期刊
OPHTHALMOLOGY AND THERAPY
卷 -, 期 -, 页码 -出版社
SPRINGER INT PUBL AG
DOI: 10.1007/s40123-023-00816-8
关键词
Central serous chorioretinopathy; Choriocapillaris layer; Choroidal perfusion; Choroidal vascular changes; Optical coherence tomography angiography
This study utilized SS-OCTA to evaluate the long-term changes in the choroidal and choriocapillaris layers in the unaffected eyes of patients with unilateral resolved chronic central serous chorioretinopathy. The results demonstrated significant improvements in choriocapillaris flow deficits during continuous oral eplerenone therapy, with no significant changes in best-corrected visual acuity.
Introduction: The aim of this work is to utilize swept-source optical coherence tomography angiography (SS-OCTA) to assess the long-term changes in the choroidal and choriocapillaris (CC) layers of the fellow unaffected eye of patients with unilateral resolved chronic central serous chorioretinopathy (cCSC) following treatment with continuous oral eplerenone (EPL). Methods: The study included 35 patients with cCSC and subretinal fluid (SRF) in one eye. SSOCTA imaging was performed on the fellow cCSC eyes at baseline, 6 months, and 12 months during eplerenone therapy. CC OCT angiography was analyzed to determine the percentage of choriocapillaris flow deficits (FD%), the number of flow deficits (FDn), and the average area of flow deficits (FDa). Results: The results demonstrated significant changes in CC flow deficits from baseline to follow-up visits. Specifically, there was a significant decrease in FD% from 28.9 +/- 2.2% at baseline to 26.4 +/- 1.9% at 6 months (p = 0.023), and further to 24.9 +/- 1.7% at 12 months (p = 0.001). Additionally, the FD area gradually contracted over the follow-up period (p\ 0.05). Conversely, there was a significant increase in the number of flow deficits compared to baseline (p\ 0.05). No statistically significant changes were observed in best-corrected visual acuity (BCVA) at the follow-up visits (p[ 0.05). Conclusions: The findings of this study demonstrated long-term reperfusion of the choriocapillaris in unaffected fellow cCSC eyes during continuous oral eplerenone therapy. The beneficial effects of eplerenone therapy were observed after 6 months and maintained at 1 year. These results suggest that specific mineralocorticoid receptor (MR) antagonists may be effective in promoting choriocapillaris recovery in the unaffected eyes of patients with cCSC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据