4.8 Article

3D printing of piezoelectric and bioactive barium titanate-bioactive glass scaffolds for bone tissue engineering

期刊

MATERIALS TODAY BIO
卷 21, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.mtbio.2023.100719

关键词

Bone regeneration; 3D printing; Piezoelectricity; Bioactivity; Barium titanate

向作者/读者索取更多资源

Bone healing is a complex process that involves various factors such as mechanical, chemical, and electrical cues. Scientists worldwide aim to create synthetic biomaterials that combine these factors to achieve tailored and controlled tissue regeneration. This study presents a method using additive manufacturing techniques to create macroporous biomaterial scaffolds made of a piezoelectric and bioactive ceramic-crystallized glass composite. These scaffolds show suitable mechanical strength, bioactivity, and piezoelectric properties, making them promising candidates for bone tissue engineering.
Bone healing is a complex process orchestrated by various factors, such as mechanical, chemical and electrical cues. Creating synthetic biomaterials that combine several of these factors leading to tailored and controlled tissue regeneration, is the goal of scientists worldwide. Among those factors is piezoelectricity which creates a physiological electrical microenvironment that plays an important role in stimulating bone cells and fostering bone regeneration. However, only a limited number of studies have addressed the potential of combining piezoelectric biomaterials with state-of-the-art fabrication methods to fabricate tailored scaffolds for bone tissue engineering. Here, we present an approach that takes advantage of modern additive manufacturing techniques to create macroporous biomaterial scaffolds based on a piezoelectric and bioactive ceramic-crystallised glass composite. Using binder jetting, scaffolds made of barium titanate and 45S5 bioactive glass are fabricated and extensively characterised with respect to their physical and functional properties. The 3D-printed ceramic crystallised glass composite scaffolds show both suitable mechanical strength and bioactive behaviour, as represented by the accumulation of bone-like calcium phosphate on the surface. Piezoelectric scaffolds that mimic or even surpass bone with piezoelectric constants ranging from 1 to 21 pC/N are achieved, depending on the composition of the composite. Using MC3T3-E1 osteoblast precursor cells, the scaffolds show high cytocompatibility coupled with cell attachment and proliferation, rendering the barium titanate/45S5 ceramic crystallised glass composites promising candidates for bone tissue engineering.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据