4.7 Article

Psychedelics and neonihilism: connectedness in a meaningless world

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

More than meets the eye: The role of sensory dimensions in psychedelic brain dynamics, experience, and therapeutics

Marco Aqil et al.

Summary: The article reviews the current scientific and clinical interest in psychedelics and highlights the need to reevaluate the role of low-level sensory dimensions in psychedelic states. It suggests that integrating the effects on sensory dimensions into existing models is crucial for understanding the therapeutic benefits of psychedelics.

NEUROPHARMACOLOGY (2023)

Review Clinical Neurology

Default Mode Network Modulation by Psychedelics: A Systematic Review

James J. Gattuso et al.

Summary: Psychedelics produce vivid hallucinations and profound psychological experiences. They modulate the Default Mode Network (DMN) in the brain, which is involved in self-referencing, mind wandering, and autobiographical memories. Altered connectivity in the DMN is associated with various neuropsychiatric conditions. This article aims to provide a comprehensive overview of how major psychedelic agents modulate the DMN and how the DMN is related to the therapeutic potential of psychedelics.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2023)

Review Clinical Neurology

Adverse effects of psychedelics: From anecdotes and misinformation to systematic science

Anne K. Schlag et al.

Summary: This narrative review examines the evidence for potential harms of classic psychedelics and emphasizes the importance of adhering to high safety and ethical standards. The review finds that medical risks are often minimal and many negative perceptions of psychological risks lack scientific support.

JOURNAL OF PSYCHOPHARMACOLOGY (2022)

Article Psychology, Multidisciplinary

Microdosing as a Response to the Meaning Crisis: A Qualitative Analysis

Rotem Petranker et al.

Summary: The use of psychedelic substances, including microdosing, has been increasing in both humanistic and mainstream clinical research. This study aims to identify emergent themes in qualitative reports regarding the experience of microdosing and propose future research directions. The results suggest that even at low doses, psychedelics can provide a sense of meaning.

JOURNAL OF HUMANISTIC PSYCHOLOGY (2022)

Article Psychology, Multidisciplinary

Presence, Trust, and Empathy: Preferred Characteristics of Psychedelic Carers

Sascha Thal et al.

Summary: Research into psychedelic-assisted psychotherapy is increasing, but current guidelines are based on earlier research and trans-disciplinary knowledge. This study analyzed online discussion forum posts to explore the preferences of psychedelic users for characteristics they value in their carers in nonclinical contexts. The findings identified presence, trust, and empathy as key characteristics preferred by psychedelic users, which can inform and enhance current understandings of effective therapeutic outcomes.

JOURNAL OF HUMANISTIC PSYCHOLOGY (2022)

Article Neurosciences

The Watts Connectedness Scale: a new scale for measuring a sense of connectedness to self, others, and world

Rosalind Watts et al.

Summary: Psychological construct of 'connectedness' refers to the feeling of being connected to self, others, and the wider world. This study aimed to develop and validate the Watts Connectedness Scale (WCS), which measures connectedness across multiple domains. The results showed that the WCS has good internal consistency and construct validity. Post-psychedelic use, individuals experienced significant increases in total connectedness scores and its subscales. Psilocybin therapy was associated with greater improvements in WCS scores compared to escitalopram therapy.

PSYCHOPHARMACOLOGY (2022)

Review Psychiatry

Psychedelics, Mystical Experience, and Therapeutic Efficacy: A Systematic Review

Kwonmok Ko et al.

Summary: The mystical experience is a potential psychological mechanism that can influence outcomes in psychedelic therapy. It has been found to be closely linked to symptom reduction and improved quality of life. However, many existing studies have limitations such as small sample size, lack of diversity, and susceptibility to bias. Future research should focus on larger samples with greater diversity and randomized designs to explore the nature and predictors of the mystical experience.

FRONTIERS IN PSYCHIATRY (2022)

Article Psychology, Multidisciplinary

Psychedelic integration: An analysis of the concept and its practice

Geoff J. J. Bathje et al.

Summary: This manuscript presents the first comprehensive review and concept analysis of definitions, practices, and models of psychedelic integration. By providing a synthesized definition, model, and comprehensive summary of integration practices, it aims to bring clarity to the subject.

FRONTIERS IN PSYCHOLOGY (2022)

Article Substance Abuse

Manifest your desires: Psychedelics and the self-help industry

Patric Plesa et al.

Summary: A psychedelic industrial complex is emerging, with potential benefits and risks yet to be fully understood. Some entrepreneurs have already started marketing psychedelic advice, but there are concerns about exaggerated claims. We propose guidelines for responsible research, therapy, and policy to address these concerns.

INTERNATIONAL JOURNAL OF DRUG POLICY (2022)

Article Neurosciences

Set and setting in microdosing: an oft-overlooked principle

Ido Hartogsohn et al.

Summary: This paper challenges the assumption that set and setting are not important in the context of microdosing psychedelics and argues for their crucial relevance. By discussing set and setting theory and placebo theory, it explains the role of set and setting in determining the outcomes of microdosing and helps explain some contradictory results.

PSYCHOPHARMACOLOGY (2022)

Article Multidisciplinary Sciences

Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain's control energy landscape

S. Parker Singleton et al.

Summary: The authors used network control theory and functional MRI data to show that serotonergic psychedelic drugs like LSD and psilocybin flatten the dynamic landscape of the brain, allowing for easier state transitions and more diverse brain activity over time. These drugs alter subjective experience through serotonin 2a (5-HT2a) receptor agonism, which is associated with increased entropy in brain activity. This increase in entropy is hypothesized to be due to a flattening of the brain's control energy landscape, making transitions between brain states more energy efficient.

NATURE COMMUNICATIONS (2022)

Article Anthropology

Dark Side of the Shroom: Erasing Indigenous and Counterculture Wisdoms with Psychedelic Capitalism, and the Open Source Alternative or, A Manifesto for Psychonauts

Nese Devenot et al.

Summary: Psychedelic or ecodelic medicines have gained importance in discussions about mental health in the US, being used for the treatment of various illnesses. This has led to well-funded biotech companies going public with multimillion-dollar IPOs. Scholars, activists, and practitioners are advocating for a culture that provides access to these medicines in a safe and affordable manner, while respecting the traditional knowledge associated with them and opposing the corporatization and standardization of the field.

ANTHROPOLOGY OF CONSCIOUSNESS (2022)

Article Psychiatry

Mental health and the global climate crisis

Carlos Corvalan et al.

Summary: Climate change has significant impacts on mental health, urgent actions are needed to integrate climate change considerations into mental health policies and programs, and address mental health impacts through multisectoral and community-based approaches.

EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES (2022)

Article Management

Mindfulness-it's not what you think: Toward critical reconciliation with progressive self-development practices

Erik Mygind du Plessis et al.

Summary: This paper discusses the perception of mindfulness meditation in critical management studies and social sciences, and challenges this perception by exploring the practice of activists during Occupy Wall Street. By introducing the concept of resonance, the paper aims to explore the potential of progressive self-development practices.

ORGANIZATION (2022)

Review Health Care Sciences & Services

The Use of Classic Hallucinogens/Psychedelics in a Therapeutic Context: Healthcare Policy Opportunities and Challenges

Rafael Guimaraes dos Santos et al.

Summary: Psychedelics act by agonizing serotonergic 5-HT2A receptors, leading to changes in perception, cognitive processes, and mood. Despite historical use in ritual contexts, these substances have gained interest in science and industry for their potential antidepressant, anxiolytic, and antiaddictive effects.

RISK MANAGEMENT AND HEALTHCARE POLICY (2021)

Article Psychology, Multidisciplinary

Psychedelics as Tools for Belief Transmission. Set, Setting, Suggestibility, and Persuasion in the Ritual Use of Hallucinogens

David Dupuis

Summary: The use of psychedelics in collective rituals by indigenous groups suggests their power in social affiliation, enculturation, and belief transmission. However, the increasing feelings of collective belonging and transmission of cultural values raise complex ethical questions in the current global context, especially in Euro-American societies.

FRONTIERS IN PSYCHOLOGY (2021)

Article Psychology, Multidisciplinary

Examining Psychedelic-Induced Changes in Social Functioning and Connectedness in a Naturalistic Online Sample Using the Five-Factor Model of Personality

Brandon Weiss et al.

Summary: This study examines the potential impact of psychedelic substances on personality traits and social connectedness. Findings suggest that the use of psychedelics is associated with reductions in Neuroticism, increases in Agreeableness, and improvements in social connectedness. While some factors had limited moderation effects, baseline levels of Neuroticism, perspective taking, and social connectedness showed tentative indications of amplifying adaptive effects on personality traits.

FRONTIERS IN PSYCHOLOGY (2021)

Article Clinical Neurology

Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience

Martin K. Madsen et al.

Summary: The novel therapeutic psilocybin exerts its psychedelic effects by engaging cerebral serotonergic targets with its active metabolite psilocin. The serotonin 2A receptor plays a critical role in altering neural processes, leading to increased entropy, reduced network integrity, and decreased segregation between brain networks. Psilocin is shown to shape the time course and magnitude of changes in cerebral functional architecture and subjective experience, providing novel insight into the neurobiological mechanisms underlying the psychedelic experience and consciousness.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2021)

Article Chemistry, Medicinal

The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects

David B. Yaden et al.

Summary: The subjective effects of psychedelics are crucial for their lasting benefits, accounting for the majority of their therapeutic outcomes.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

Article Education & Educational Research

Behind the Masks: Experiences of Mental Health Practitioners of Color During the COVID-19 Pandemic

Adriana S. Miu et al.

ACADEMIC PSYCHIATRY (2021)

Article Substance Abuse

People of color in North America report improvements in racial trauma and mental health symptoms following psychedelic experiences

Monnica T. Williams et al.

Summary: The study revealed that psychedelics significantly reduced symptoms of racial trauma among black, indigenous, and people of color (BIPOC), leading to decreases in depression, anxiety, and stress. Furthermore, there was a significant relationship between acute psychedelic effects and decreases in subsequent psychopathology, suggesting the potential efficacy of psychedelic-assisted therapy for individuals with a history of race-based trauma.

DRUGS-EDUCATION PREVENTION AND POLICY (2021)

Article Multidisciplinary Sciences

Transformative experience and social connectedness mediate the mood-enhancing effects of psychedelic use in naturalistic settings

Matthias Forstmann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Biotechnology & Applied Microbiology

Psilocybin: from ancient magic to modern medicine

David E. Nichols

JOURNAL OF ANTIBIOTICS (2020)

Article Clinical Neurology

Subacute effects of the psychedelic ayahuasca on the salience and default mode networks

Lorenzo Pasquini et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2020)

Editorial Material Psychiatry

Digital Mental Health: The Answer to the Global Mental Health Crisis?

Brittany N. Rudd et al.

JMIR MENTAL HEALTH (2020)

Article Integrative & Complementary Medicine

Altered Default Mode Network and Salience Network Functional Connectivity in Patients with Generalized Anxiety Disorders: An ICA-Based Resting- State fMRI Study

Hang Xiong et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

Letter Medicine, General & Internal

Psilocybin-assisted group therapy: A new hope for demoralization

Peter S. Hendricks

ECLINICALMEDICINE (2020)

Article Psychology, Clinical

Anxiety disorders, climate change, and the challenges ahead: Introduction to the special issue

Steven Taylor

JOURNAL OF ANXIETY DISORDERS (2020)

Article Psychology, Multidisciplinary

Psychedelic Research and the Need for Transparency: Polishing Alice's Looking Glass

Rotem Petranker et al.

FRONTIERS IN PSYCHOLOGY (2020)

Review Psychology, Clinical

The use of the psychological flexibility model to support psychedelic assisted therapy

Rosalind Watts et al.

JOURNAL OF CONTEXTUAL BEHAVIORAL SCIENCE (2020)

Review Pharmacology & Pharmacy

REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics

R. L. Carhart-Harris et al.

PHARMACOLOGICAL REVIEWS (2019)

Review Psychiatry

How do psychedelics work?

Robin L. Carhart-Harris

CURRENT OPINION IN PSYCHIATRY (2019)

Review Psychology, Clinical

Psychedelic-Assisted Group Therapy: A Systematic Review

Alexander Trope et al.

JOURNAL OF PSYCHOACTIVE DRUGS (2019)

Article Neurosciences

Meditation Benefits and Drawbacks: Empirical Codebook and Implications for Teaching

Thomas Anderson et al.

JOURNAL OF COGNITIVE ENHANCEMENT (2019)

Review Psychiatry

Defining and Evaluating Overdiagnosis in Mental Health: A Meta-Research Review

Brett Thombs et al.

PSYCHOTHERAPY AND PSYCHOSOMATICS (2019)

Editorial Material Neurosciences

Psychedelics and connectedness

R. L. Carhart-Harris et al.

PSYCHOPHARMACOLOGY (2018)

Article Psychology, Multidisciplinary

DMT Models the Near-Death Experience

Christopher Timmermann et al.

FRONTIERS IN PSYCHOLOGY (2018)

Article Education & Educational Research

Fostering Personal Meaning and Self-relevance: A Self-Determination Theory Perspective on Internalization

Maarten Vansteenkiste et al.

JOURNAL OF EXPERIMENTAL EDUCATION (2018)

Article Psychology, Multidisciplinary

Homo neoliberalus: From personality to forms of subjectivity

Thomas Teo

THEORY & PSYCHOLOGY (2018)

Article Psychology, Clinical

Mental Health Concerns in the Digital Age

David A. Scott et al.

INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION (2017)

Article Psychology, Multidisciplinary

Patients' Accounts of Increased Connectedness and Acceptance After Psilocybin for Treatment-Resistant Depression

Rosalind Watts et al.

JOURNAL OF HUMANISTIC PSYCHOLOGY (2017)

Article Psychology, Clinical

Psychedelics, Personality and Political Perspectives

Matthew M. Nour et al.

JOURNAL OF PSYCHOACTIVE DRUGS (2017)

Article Biochemistry & Molecular Biology

The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation

Katrin H. Preller et al.

CURRENT BIOLOGY (2017)

Article Health Care Sciences & Services

Getting clearer on overdiagnosis

Wendy A. Rogers et al.

JOURNAL OF EVALUATION IN CLINICAL PRACTICE (2016)

Article Multidisciplinary Sciences

Neural correlates of the LSD experience revealed by multimodal neuroimaging

Robin L. Carhart-Harris et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Pharmacology & Pharmacy

Psychedelics

David E. Nichols

PHARMACOLOGICAL REVIEWS (2016)

Article Philosophy

Groups and Oppression

Elanor Taylor

HYPATIA-A JOURNAL OF FEMINIST PHILOSOPHY (2016)

Review Public, Environmental & Occupational Health

Income inequality and health: A causal review

Kate E. Pickett et al.

SOCIAL SCIENCE & MEDICINE (2015)

Editorial Material Medicine, General & Internal

Preventing overdiagnosis: how to stop harming the healthy

Ray Moynihan et al.

BMJ-BRITISH MEDICAL JOURNAL (2012)

Review Psychology, Clinical

The potential impact of mindfulness on exposure and extinction learning in anxiety disorders

Michael Treanor

CLINICAL PSYCHOLOGY REVIEW (2011)

Article Multidisciplinary Sciences

Psychometric Evaluation of the Altered States of Consciousness Rating Scale (OAV)

Erich Studerus et al.

PLOS ONE (2010)

Article Public, Environmental & Occupational Health

Negotiating the neurochemical self: anti-depressant consumption in women's recovery from depression

Simone Fullagar

HEALTH (2009)

Article Psychology, Multidisciplinary

The Sources of Meaning and Meaning in Life Questionnaire (SoMe): Relations to demographics and well-being

Tatjana Schnell

JOURNAL OF POSITIVE PSYCHOLOGY (2009)

Article Social Issues

Near-death experiences and spirituality

Bruce Greyson