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Review
Chemistry, Physical
Jingjing Gu et al.
Summary: Metabolic reprogramming leads to the preferential utilization of lactate produced by glycolysis as the main energy source by tumor cells, resulting in its accumulation in the tumor microenvironment. Lactate, which was previously considered a waste product, now plays a crucial role in tumor progression and modulation of lactate in the tumor microenvironment has become a potential target for cancer therapy. Nanomedicine offers advantages in drug delivery efficiency and treatment efficacy while minimizing damage to normal tissues, driving the development of lactate modulation-based nanosystems research.
Review
Oncology
Karin E. de Visser et al.
Summary: Cancers consist of tumor cells and various non-cancerous cells in an altered extracellular matrix, forming complex ecosystems. The tumor microenvironment (TME) includes different immune cell types, cancer-associated fibroblasts, endothelial cells, pericytes, and other tissue-resident cells, all of which play critical roles in cancer pathogenesis. The composition and function of the TME can vary depending on the organ, cancer cell features, tumor stage, and patient characteristics. Understanding the interplay between tumor cell-intrinsic, cell-extrinsic, and systemic factors is crucial for developing effective anti-cancer treatments.
Review
Oncology
Emily N. Arner et al.
Summary: Increased glucose metabolism and uptake are characteristic of many tumors and used clinically to diagnose and monitor cancer progression. Cooperation and competition between different cell populations within the tumor microenvironment (TME) drive tumor proliferation, progression, metastasis, and immune evasion. Targeting metabolic heterogeneity within the TME may offer therapeutic opportunities to overcome immune suppression and enhance immunotherapies.
Article
Multidisciplinary Sciences
Xiaotu Ma et al.
Summary: The study presents a genetically modified strain of Escherichia coli that can be manipulated by an alternating magnetic field and used for tumor targeting. The bacteria accumulate in the tumor and convert magnetic signals into heat to trigger the expression of proteins and release anti-CD47 nanobodies, which induces an immune response and provides effective tumor therapy.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Shanshan Jiang et al.
Summary: Lactate oxidase (LOx) has been widely studied for its specific catalysis on l-lactate, which is highly correlated with tumor growth, metastasis, and recurrence. LOx-based biosensors and cancer therapy strategies have been developed, including H2O2-based, O-2-based, pH-sensitive, and electrochemical sensors for cancer diagnosis, as well as lactate-depletion-based metabolic cancer therapy/immunotherapy, hypoxia-activated chemotherapy, H2O2-based chemodynamic therapy, and multimodal synergistic cancer therapy. This review summarizes the recent advances and potential of LOx-based platforms in cancer diagnosis and therapy, and highlights the challenges and potential of LOx-based nanomedicines.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Lu Wang et al.
Summary: The study reports a method of spatiotemporally controllable distribution of combination therapeutics in solid tumors mediated by bacteria, which can reprogram the immune microenvironment of the tumor to optimize antitumor efficacy. Combining the localized heating effect of melanin and the immune activation effect of inhibitors can significantly inhibit tumor growth and prolong survival.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Chi Zhang et al.
Summary: This study introduces smart nano-proteolysis targeting chimeras for photo-metabolic cancer immunotherapy, reprogramming the immunosuppressive tumor microenvironment by utilizing phototherapeutic ablation and cancer-specific protein degradation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biochemistry & Molecular Biology
Leila Kooshki et al.
Summary: Anticancer drugs are limited in their effectiveness due to toxicity, side effects, high costs, and resistance. Cancer's ability to adapt to different signaling pathways and evade immune responses makes it a complex health issue. Recent research highlights the critical role of lactate in cancer development, emphasizing the importance of targeting lactate metabolism/transporters for prevention and management of tumors. Natural secondary metabolites emerge as promising alternative compounds with high efficacy and fewer side effects, targeting lactate-related pathways to combat cancer.
Review
Biotechnology & Applied Microbiology
Aiqin Shi et al.
Summary: This review summarizes the mechanisms, research methods, and successful applications of bacterial adaptive evolution, with a particular emphasis on the contributions of Dr. L. O. Ingram. Microbial adaptive evolution has significant impact on society, both in terms of industrial applications and the evolution, emergence, and control of various pathogens.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Sixuan Wu et al.
Summary: A novel paradigm of starvation therapy is proposed to synergize Zn2+ interference-mediated glycolysis inhibition and Zn2+-activating GLUT1 tumor specific depletion. This therapeutic platform enables ion interference-inductive starvation strategy for effective tumor therapy, showing remarkable tumor growth suppression without systemic toxicity in vivo.
Article
Chemistry, Multidisciplinary
Juanjuan Li et al.
Summary: This study reports a method of decorating bacteria with triple immune nanoactivators to develop tumor-resident living immunotherapeutics. The decorated bacteria show targeted tumor retention and release of drugs, achieving potent antitumor effects. This work provides a versatile platform for cancer immunotherapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Biomedical
Yale Yue et al.
Summary: Outer membrane vesicles (OMVs) produced in the intestine by ingested genetically engineered bacteria, which are fused with tumour antigens, can serve as effective oral tumour vaccines in mice. These OMVs can stimulate dendritic cell maturation, inhibit tumour growth, and generate long-term antitumour immunity.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Wencheng Wu et al.
Summary: A bacterial metabolism-initiated and photothermal-enhanced nanocatalytic therapy strategy has been developed to completely eradicate tumors and induce immunological memory effect.
NANO-MICRO LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Ziliang Dong et al.
Summary: This study presents the preparation of a multifunctional fluorinated calcium carbonate nanoregulator that can reverse tumor immunosuppression and potentiate radiotherapy by chemically modulating tumor hypoxic and acidic microenvironments.
Review
Cell Biology
Kung-Chi Kao et al.
Summary: The metabolically hostile tumour microenvironment can hinder immune cells and impede the effectiveness of immunotherapy. Metabolic communication between cancer cells and immune cells may play a crucial role in determining immune responses. Nutrient-limiting strategies may enhance anti-tumour immune responses.
NATURE CELL BIOLOGY
(2022)
Review
Immunology
Petya Apostolova et al.
Summary: Lactic acid and its conjugate lactate play important roles in the tumor microenvironment, serving as physiological carbon sources for tumors and immune cells, unrelated to immunosuppression. Neutralizing intratumoral acidity while maintaining normal lactate metabolism can enhance anti-tumor immunity.
TRENDS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Rong Sun et al.
Summary: The authors have developed a bacteria-based drug delivery system for the treatment of glioblastoma. This system bypasses the blood-brain barrier and uses photothermal therapy and immune responses to destroy bacteria-infected glioblastoma cells and prolong the survival of mice. The residual bacteria can also be effectively eliminated from the body.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Xiaolu Li et al.
Summary: This article provides a comprehensive review of the role of lactate, clarifying its involvement in diseases and offering references and direction for future research.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Chemistry, Multidisciplinary
Qiutong Jin et al.
Summary: Cancer immunotherapy is a promising therapeutic strategy, but systemic administration of immunotherapeutic agents may lead to severe side effects, necessitating the development of local delivery systems to avoid this issue. Advances in biomaterials, biotechnology, nanomedicine, and engineering have facilitated the development of such systems, which can effectively inhibit cancer recurrence and metastasis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Ziling Zeng et al.
Summary: This study introduces an organic polymer nanoenzyme (SPNK) with near-infrared (NIR) photoactivatable immunotherapeutic effects for photodynamic immunometabolic therapy. By generating singlet oxygen (O-1(2)) upon NIR photoirradiation, SPNK induces immunogenic cell death of cancer and degrades immunosuppressive kynurenine (Kyn), ultimately promoting effector T cell proliferation and infiltration, enhancing systemic antitumor T cell immunity, and inhibiting both primary and distant tumors in living mice.
ADVANCED MATERIALS
(2021)
Article
Multidisciplinary Sciences
Fernando P. Canale et al.
Summary: Engineered bacteria were developed to convert ammonia to l-arginine in tumors, increasing intratumoral l-arginine concentrations, T cell infiltration, and synergistic effects with PD-L1 blocking antibodies in tumor clearance. These results indicate that microbial therapies can enhance immunotherapy efficacy by modulating the tumor microenvironment.
Article
Multidisciplinary Sciences
McLane J. Watson et al.
Summary: T-reg cells exhibit broad heterogeneity in glucose metabolism within normal and transformed tissues, utilizing an alternative metabolic pathway to maintain their suppressive function and proliferation. Glucose uptake is correlated with poorer suppressive function and long-term instability, while high-glucose conditions impair T-reg cell function and stability. Additionally, T-reg cells upregulate pathways involved in the metabolism of lactic acid, with lactate uptake being dispensable for peripheral T-reg cells but required intratumorally for slowed tumor growth and increased response to immunotherapy.
Review
Chemistry, Multidisciplinary
Xuehui Huang et al.
Summary: Bacteria-based cancer immunotherapy has garnered significant attention in the past decade due to its unique mechanism and diverse applications. Bacteria are capable of targeting and colonizing tumor core areas, enhancing immune cell activation in the tumor microenvironment, and promoting specific immune recognition and elimination of tumor cells. The field also benefits from advancements in synthetic biology, allowing for creative immunotherapy paradigms using genetically modified bacteria and the combination of bacteria with nanomaterials for multifunctional cancer immunotherapy.
Article
Chemistry, Multidisciplinary
Baicheng Wei et al.
Summary: A new cancer treatment strategy has been developed, where tumor-associated macrophage polarization therapy combined with ICD induced by low-dose chemotherapy drugs can significantly enhance the efficacy of immunotherapy.
Review
Immunology
Michelangelo Certo et al.
Summary: The microenvironments of cancerous tissues and tissues affected by chronic inflammatory diseases exhibit different immune states but similar metabolic states. Understanding the metabolic signature allows for therapeutic intervention to reset metabolite availability and correct dysregulated immune states.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ke Li et al.
Article
Multidisciplinary Sciences
Xuan Yi et al.
Review
Biochemistry & Molecular Biology
Luigi Ippolito et al.
TRENDS IN BIOCHEMICAL SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Mai Thi-Quynh Duong et al.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2019)
Review
Oncology
Shibin Zhou et al.
NATURE REVIEWS CANCER
(2018)
Article
Chemistry, Multidisciplinary
Rong-Bin Song et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Article
Oncology
Veronica Estrella et al.
Article
Agricultural Engineering
Miriam A. Rosenbaum et al.
BIORESOURCE TECHNOLOGY
(2011)
Review
Oncology
Willem H. Koppenol et al.
NATURE REVIEWS CANCER
(2011)
Review
Multidisciplinary Sciences
Matthew G. Vander Heiden et al.
Review
Genetics & Heredity
HH McAdams et al.
NATURE REVIEWS GENETICS
(2004)
Article
Biotechnology & Applied Microbiology
SH Duncan et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2004)
