期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 23, 期 7, 页码 624-630出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3244
关键词
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资金
- Caltech startup funds, an Albert Wyrick V Scholar Award from the V Foundation for Cancer Research
- Edward Mallinckrodt Jr. Foundation
- Sidney Kimmel Foundation for Cancer Research
- Camille & Henry Dreyfus Foundation
- National Institutes of Health (NIH) [R01-GM111461, R01-GM117360]
- National Institute on Aging (NIA) [R21-AG047433]
- EMBL
- European Research Council [309271-NPCAtlas]
Elucidating the structure of the nuclear pore complex (NPC) is a prerequisite for understanding the molecular mechanism of nucleocytoplasmic transport. However, owing to its sheer size and flexibility, the NPC is unapproachable by classical structure determination techniques and requires a joint effort of complementary methods. Whereas bottom-up approaches rely on biochemical interaction studies and crystal-structure determination of NPC components, top-down approaches attempt to determine the structure of the intact NPC in situ. Recently, both approaches have converged, thereby bridging the resolution gap from the higher-order scaffold structure to near-atomic resolution and opening the door for structure guided experimental interrogations of NPC function.
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