4.5 Article

Construction and validation of a chemokine family-based signature for the prediction of prognosis and therapeutic response in colon cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

The immunosuppressive and pro-tumor functions of CCL18 at the tumor microenvironment

Ana Patricia Cardoso et al.

Summary: CCL18 is an important chemokine in the tumor microenvironment, playing a key role in promoting tumor progression. Although there is potential for it to be used as a biomarker or therapeutic target, its functions in the context of cancer are still poorly explored.

CYTOKINE & GROWTH FACTOR REVIEWS (2021)

Review Immunology

CCR4 in cutaneous T-cell lymphoma: Therapeutic targeting of a pathogenic driver

Jan P. Nicolay et al.

Summary: New treatments are needed for patients with CTCL, especially for advanced MF and SS, and CCR4 has been identified as a promising therapeutic target. One approved drug, mogamulizumab, is effective for relapsed/refractory MF and SS, with other CCR4-targeted therapies under evaluation.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

Article Oncology

Enfortumab vedotin after PD-1 or PD-L1 inhibitors in cisplatin-ineligible patients with advanced urothelial carcinoma (EV-201): a multicentre, single-arm, phase 2 trial

Evan Y. Yu et al.

Summary: Enfortumab vedotin showed promising efficacy in cisplatin-ineligible patients with locally advanced or metastatic urothelial carcinoma previously treated with PD-1 or PD-L1 inhibitors, providing a new treatment option for a patient population with a high unmet need.

LANCET ONCOLOGY (2021)

Article Oncology

CX3CL1 Overexpression Prevents the Formation of Lung Metastases in Trastuzumab-Treated MDA-MB-453-Based Humanized Tumor Mice (HTM)

Anja Kathrin Wege et al.

Summary: In HER2-positive breast cancer patients, CX3CL1 may predict the response to trastuzumab therapy. Overexpression of CX3CL1 enhances the efficacy of trastuzumab treatment, but shedding inhibitors do not enhance the treatment effect. Further investigation is warranted in a large cohort of patients.

CANCERS (2021)

Review Biochemistry & Molecular Biology

Chemokine-Directed Tumor Microenvironment Modulation in Cancer Immunotherapy

Pedro Bule et al.

Summary: Chemokines play a crucial role in cancer development by influencing various processes such as angiogenesis, metastasis, and stemness. The chemokine network has emerged as a potential target for immunotherapy and may have therapeutic effects when used alone or in combination with other treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Medicine, General & Internal

Effect of Camrelizumab vs Placebo Added to Chemotherapy on Survival and Progression-Free Survival in Patients With Advanced or Metastatic Esophageal Squamous Cell Carcinoma: The ESCORT-1st Randomized Clinical Trial

Huiyan Luo et al.

Summary: The addition of camrelizumab to chemotherapy significantly improved overall survival and progression-free survival in patients with advanced or metastatic esophageal squamous cell carcinoma. This treatment strategy could enhance the overall survival rate of patients.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Medicine, General & Internal

Pembrolizumab plus chemotherapy versus chemotherapy alone for first-line treatment of advanced oesophageal cancer (KEYNOTE-590): a randomised, placebo-controlled, phase 3 study

Jong-Mu Sun et al.

Summary: This study aimed to evaluate the antitumor activity of pembrolizumab plus chemotherapy versus chemotherapy alone as first-line treatment in advanced esophageal cancer. Results showed that pembrolizumab plus chemotherapy significantly improved overall survival and progression-free survival in patients with esophageal squamous cell carcinoma.

LANCET (2021)

Article Medicine, General & Internal

First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial

Yelena Y. Janjigian et al.

Summary: Nivolumab plus chemotherapy showed superior overall survival and progression-free survival compared to chemotherapy alone in previously untreated patients with advanced gastric, gastro-oesophageal junction, or oesophageal adenocarcinoma, indicating it as a new standard first-line treatment option with acceptable safety profile.

LANCET (2021)

Article Endocrinology & Metabolism

Immune checkpoint B7-H3 protein expression is associated with poor outcome and androgen receptor status in prostate cancer

Caroline E. Nunes-Xavier et al.

Summary: This study identified distinct clinical relevance of the two immune checkpoint proteins PD-L1 and B7-H3 in prostate cancer, with B7-H3 potentially serving as a significant therapeutic target.

PROSTATE (2021)

Article Multidisciplinary Sciences

The PEMDAC phase 2 study of pembrolizumab and entinostat in patients with metastatic uveal melanoma

Lars Ny et al.

Summary: The combination of HDAC inhibitor entinostat with anti-PD-1 antibody pembrolizumab shows durable responses in a subset of patients with metastatic uveal melanoma. Factors such as wildtype BAP1 gene, low tumor burden, and iris melanoma may be associated with better treatment response and longer survival.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Nodal immune flare mimics nodal disease progression following neoadjuvant immune checkpoint inhibitors in non-small cell lung cancer

Tina Cascone et al.

Summary: This study reported the occurrence of nodal immune flare in patients with non-small cell lung cancer following neoadjuvant immune checkpoint inhibitors treatment, characterized by apparent radiological cancer progression in the absence of cancer and presence of non-caseating granulomas. Nodal immune flare is associated with an inflamed nodal immune microenvironment and specific gut microbiota, highlighting the importance of pathological examination in distinguishing it from true nodal progression for appropriate clinical management.

NATURE COMMUNICATIONS (2021)

Article Biotechnology & Applied Microbiology

SEMA4D Knockdown Attenuates β-Catenin-Dependent Tumor Progression in Colorectal Cancer

Mahsa Rezaeepoor et al.

Summary: This study demonstrates that silencing the SEMA4D gene can significantly inhibit the biological properties of colorectal cancer cells, including cell migration, E-cadherin, beta-catenin expression, and induction of apoptosis. This suggests a promising alternative for cancer therapy by targeting multiple pathways involved in cancer through SEMA4D suppression.

BIOMED RESEARCH INTERNATIONAL (2021)

Article Oncology

Single-cell analyses reveal suppressive tumor microenvironment of human colorectal cancer

Yan Mei et al.

Summary: This study comprehensively characterized the transcriptomes of single cells from 12 treatment-naive colorectal cancer patients, identifying differences in cell clusters and their association with therapeutic responses. Novel immune cell subtypes associated with colorectal cancer were also discovered, providing a rich resource for further research. Additionally, expanded T-cell clusters linked to high tumor mutational burden status were identified, enhancing understanding of the tumor microenvironment.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Article Immunology

PRDM16 suppresses HIF-targeted gene expression in kidney cancer

Anirban Kundu et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Review Gastroenterology & Hepatology

Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies

NaNa Keum et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)