期刊
NEPHROLOGY
卷 21, 期 2, 页码 81-85出版社
WILEY
DOI: 10.1111/nep.12652
关键词
autoimmunity; Foxp3; Tregs
资金
- National Health and Medical Research Council of Australia (NHMRC) [632519, 1030463]
Regulatory T cells (Tregs) have been recognized as having a major role in maintaining peripheral tolerance and preventing and limiting autoimmune and chronic inflammatory diseases. Tregs derive from the thymus and also develop peripherally. In this review, we discuss recent progress in our understanding of the basic mechanisms involved in Treg development and function in protecting against autoimmunity in the periphery, including thymic selection, peripheral induction and the many mechanisms of Treg suppression. Specifically in kidney disease, Tregs have been shown to play a role in limiting injury and may potentially have a therapeutic role.
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