期刊
FORENSIC CHEMISTRY
卷 35, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.forc.2023.100523
关键词
Novel psychoactive substances; Synthetic cathinones; bk-PBDB; GC-EI-MS; NMR
This paper reports the detection of bk-PBDB (putylone) in solid dosage forms for the first time in the UK, confirmed by analytical profiling techniques. A validated GC-EI-MS method was developed for routine quantification of bk-PBDB in forensic samples, showing that the seized tablets contained a mixture of bk-PBDB and caffeine.
Synthetic cathinones are a continually evolving family of illicit drugs, with novel analogues frequently being detected. This paper reports the detection of 1-(1,3-benzodioxol-5-yl)-2-(propylamino)butan-1-one, bk-PBDB (putylone), within solid dosage forms (tablets) seized by law enforcement for the first time in the United Kingdom. The identity of the compound was confirmed via the synthesis of a pure bk-PBDB reference standard and direct spectral comparison by 1H NMR and GC-EI-MS analysis. A full analytical profiling of bk-PBDB by nuclear magnetic resonance (NMR), attenuated total reflection Fourier-transform infrared (FTIR) spectroscopy and gas chromatography-electron ionisation-mass spectrometry (GC-EI-MS) is reported and shows good concordance between the seized sample and the reference standard. A validated GC-EI-MS method for the routine quantification of the cathinone in bulk forensic samples (LOD: 0.09 & mu;g/mL, LOQ: 0.26 & mu;g/mL) was also developed and using this method, the seized tablets were determined to contain a mixture of bk-PBDB (130.6-135.5 mg/tablet) and caffeine (40.2-43.4 mg/tablet) respectively.
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