期刊
FOOD CHEMISTRY-X
卷 19, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fochx.2023.100765
关键词
Fructo-oligosaccharide; Red radish anthocyanins; Bioavailability; Gut microbiota; Antioxidant activity
The bioavailability of anthocyanins in red radish (ARR) is low. This study found that co-ingestion of fructo-oligosaccharide (FOS) with ARR increased the levels of pelargonidin, cyanidin, and pelargonidin-3-glucoside in mouse serum and enhanced hepatic antioxidant activity. The 16S RNA sequencing identified Bacteroides genus as playing a crucial role in FOS-mediated elevation of ARR bioavailability. These findings suggest that combining FOS and ARR could be an effective strategy to enhance the bioactivity of ARR.
The anthocyanins from red radish (ARR) rich in polyglycosylated pelargonidin glucosides were used as pigment. However, bioavailability of anthocyanins was considered at low level. This work examined the intensive effects of fructo-oligosaccharide (FOS) on ARR bioavailability. Pelargonidin, cyanidin and pelargonidin-3-glucoside showed higher level in serum of mice fed with FOS together with ARR for 8 weeks than that fed with only ARR. Co-ingestion of FOS and ARR more effectively elevated the hepatic antioxidant activity by increase in total antioxidant capacity and activities of superoxide dismutase and glutathione peroxidase when compared with intake of ARR. FOS also markedly increased pelargonidin level in cecum of mice. 16S RNA sequencing found that Bacteroides genus play an important role in FOS elevating bioavailability of ARR. Fecal bacteria transplantation verified the positive effects of FOS on ARR bioavailability. These results suggested that combined ingestion of FOS and ARR is effective strategy for bioactivity of ARR.
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