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Strategies for Supplying Precursors to Enhance the Production of Secondary Metabolites in Solid-State Fermentation

FERMENTATION-BASEL (2023)

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Article Microbiology

Enhancing bioflavor production by solid-state fermentation using Kluyveromyces marxianus and l-phenylalanine

Priyanka Roy et al.

Summary: This study explores the production of bioflavor compounds, specifically 2-phenylethanol (2-PE) and 2-phenylethyl acetate (2-PEA), using Kluyveromyces marxianus in solid-state fermentation with sweet lemon peel (SLP) and sugarcane bagasse (SB). The quantification of flavor compounds revealed that without any supplements, the concentrations of 2-PE were 0.15 +/- 0.003 mg/g for SLP and 0.14 +/- 0.002 mg/g for SB, while the concentrations of 2-PEA were 0.01 +/- 0.008 mg/g for SLP and 0.02 +/- 0.001 mg/g for SB. The addition of l-phenylalanine (l-phe) showed a 30%-75% enhancement in the production of both 2-PE and 2-PEA. This study suggests that K. marxianus, with the addition of synthetic l-phe, is a promising microbial cell factory for the production of 2-PE and 2-PEA, which can be applied in various industries such as food and pharmaceutical.

JOURNAL OF BASIC MICROBIOLOGY (2023)

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Article Food Science & Technology

Mechanism of Enhancing Pyrazines in Daqu via Inoculating Bacillus licheniformis with Strains Specificity

Qiuxiang Tang et al.

Foods (2023)

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Review Food Science & Technology

Gamma-aminobutyric acid (GABA): a comprehensive review of dietary sources, enrichment technologies, processing effects, health benefits, and its applications

Dianzhi Hou et al.

Summary: Gamma-aminobutyric acid (GABA) is a naturally occurring compound with potential bioactive properties found in plants, microorganisms, animals, and humans. As the main inhibitory neurotransmitter in the central nervous system, GABA has a wide range of bioactivities, making GABA-enriched functional foods highly sought after by consumers. However, natural foods usually have low levels of GABA, and using enrichment technologies to increase GABA content instead of exogenous addition can enhance consumer acceptance among health-conscious individuals.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

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Article Food Science & Technology

Pilot-scale process to produce bio-pigment from Monascus purpureus using broken rice as substrate for solid-state fermentation

Vishu Chaudhary et al.

Summary: This study successfully produced natural red bio-pigment at a pilot-scale by optimizing fermenter type and bio-pigment extraction parameters. The tray-type fermenter outperformed other types for bio-pigment production. The high yield of bio-pigment was extracted with 60% ethanol at 60°C for 80 min. The study also found three color forms of bio-pigment in the extract, namely red, orange, and yellow. The extracted red bio-pigment exhibited sensitivity to UV, sunlight, and pH > 10, but could withstand high temperature and low concentrations of food preservatives.

EUROPEAN FOOD RESEARCH AND TECHNOLOGY (2023)

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Review Biochemistry & Molecular Biology

Multi-Level Optimization and Strategies in Microbial Biotransformation of Nature Products

Dan Qin et al.

Summary: The continuous demand for natural products with pharmacological activities has driven the development of microbial transformation techniques, which enables efficient production of natural products and exploration of new active compounds. It is of great social and economic value to improve and optimize microbial transformation technology for increased yield and activity of transformed products.

MOLECULES (2023)

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Article Biochemistry & Molecular Biology

Notoamide R: A Prominent Diketopiperazine Fermentation Metabolite amongst Others of Aspergillus ochraceus in the Absence of Ochratoxins

Peter Mantle et al.

Summary: Ochratoxin A is a toxic secondary metabolite produced by Aspergillus ochraceus. The identification and prediction of diverse compounds and their biosynthesis pose a challenge. Previous studies in Europe and the USA failed to produce ochratoxin A in certain bean isolates. Analysis of metabolites led to the discovery of notoamide R and its biosynthetic components in a shredded-wheat/shaken-flask fermentation. Further investigations confirmed notoamide R as a prominent metabolite of A. ochraceus. The study also highlighted the importance of intermediary metabolism in secondary metabolite accumulation.

MOLECULES (2023)

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Article Multidisciplinary Sciences

Biotransformation and bioaccessibility of active ingredients from Radix Astragali by Poria cocos during solid-state fermentation and in vitro digestion and antioxidant activity evaluation

Cai-Yun Chen et al.

Summary: The purpose of this study is to improve the biotransformation of Astragaloside IV (AG IV) and its bioaccessibility during in vitro digestion by Poria cocos solid fermenting Radix Astragali. The results showed that the Poria cocos solid fermentation could increase the content of AG IV in Radix Astragali and improve its antioxidant activity, providing new ideas for future development and utilization of Radix Astragali.

SCIENTIFIC REPORTS (2023)

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Article Biotechnology & Applied Microbiology

CRISPR/Cas9-mediated genome editing in vancomycin-producing strain Amycolatopsis keratiniphila

Mengyi Hu et al.

Summary: Amycolatopsis is a valuable source of bioactive natural products, and this study aimed to develop a high-efficiency CRISPR/Cas9-mediated genome editing system in the vancomycin-producing strain A. keratiniphila HCCB10007. The researchers successfully utilized an all-in-one editing plasmid to delete and insert specific genes with 100% efficiency. They also achieved high efficiencies of 81%-97% in deleting large fragments of the ECO-0501 biosynthetic gene cluster by selecting suitable sgRNAs. The deletion of these gene clusters led to a significant improvement in vancomycin production.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2023)

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Review Microbiology

Focus and Insights into the Synthetic Biology-Mediated Chassis of Economically Important Fungi for the Production of High-Value Metabolites

Pragya Tiwari et al.

Summary: Substantial progress has been made in synthetic biology-mediated engineering of biological organisms to produce high-value metabolites. Fungi-based bio-products have gained importance in various industries and applications, making them attractive resources for valuable metabolites. The use of synthetic biology in genetic manipulation of fungal strains has opened new avenues in fungal biotechnology and has the potential to overcome existing limitations. Efforts should be made to address the knowledge gaps and obstacles in fungal biology and engineering for the complete exploitation of valuable fungal strains.

MICROORGANISMS (2023)

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Review Biotechnology & Applied Microbiology

Shikimic acid biosynthesis in microorganisms: Current status and future direction

Qi Sheng et al.

Summary: This review discusses recent advances in the development of SA-producing strains, including genetic modification strategies, metabolic pathway construction, and biosensor-assisted evolution. The development of SA biosensors and dynamic molecular switches, as well as genetic modification strategies and optimization of the fermentation process based on omics technology, can improve the performance of SA-producing strains.

BIOTECHNOLOGY ADVANCES (2023)

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Article Biotechnology & Applied Microbiology

Production of rhamnolipid biosurfactants in solid-state fermentation: process optimization and characterization studies

Shima Dabaghi et al.

Summary: This study identified and optimized the key process parameters for the synthesis of rhamnolipids using soybean meal in solid state fermentation. The optimized conditions resulted in a rhamnolipid production of 19.68 g/kg dry substrate, with low surface tension and good emulsification activity.

BMC BIOTECHNOLOGY (2023)

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Review Green & Sustainable Science & Technology

Solid-State Fermentation for the Recovery of Phenolic Compounds from Agro-Wastes

Nadia D. Cerda-Cejudo et al.

Summary: Polyphenolic compounds are secondary metabolites found in plants, especially in fruits, vegetables, and herbs. Extracting these compounds for various industries, including food, cosmetics, and pharmacology, is a current trend. This review article critically analyzes the extraction of polyphenols using solid-state fermentation, discussing parameters such as substrate, temperature, pH, inoculum, moisture, and water activity. The method of biotechnological extraction using solid-state fermentation can affect the concentration and recovery of polyphenolic compounds, and it has potential in utilizing agricultural waste to create value-added food products.

RESOURCES-BASEL (2023)

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Article Biotechnology & Applied Microbiology

Optimization of fermentation for gamma-aminobutyric acid (GABA) production by yeast Kluyveromyces marxianus C21 in okara (soybean residue)

Lei Zhang et al.

Summary: This study demonstrated the advantages of using okara as a substrate for GABA production through fermentation by K. marxianus C21, and identified the optimal culture conditions. Adding peptone significantly increased GABA production, while glucose and vitamin B6 had no effect on the production.

BIOPROCESS AND BIOSYSTEMS ENGINEERING (2022)

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Article Biochemical Research Methods

High production of jasmonic acid by Lasiodiplodia iranensis using solid-state fermentation: Optimization and understanding

Ziqiang Shen et al.

Summary: By selecting solid substrate and optimizing culture conditions, a maximum JA yield of 5306.38 mg kg(-1) was achieved in a SSF process with Lasiodiplodia iranensis. Models were used to characterize microbial growth and product synthesis, predicting a maximum JA production close to experimental value. LC-MS/MS was used to examine metabolic changes during fermentation, revealing key intermediate metabolites and byproducts of JA biosynthesis.

BIOTECHNOLOGY JOURNAL (2022)

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Review Biochemistry & Molecular Biology

Anticancer Activities of Marine-Derived Phenolic Compounds and Their Derivatives

Dario Matulja et al.

Summary: Marine organisms produce diverse secondary metabolites with various biological activities, including anticancer effects. Marine phenolic compounds and their derivatives have been studied for their potential anticancer activity. These compounds inhibit cancer cell proliferation or migration at sub-micromolar or nanomolar concentrations. They exert their anticancer effects through different mechanisms, such as apoptosis induction or inhibition of cell migration. Phenolic compounds like phlorotannins and bromophenols have been extensively studied and recognized for their protective effects against UVB or gamma radiation-induced skin damage. Phenolic metabolites can be classified into six main classes.

MOLECULES (2022)

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Editorial Material Microbiology

Microbial Secondary Metabolism and Biotechnology

Mireille Fouillaud et al.

Summary: Scientific research has revealed the incredible diversity and significance of the microbial world, offering potential solutions to important questions about human and animal health, as well as society's needs for medicine, pharmacology, nutrition, and well-being.

MICROORGANISMS (2022)

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Article Biochemistry & Molecular Biology

Identification of New Natural Sources of Flavour and Aroma Metabolites from Solid-State Fermentation of Agro-Industrial By-Products

Melodie A. Lindsay et al.

Summary: Increasing consumer demand for natural flavours and fragrances has led to higher prices and increased pressure on natural resources. Research into alternative supplies of these valuable compounds through solid-state fermentation processes and the utilization of agro-industrial by-products has resulted in high yields and high-value natural flavours and aromas.

METABOLITES (2022)

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Article Biotechnology & Applied Microbiology

Avermectin B1a production in Streptomyces avermitilis is enhanced by engineering aveC and precursor supply genes

Yi Hao et al.

Summary: This study successfully increased the production of avermectins B1a, a potent anthelmintic agent, in Streptomyces avermitilis by combining multiple strategies.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2022)

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Article Agricultural Engineering

Secondary metabolites produced by solid-state fermentation of a neotropical Aspergillus flavus strain confer anti-mosquito activity with long shelf-life

Mellanie K. C. Felix et al.

Summary: Fungal metabolites obtained from solid-state fermentation of maize substrate showed potential as alternative tools for controlling Aedes aegypti mosquito larvae. The study found that these metabolites exhibited mosquitocidal activities and maintained efficacy even after a long storage period.

INDUSTRIAL CROPS AND PRODUCTS (2022)

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Article Biotechnology & Applied Microbiology

A systematic study of the production of Monacolin K by solid state fermentation of Monascus ruber

Xiuhe Liu et al.

Summary: This study investigated the key factors for Monacolin K production through solid-state fermentation by Monascus ruber. The results showed that initial moisture and bran content were crucial for nutrient and oxygen transport. Under optimal conditions, the Monacolin K yield was higher compared to commercially available red yeast rice.

AMB EXPRESS (2022)

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Article Mycology

Improvement of beauvericin production by Fusarium oxysporum AB2 under solid-state fermentation using an optimised liquid medium and co-cultures

J. Norberto Vasquez-Bonilla et al.

Summary: This study compared the production of beauvericin (BEA) by Fusarium oxysporum AB2 in liquid medium and on solid medium. It was found that the production was higher on solid medium, and it further increased with concentrated medium. Additionally, the production of BEA could be increased through mixed culture.

MYCOTOXIN RESEARCH (2022)

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Review Food Science & Technology

Enrichment of gamma-aminobutyric acid in foods: From conventional methods to innovative technologies

Yu Sun et al.

Summary: This paper comprehensively reviews both conventional and innovative enrichment methods for GABA, discussing their advantages, limitations, associated mechanisms, and applicable foods. It also summarizes the functions of GABA, factors influencing its enrichment, related patents, and functional foods rich in GABA. The mechanisms of GABA enrichment are mainly related to changes in cell microstructure, modulation of H+ and Ca2+ concentration and enzyme configuration, and regulation of gene and protein expression. This review provides important information for the production of GABA-enriched foods.

FOOD RESEARCH INTERNATIONAL (2022)

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Review Biochemistry & Molecular Biology

Metabolic Engineering of Shikimic Acid Biosynthesis Pathway for the Production of Shikimic Acid and Its Branched Products in Microorganisms: Advances and Prospects

Sijia Wu et al.

Summary: The shikimate pathway is essential for synthesizing aromatic compounds and its intermediate products have promising properties in various fields, particularly the pharmaceutical industry. Through metabolic engineering, the shikimate pathway can be modified to accumulate a variety of target products.

MOLECULES (2022)

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Article Agriculture, Dairy & Animal Science

Bioprocessing of Two Crop Residues for Animal Feeding into a High-Yield Lovastatin Feed Supplement

Amaury Abrego-Garcia et al.

Summary: Lovastatin is a fungal secondary metabolite that can reduce rumen methane production. This study evaluated lovastatin production from selected crop residues and A. terreus strains through solid-state fermentation, with the aim of using the post-fermented residues as feed supplements for ruminants. The highest lovastatin yield was obtained from oat straw fermented by A. terreus CDBB H-194. GC-MS analysis identified potential compounds in the residues that could negatively affect ruminal bacteria and fungi.

ANIMALS (2022)

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Article Biotechnology & Applied Microbiology

Biotransformation of Agricultural By-Products into Biovanillin through Solid-State Fermentation (SSF) and Optimization of Different Parameters Using Response Surface Methodology (RSM)

Tahir Mehmood et al.

Summary: This study examined the transformation of ferulic acid, a natural precursor for biovanillin synthesis, into biovanillin through solid-state fermentation using various agricultural lignocellulosic by-products. The optimal physicochemical parameters for biovanillin production were determined using response surface methodology, and sugarcane bagasse was identified as a cost-effective substrate choice for large-scale biovanillin production.

FERMENTATION-BASEL (2022)

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Article Biotechnology & Applied Microbiology

Valorization of Fruit Peels into Biovanillin and Statistical Optimization of Process Using Enterobacter hormaechei through Solid-State Fermentation

Tahir Mehmood et al.

Summary: This study demonstrates the production of biovanillin via solid-state fermentation using different ferulic acid-rich fruit peels as substrates. The maximum biovanillin yield was achieved using pomegranate peels, with optimized parameters including moisture content, inoculum size, pH, and temperature. The results indicate that microbial conversion of ferulic acid-rich fruit peels offers a cost-effective approach for industrial biovanillin production.

FERMENTATION-BASEL (2022)

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Article Environmental Sciences

Production of Gallic Acid Under Solid-State Fermentation by Utilizing Waste from Food Processing Industries

Shagufta Saeed et al.

Summary: This study evaluated the potential of using various fruit processing industry wastes to produce gallic acid via solid state fermentation with Aspergillus niger. The results showed that black plum seed powder yielded the highest amount of gallic acid, and supplementation of carbon source increased the synthesis of gallic acid. The solid state fermentation protocol developed in this study proved to be a cost-effective method for industrial production of gallic acid.

WASTE AND BIOMASS VALORIZATION (2021)

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Article Food Science & Technology

Enhanced production of γ-aminobutyric acid (GABA) using Lactobacillus plantarum EJ2014 with simple medium composition

Su Jeong Park et al.

Summary: In this study, a synthetic medium was used to efficiently produce high titer of GABA using Lactobacillus plantarum. The optimized medium composition resulted in the highest GABA production compared to previous studies. The use of yeast extract as a secondary substrate source also contributed to achieving a yield exceeding the theoretical maximum.

LWT-FOOD SCIENCE AND TECHNOLOGY (2021)

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Review Agricultural Engineering

Recent developments on solid-state fermentation for production of microbial secondary metabolites: Challenges and solutions

Vinod Kumar et al.

Summary: Microbial secondary metabolites play a major role in various industries and are produced during fermentation process. Solid-state fermentation provides a natural environment for microorganisms to adapt. Advanced techniques in bioprocessing have been developed to improve microbial SMs production.

BIORESOURCE TECHNOLOGY (2021)

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Article Microbiology

Production and statistical optimization of Paromomycin by Streptomyces rimosus NRRL 2455 in solid state fermentation

Ghadir S. El-Housseiny et al.

Summary: This study introduced a strategy for paromomycin production through solid-state fermentation using Streptomyces rimosus subsp. paromomycinus NRRL 2455. By selecting corn bran as the substrate and optimizing environmental conditions, a higher paromomycin yield was obtained compared to submerged liquid fermentation. Solid state fermentation not only resulted in comparable paromomycin concentrations, but also reduced costs, energy consumption, and waste water discharge.

BMC MICROBIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

The eukaryotic MEP-pathway genes are evolutionarily conserved and originated from Chlaymidia and cyanobacteria

Liping Zeng et al.

Summary: This study analyzes the evolutionary history of MEP-pathway genes, showing their polyphyletic origin and restricted conservation. It also highlights the indispensable function of individual enzymes in the MEP pathway beyond isoprenoid production, supported by their high expression levels and distinct phenotypic variations in plants with reduced expression levels.

BMC GENOMICS (2021)

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Article Engineering, Environmental

Valorization of agro-industrial wastes by producing 2-phenylethanol via solid-state fermentation: Influence of substrate selection on the process

Oscar Martinez-Avila et al.

Summary: 2-phenylethanol (2-PE), a compound with rose-like odor and antibacterial properties, can be produced using agro-industrial wastes. This study evaluated nine different wastes as potential substrates for 2-PE production and identified red apple pomace as the most effective waste. It was found that the reducing sugars content, air-filled porosity, and availability of L-phenylalanine in the substrates were key parameters influencing microbial activity and 2-PE production.

WASTE MANAGEMENT (2021)

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Article Biochemical Research Methods

Strategy for Producing the High-Quality Glycopeptide Antibiotic A82846B in Amycolatopsis orientalis Based on the CRISPR-Cas12a System

Hui Qian et al.

Summary: By constructing the synthetic pathway of A82846B, we established a highly efficient CRISPR-Cas12a system, optimized conjugation conditions, and screened regulatory elements in Amycolatopsis orientalis, which is difficult to genetically manipulate. The glycosyltransferases and glycosyl synthesis modules in the vancomycin gene cluster were replaced with corresponding modules in the A82846B cluster, leading to successful production of A82846B. Furthermore, the titer of A82846B was increased by 80% through expression of the pathway-specific regulatory strR, showcasing potential for redesigning natural products to combat antibiotic resistance.

ACS SYNTHETIC BIOLOGY (2021)

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Article Engineering, Chemical

Zinc ion addition to grain media enhanced hispidin production during solid-state fermentation of Phellinus linteus

Chiu-Yeh Wu et al.

Summary: This study shows that the addition of Zn2+ ions to the grain media can enhance the production of hispidin by P. linteus 03, resulting in significantly higher yield and productivity.

JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS (2021)

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Review Biotechnology & Applied Microbiology

Exploiting endophytic microbes as micro-factories for plant secondary metabolite production

Sushma Mishra et al.

Summary: Plant secondary metabolites have potential applications in various industries, but their direct isolation from plants may lead to over-harvesting and loss of biodiversity. Endophytic microbes have the ability to produce metabolites similar to those of their host plants, providing a sustainable and commercially valuable resource.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2021)

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Shanshan Li et al.

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O. Renteria-Martinez et al.

Summary: The yeast Pichia fermentans ITD-00165 shows high potential for producing isoamyl acetate, with well-controlled aeration and agitation speed enhancing production, but excessive aeration may have a negative impact. Additionally, concomitant ethanol production is found to negatively affect aroma production.

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Optimization and scale-up of the production of rhamnolipid by Pseudomonas aeruginosa in solid-state fermentation using high-density polyurethane foam as an inert support

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Effects of Chinese medicines on monacolin K production and related genes transcription of Monascus ruber in red mold rice fermentation

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New knowledge about the biosynthesis of lovastatin and its production by fermentation ofAspergillus terreus

Javier Barrios-Gonzalez et al.

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Biosurfactants: The Green Generation of Speciality Chemicals and Potential Production Using Solid-State Fermentation (SSF) Technology

Ibrahim M. Banat et al.

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Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review

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Coupling energy-production processes: The use of residues from bioethanol production to improve the anaerobic digestion of corn stover

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High yield of tetramethylpyrazine in functional Fuqu using bacillus amyloliquefaciens

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Using millet as substrate for efficient production of monacolin K by solid-state fermentation of &ITMonascus ruber&IT

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Production and characterization of sophorolipids from stearic acid by solid-state fermentation, a cleaner alternative to chemical surfactants

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Synthesis of Heterologous Mevalonic Acid Pathway Enzymes in Clostridium ljungdahlii for the Conversion of Fructose and of Syngas to Mevalonate and Isoprene

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Precursor Supply Strategy for Tetramethylpyrazine Production by Bacillus Subtilis on Solid-State Fermentation of Wheat Bran

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Semi-solid-state fermentation: A promising alternative for neomycin production by the actinomycete Streptomyces fradiae

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Compactin Production Studies Using Penicillium brevicompactum Under Solid-State Fermentation Conditions

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High lovastatin production by Aspergillus terreus in solid-state fermentation on polyurethane foam: An artificial inert support

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A Novel Medium for the Enhanced Production of Cyclosporin A by Tolypocladium inflatum MTCC 557 Using Solid State Fermentation

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High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain

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Influence of pH regulation and nutrient content on cephalosporin C production in solid-state fermentation by Acremonium chrysogenum C10

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Current industrial practice in solid state fermentations for secondary metabolite production: the Biocon India experience

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Modelling Gibberella fujikuroi growth and GA3 production in solid-state fermentation

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Optimization of bagasse, nutrients and initial moisture ratios on the yield of penicillin in solid-state fermentation

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Respiration studies of penicillin solid-state fermentation

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