Nanomicelle-Based Redox-Responsive Dual-Prodrug for Synergistic Breast Cancer Chemo-Immunotherapy

Article Nanoscience & Nanotechnology

Simultaneous Knockdown of Immune Suppressive Markers by Tumor Microenvironment-Responsive Multifaceted Prodrug Nanomedicine

Liuwei Zhang et al.

Summary: Targeted therapy, inhibition of immune suppressive molecules, and the use of chemotherapy drugs can improve anti-tumor outcomes.

ACS APPLIED MATERIALS & INTERFACES (2023)

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Article Pharmacology & Pharmacy

Charge reversal yolk-shell liposome co-loaded JQ1 and doxorubicin with high drug loading and optimal ratio for synergistically enhanced tumor chemo-immunotherapy via blockade PD-L1 pathway

Dechun Liu et al.

Summary: Antitumor immunotherapy harnesses the immune system to identify and kill malignant tumors, but is hindered by the immunosuppressive microenvironment and poor immunogenicity. Researchers developed a charge reversal yolk-shell liposome that co-loaded JQ1 and doxorubicin (DOX) to enhance hydrophobic drug loading and stability, and blockade the PD-L1 pathway to strengthen chemo-immunotherapy. In vivo results demonstrated the effectiveness of this strategy in tumor-bearing mice models.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

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Article Chemistry, Physical

pH-responsive organic/inorganic hybrid nanocolloids for transcellular delivery of ribonucleolytic payloads toward targeted anti-glioma therapy

Hongyan Cui et al.

Summary: Proteins have inherent limitations in their clinical applications due to their cell-impermeable nature, but researchers have developed intelligent pH-responsive pro-RNase delivery nanocolloids to overcome this obstacle. The nanocolloids actively accumulate in glioma and exhibit efficient endolysosomal escape, allowing for translocation into the cytosol and RNA degradation for apoptosis of affected cells. This versatile platform shows potent anti-tumor efficacy and has the potential to be used in precision intervention of intractable diseases.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2023)

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Article Engineering, Biomedical

Enzyme-triggered deep tumor penetration of a dual-drug nanomedicine enables an enhanced cancer combination therapy

Lei Gu et al.

Summary: Emerging nanomedicines can eliminate cancer cells by promoting excessive intracellular reactive oxygen species (ROS) generation. However, tumor heterogeneity and poor penetration of nanomedicines often result in varying levels of ROS production, where low levels of ROS can actually promote tumor cell growth, reducing the effectiveness of these nanomedicines. In this study, a novel amphiphilic and block polymer-dendron conjugate-derived nanomedicine (GFLG-DP/Lap NPs) was developed, incorporating a photosensitizer (Ppa) for ROS therapy and Lapatinib (Lap) for molecular targeted therapy. By combining ROS therapy with Lap, the synergistic effect effectively kills cancer cells, even in deep tumor regions.

BIOACTIVE MATERIALS (2023)

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Article Pharmacology & Pharmacy

GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine

Lei Luo et al.

Summary: In this study, a redox-responsive polymeric prodrug was synthesized by RAFT polymerization for precise delivery of combinational therapeutic agents. The prodrug exhibited a chemo-photodynamic therapeutic effect to kill breast cancer cells and showed a remarkable in vivo anticancer efficacy. The findings suggest that the redox-responsive polymeric prodrug has great potential as an anti-cancer agent for combinational therapy.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Pharmacology & Pharmacy

Impact of the amount of PEG on prodrug nanoassemblies for efficient cancer therapy

Yaqiao Li et al.

Summary: This study investigates the impact of polyethylene glycol (PEG) on prodrug self-assembled nanoparticles (prodrug-SANPs). The findings demonstrate that an appropriate amount of PEG can enhance the self-assemble stability and pharmacokinetic behavior of prodrug-SANPs, leading to excellent antitumor efficacy.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

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Article Nanoscience & Nanotechnology

Charge-Reversible Pro-Ribonuclease Enveloped in Virus-like Synthetic Nanocapsules for Systemic Treatment of Intractable Glioma

Hongyan Cui et al.

Summary: This study utilizes tailored chemistries to create artificial virus-like delivery vehicles that mimic viral transportation pathways. Through specific reactions and molecular design, these vehicles can release active protein payloads when targeting tumor cells, potentially providing a novel approach for cancer treatment.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Biotechnology & Applied Microbiology

Injectable pH-responsive hydrogel for combinatorial chemoimmunotherapy tailored to the tumor microenvironment

Jun Gu et al.

Summary: A therapeutic silk-chitosan composite scaffold was fabricated to control the release of chemotherapeutic drugs and inhibitors, aiming to enhance the efficacy of immunotherapy and minimize adverse effects.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Genetically Engineered Hematopoietic Stem Cells Deliver TGF-β Inhibitor to Enhance Bone Metastases Immunotherapy

Beilei Wang et al.

Summary: This study demonstrates the use of genetically engineered hematopoietic stem cells (HSCs) expressing PD1 to deliver TGF-beta inhibitor to bone metastases. This strategy changes the immune microenvironment of the bone marrow and enhances anti-tumor immunity, showing great promise for the treatment of bone metastases.

ADVANCED SCIENCE (2022)

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Article Agriculture, Multidisciplinary

Synthetic Nanoscale RNAi Constructs as Pesticides for the Control of Locust Migratoria

Qiong Lu et al.

Summary: In this study, a block copolymer was designed to improve the efficiency of RNAi in insects. The material protected dsRNA from degradation and facilitated its movement through physiological barriers. Encapsulation of dsRNA resulted in down-regulation of insect genes and the development of abnormal phenotypes. These dsRNA constructs show potential as a versatile pesticide against destructive insects and insects resistant to conventional pesticides.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Protein Binding Nanoparticles as an Integrated Platform for Cancer Diagnosis and Treatment

Xuemei Wang et al.

Summary: Smart nanomaterials offer a new approach to improve the safety and effectiveness of combined anti-cancer immunotherapy by delivering multiple proteins to cells, enabling imaging, and combining various treatment methods.

ADVANCED SCIENCE (2022)

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Article Pharmacology & Pharmacy

Lipid nanoparticle-mediated CRISPR/Cas9 gene editing and metabolic engineering for anticancer immunotherapy

Hyemin Ju et al.

Summary: This study developed a cationic lipid nanoparticle formulation for LDHA gene editing and highlighted the potential of activating immune responses in the tumor microenvironment.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

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Article Multidisciplinary Sciences

Polypeptide nanoformulation-induced immunogenic cell death and remission of immunosuppression for enhanced chemoimmunotherapy

Xiangru Feng et al.

Summary: Conventional chemotherapeutics induce immunogenic cell death in tumor cells, but are limited by the presence of immunosuppressive lymphocytes in the tumor microenvironment. Combining low-dose DOX with 1MT to overcome immune suppression, delivered via a reduction-responsive polypeptide nanogel, effectively suppressed tumor growth and enhanced CD8(+) T cell frequency. The chemoimmunotherapy strategy shows great potential in clinical cancer therapy.

SCIENCE BULLETIN (2021)

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Review Nanoscience & Nanotechnology

Recent advances in development of dendriticpolymer-basednanomedicines for cancer diagnosis

Haonan Li et al.

Summary: Dendritic polymers with highly branched three-dimensional architectures and low viscosity have great potential in various biomedical applications. Despite most review articles focusing on drug or gene delivery, there is still a lack of discussion on their function as cancer diagnosis agents.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Anti-PD-L1 mediating tumor-targeted codelivery of liposomal irinotecan/JQ1 for chemo-immunotherapy

Zhi-di He et al.

Summary: The development of a PD-L1-targeting immune liposome for co-delivering irinotecan and JQ1 enhances antitumor immunity in colorectal cancer by inducing immunogenic cell death and interfering in the immunosuppressive pathway, leading to increased intratumoral drug accumulation, DC maturation, adaptive immune responses, and remodeled tumor immune microenvironment. This chemo-immunotherapy strategy effectively activates the host immune system and inhibits tumor growth.

ACTA PHARMACOLOGICA SINICA (2021)

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Article Nanoscience & Nanotechnology

Spatiotemporal Concurrent Liberation of Cytotoxins from Dual-Prodrug Nanomedicine for Synergistic Antitumor Therapy

Liuwei Zhang et al.

Summary: The study developed dual prodrug nanomedicine that can sequentially respond to intracellular chemical potentials, overcoming predefined biological barriers and facilitating intracellular trafficking. The nanomedicine showed significant cytotoxic potencies due to its ability to be activated and liberated in the cytoplasm, leading to potent tumor suppression efficacy in treating solid breast adenocarcinoma.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Overcoming immune resistance by sequential prodrug nanovesicles for promoting chemoimmunotherapy of cancer

Fengqi Zhou et al.

Summary: The study introduces a sequential prodrug nanovesicle designed to enhance drug delivery to tumor tissues and reduce immunological resistance of tumor cells. The nanovesicles show promising results in inhibiting tumor growth and suppressing metastasis in mouse models, providing a new approach for chemoimmunotherapy of cancers by overcoming immune evasion through the IFN-gamma-BRD4-PD-L1 axis.

NANO TODAY (2021)

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Article Chemistry, Multidisciplinary

Self-Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy

Xiuli Zheng et al.

Summary: The self-stabilized supramolecular assembly (SSA) constructed from a PEGylated dendritic peptide conjugate shows potential for enhancing tumor retention and therapy. The concentration-dependent supramolecular self-assembly of PDPP forms various SSAs with different sizes and stability, leading to significantly improved in vivo photodynamic therapeutic efficiency.

ADVANCED SCIENCE (2021)

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Article Oncology

A cellular census of human peripheral immune cells identifies novel cell states in lung diseases

Dongli Song et al.

Summary: Increasing evidence indicates the central role of the immune system in lung diseases, providing opportunities for immunotherapy. Studying immunological alterations between lung diseases through proteomic and transcriptomic profiles offers new insights into immune cell function and interactions.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Cell Biology

Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming

Samantha M. Morrissey et al.

Summary: The study reveals that tumor-derived exosomes can polarize macrophages towards an immunosuppressive phenotype through NF-kB and glycolytic reprogramming, and are associated with lactate, GLUT-1, and YKT6 factors, further promoting tumor metastasis.

CELL METABOLISM (2021)

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Review Biochemistry & Molecular Biology

The role of lncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy

Wenxiao Jiang et al.

Summary: The focus of the study is on understanding the regulatory roles of long noncoding RNAs and circular RNAs in the PD-1/PD-L1 pathway, in hopes of driving more precise and effective cancer immune checkpoint therapies.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

Co-targeting BET bromodomain BRD4 and RAC1 suppresses growth, stemness and tumorigenesis by disrupting the c-MYC-G9a-FTH1axis and downregulating HDAC1 in molecular subtypes of breast cancer

Amjad Ali et al.

Summary: Combined inhibition of BRD4-RAC1 signaling pathways shows promising antitumor effects in different molecular subtypes of breast cancer, suppressing cell growth, migration, and stem cell expansion while inducing autophagy and cellular senescence. Co-targeting RAC1-BRD4 presents a novel therapeutic approach by disrupting key axis and epigenetic regulation in breast tumorigenesis.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Cell Biology