETICS (2021)

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Editorial Material Clinical Neurology

Isoform-dependent APOE secretion modulates neuroinflammation

Philip Hasel et al.

NATURE REVIEWS NEUROLOGY (2021)

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Article Medicine, General & Internal

Bibliometric Analysis of Neurology Articles Published in General Medicine Journals

Mitch Wilson et al.

Summary: A significant portion of neurology literature is published in general medicine journals. This study analyzed the publication patterns of neurology articles in top general medicine journals over a 10-year period. Neurology-based articles were found to be published more frequently in comparison to other medical specialties.

JAMA NETWORK OPEN (2021)

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Article Immunology

Global research trends of Apolipoprotein E in central nervous system: A scientometric analysis

Kai Gong et al.

Summary: The research on APOE in CNS is not trendy over the past two decades, despite the involvement of numerous funds, organizations, and scholars. There is a lack of close cooperation between top teams in this field and others worldwide. New ideas may reignite scholars' interest in studying APOE in CNS, with a potential focus on the crosstalk between ApoE and inflammasome in future research.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Clinical Neurology

Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group

Bruno Dubois et al.

Summary: The use of biomarkers in the diagnosis of Alzheimer's disease has limitations and should be used cautiously in a clinical setting, restricted to individuals with specific phenotypes and positive biomarkers. Biomarker-positive cognitively unimpaired individuals should be considered at-risk for progression to Alzheimer's disease.

LANCET NEUROLOGY (2021)

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Editorial Material Pharmacology & Pharmacy

Pharmacological Research: A bibliometric analysis from 1989 to 2019

Waseem Hassan et al.

PHARMACOLOGICAL RESEARCH (2021)

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Review Clinical Neurology

Microglia and its Genetics in Alzheimer's Disease

Xinyan Liang et al.

Summary: Alzheimer's Disease is the most prevalent form of dementia worldwide, with neuroinflammation playing a key role in its pathogenesis and progression. Microglia, as the main innate immune cell type in the central nervous system, are crucial for regulating neuroinflammation and have been linked to AD risk genes.

CURRENT ALZHEIMER RESEARCH (2021)

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Correction Clinical Neurology

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches (vol 20, pg 68, 2021)

Alberto Serrano-Pozo et al.

LANCET NEUROLOGY (2021)

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Article Multidisciplinary Sciences

Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study

Eric M. Reiman et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline

Axel Montagne et al.

NATURE (2020)

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Article Immunology

Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer's disease

Nicolas R. Barthelemy et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Genetics & Heredity

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Brian W. Kunkle et al.

NATURE GENETICS (2019)

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Article Multidisciplinary Sciences

Single-cell transcriptomic analysis of Alzheimer's disease

Hansruedi Mathys et al.

NATURE (2019)

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Review Clinical Neurology

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Yu Yamazaki et al.

NATURE REVIEWS NEUROLOGY (2019)

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Article Genetics & Heredity

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk

Iris E. Jansen et al.

NATURE GENETICS (2019)

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Review Clinical Neurology

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

Clifford R. Jack et al.

ALZHEIMERS & DEMENTIA (2018)

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Article Multidisciplinary Sciences

High performance plasma amyloid-β biomarkers for Alzheimer's disease

Akinori Nakamura et al.

NATURE (2018)

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Article Immunology

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Susanne Krasemann et al.

IMMUNITY (2017)

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Article Neurosciences

Four Decades of Research in Alzheimer's Disease (1975-2014): A Bibliometric and Scientometric Analysis

Alberto Serrano-Pozo et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

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Review Medicine, General & Internal

Dementia prevention, intervention, and care

Gill Livingston et al.

LANCET (2017)

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Article Multidisciplinary Sciences

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

Yang Shi et al.

NATURE (2017)

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Article Clinical Neurology

Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease A Meta-analysis

Scott C. Neu et al.

JAMA NEUROLOGY (2017)

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Article Computer Science, Interdisciplinary Applications

bibliometrix: An R-tool for comprehensive science mapping analysis

Massimo Aria et al.

JOURNAL OF INFORMETRICS (2017)

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Article Cell Biology

IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis

Sebastian Theurich et al.

CELL METABOLISM (2017)

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Review Medicine, Research & Experimental

The amyloid hypothesis of Alzheimer's disease at 25years

Dennis J. Selkoe et al.

EMBO MOLECULAR MEDICINE (2016)

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Article Clinical Neurology

Defeating Alzheimer's disease and other dementias: a priority for European science and society

Bengt Winblad et al.

LANCET NEUROLOGY (2016)

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Article Medicine, General & Internal

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

Stephen Salloway et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Article Clinical Neurology

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

Clifford R. Jack et al.

LANCET NEUROLOGY (2013)

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Article Computer Science, Interdisciplinary Applications

Software survey: VOSviewer, a computer program for bibliometric mapping

Nees Jan van Eck et al.

SCIENTOMETRICS (2010)

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Article Computer Science, Information Systems

CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature

CM Chen

JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY (2006)

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