期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 23, 期 2, 页码 103-109出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3163
关键词
-
资金
- US National Institutes of Health [R01GM108648]
The replication-stress response enables the DNA replication machinery to overcome DNA lesions or intrinsic replication-fork obstacles, and it is essential to ensure faithful transmission of genetic information to daughter cells. Multiple replication stress-response pathways have been identified in recent years, thus raising questions about the specific and possibly redundant functions of these pathways. Here, we review the emerging mechanisms of the replication-stress response in mammalian cells and consider how they may influence the dynamics of the core DNA replication complex.
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