4.4 Article

Intraperitoneal Injection of Human Ferritin Heavy Chain Attenuates the Atherosclerotic Process in APOE-Knockout Mice

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Food Science & Technology

A Dual Function of Ferritin (Animal and Plant): Its Holo Form for Iron Supplementation and Apo Form for Delivery Systems

Xiaoxi Chang et al.

Summary: Ferritins are iron storage proteins with detoxification functions that are widely distributed in animals and plants. They have two forms: holo and apo. Holo ferritin is a safe and efficient iron supplementation factor, while apo ferritin can be a promising carrier for delivering nutrients and bioactive compounds. The functions of ferritins from animal and plant sources have been extensively studied in various fields. This review summarizes the structure and functions of ferritins, recent advances in iron supplementation and nutrient delivery, and discusses the challenges and future developments for multifunctional applications of ferritins.

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY (2023)

Review Cardiac & Cardiovascular Systems

The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease

Xuexian Fang et al.

Summary: Iron homeostasis is crucial for proper cardiac function, and iron imbalance is a common factor in various cardiovascular diseases. Ferroptosis, an iron-dependent regulated cell death, has been increasingly recognized as an important process underlying the pathogenesis and progression of cardiovascular diseases. Understanding the mechanisms of iron metabolism and ferroptosis regulation in cardiomyocytes may lead to improvements in disease management.

NATURE REVIEWS CARDIOLOGY (2023)

Review Cardiac & Cardiovascular Systems

HDL Function and Atherosclerosis: Reactive Dicarbonyls as Promising Targets of Therapy

MacRae F. Linton et al.

Summary: Epidemiologic studies have shown that HDL-C levels are inversely related to ASCVD, suggesting that HDL-C is a major risk factor for ASCVD. However, clinical trials have questioned the role of HDL-C in mediating ASCVD risk. Progress in understanding the composition of HDL particles has revealed that HDL-C levels do not necessarily reflect HDL function. HDL has been found to have antiatherogenic functions, such as reverse cholesterol transport and suppression of inflammation, but its oxidative modifications can lead to dysfunction and inflammation.

CIRCULATION RESEARCH (2023)

Review Cardiac & Cardiovascular Systems

Targeting the CCL2-CCR2 axis for atheroprotection

Marios K. Georgakis et al.

Summary: Decades of research have established atherosclerosis as an inflammatory disease. Clinical trials have shown the efficacy of anti-inflammatory strategies in reducing cardiovascular events, but there is a need for new anti-inflammatory agents that target atherosclerosis-specific immune mechanisms. The CCL2-CCR2 axis has therapeutic potential in human atherosclerosis. However, there are challenges and opportunities related to pharmacological targeting of this pathway that need further investigation and discussion.

EUROPEAN HEART JOURNAL (2022)

Review Peripheral Vascular Disease

Crosstalk between Iron and Arteriosclerosis

Yoshiro Naito et al.

Summary: Iron is an important element for life, but excessive iron can lead to the generation of reactive oxygen species and cellular damage. Iron is implicated in the pathogenesis of arteriosclerosis, although the mechanisms of iron metabolism in arteriosclerosis remain unsolved.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2022)

Review Cardiac & Cardiovascular Systems

Biomarkers of endothelial activation and dysfunction in cardiovascular diseases

Jun Zhang

Summary: Endothelial activation and dysfunction play crucial roles in atherosclerosis, cardiovascular diseases, and cardiorenal syndrome, also being associated with metabolic syndrome and type II diabetes. Identifying specific and sensitive biomarkers has important clinical implications.

REVIEWS IN CARDIOVASCULAR MEDICINE (2022)

Article Cardiac & Cardiovascular Systems

The Role of Iron in Atherosclerosis in Apolipoprotein E Deficient Mice

Juan Ma et al.

Summary: The role of iron in atherosclerosis remains controversial, but this study suggests that an increase in iron content in aortic tissues may contribute to ApoE deficiency-induced atherosclerosis.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

Article Biochemical Research Methods

Cargo loading within ferritin nanocages in preparation for tumor-targeted delivery

Jianlin Zhang et al.

Summary: Ferritins are iron storage proteins that can be used for targeted delivery of anticancer drugs and diagnostic molecules. This study provides detailed procedures for loading different types of cargoes into ferritin nanocages for controlled delivery.

NATURE PROTOCOLS (2021)

Review Cell Biology

Membrane-type I matrix metalloproteinase (MT1-MMP), lipid metabolism, and therapeutic implications

Xiao-Dan Xia et al.

Summary: Lipids play essential roles in physiological functions, and dysregulation of lipid metabolism can lead to various human diseases. The regulation of lipid metabolism involves multiple mechanisms at different levels to maintain homeostasis.

JOURNAL OF MOLECULAR CELL BIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction

Francesca Vinchi et al.

EUROPEAN HEART JOURNAL (2020)

Review Biochemical Research Methods

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

Giovanni C. Forcina et al.

PROTEOMICS (2019)

Review Biochemistry & Molecular Biology

The effects of oxidative stress on the development of atherosclerosis

Mohsen Khosravi et al.

BIOLOGICAL CHEMISTRY (2019)

Review Biochemistry & Molecular Biology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Matthew Dodson et al.

REDOX BIOLOGY (2019)

Article Cell Biology

Metabolic Signature of Dietary Iron Overload in a Mouse Model

Chiara Volani et al.

Article Pharmacology & Pharmacy

Animal models of atherosclerosis

Besa Emini Veseli et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

Review Biochemistry & Molecular Biology

Ferritin, Cellular Iron Storage and Regulation

Paolo Arosio et al.

IUBMB LIFE (2017)

Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

Article Cardiac & Cardiovascular Systems

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

Michael A. Gimbrone et al.

CIRCULATION RESEARCH (2016)

Review Cardiac & Cardiovascular Systems

Vascular oxidative stress, nitric oxide and atherosclerosis

Huige Li et al.

ATHEROSCLEROSIS (2014)

Article Multidisciplinary Sciences

H-ferritin-nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection

Minmin Liang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation

Nobuhiko Harada et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Review Hematology

Ferritin for the clinician

Mary Ann Knovich et al.

BLOOD REVIEWS (2009)

Article Urology & Nephrology

Ferritin Prevents Calcification and Osteoblastic Differentiation of Vascular Smooth Muscle Cells

Abolfazl Zarjou et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)

Article Medicine, Research & Experimental

Overexpression of transferrin receptor and ferritin related to clinical symptoms and destabilization of human carotid plaques

Wei Li et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2008)

Review Immunology

The immune response in atherosclerosis: a double-edged sword

Goran K. Hansson et al.

NATURE REVIEWS IMMUNOLOGY (2006)