Proline fuels ILC3s to maintain gut health

Group 3 innate lymphoid cells (ILC3s) maintain intestinal barrier integrity and nutrient absorption via IL-22; however, little is known about how these immune cells fuel effector function. Wu et al. now report that uptake of dietary proline acts as a critical metabolic modulator of the ILC3 transcriptome and cytokine production to maintain gut health.

Automated summary

This study reveals the importance of dietary proline in maintaining gut health, as it modulates the metabolism and cytokine production of group 3 innate lymphoid cells (ILC3s) responsible for intestinal barrier integrity.