Multi-Criterial Model for Weighting Biological Risk Factors in Multiple Sclerosis: Clinical and Health Insurance Implications

Review Biochemistry & Molecular Biology

GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review

Roberto De Masi et al.

Summary: Glycans are an important component of living matter with metabolic, structural, and modulatory functions. Abnormal glycans can lead to protein misfolding and cyst formation in certain diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Cardiac & Cardiovascular Systems

Trends in cardiovascular diseases burden and vascular risk factors in Italy: The Global Burden of Disease study 1990-2017

Paolo A. Cortesi et al.

Summary: Our study shows a decline in cardiovascular mortality and disability-adjusted life years, reflecting the success in reducing disability, premature death, and early incidence of cardiovascular diseases. However, the burden of cardiovascular diseases remains high, with modifiable risk factors such as high blood pressure, dietary risks, high cholesterol, and impaired kidney function contributing to more than 80% of the burden. Collaboration and coordination among all stakeholders of the Italian National Health System are required to further reduce this burden.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2021)

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Review Health Care Sciences & Services

Impacts of chronic disease prevention programs implemented by private health insurers: a systematic review

Sithara Wanni Arachchige Dona et al.

Summary: This study investigated the impacts of chronic disease prevention interventions implemented by private health insurers (PHI) in Australia and internationally. The main types of interventions implemented by PHIs were financial incentives, health coaching, wellness programs, and group medical appointments. The study found that PHI interventions of longer duration (at least 2 years) were more beneficial and outcomes were more sustained.

BMC HEALTH SERVICES RESEARCH (2021)

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Article Chemistry, Medicinal

The Age-Related Efficacy of Dimethyl Fumarate and Natalizumab in the Real-World Management of Multiple Sclerosis

Roberto De Masi et al.

Summary: The study revealed that age plays a significant role in disability and treatment response in multiple sclerosis management. Patients treated with natalizumab were more likely to maintain a lower EDSS score and less likely to reach a higher score compared to those treated with dimethyl fumarate, with age being a key factor in these outcomes.

PHARMACEUTICALS (2021)

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Article Health Care Sciences & Services

What Can We Learn from Sex Differences in MS?

Patricia K. Coyle

Summary: Multiple sclerosis is a major central nervous system disease that predominantly affects young adults, with females being more susceptible than males. Research has shown that sex-based differences influence various aspects of multiple sclerosis, leading to new insights in understanding, management, and treatment of the disease.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Article Chemistry, Medicinal

GANAB as a Novel Biomarker in Multiple Sclerosis: Correlation with Neuroinflammation and IFI35

Roberto De Masi et al.

Summary: The study found that GANAB expression levels were associated with disease activity and treatment response in multiple sclerosis patients, showing potential as a predictive biomarker of neuroinflammation.

PHARMACEUTICALS (2021)

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Article Biology

IFP35 Is a Relevant Factor in Innate Immunity, Multiple Sclerosis, and Other Chronic Inflammatory Diseases: A Review

Roberto De Masi et al.

Summary: IFP35 is a highly conserved protein with unknown biological function, playing a role in immune response and disease development, especially in demyelinating diseases of the central nervous system.

BIOLOGY-BASEL (2021)

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Article Cardiac & Cardiovascular Systems

Cardiovascular disease burden: Italian and global perspectives

Andrea Saglietto et al.

Summary: The prevalence of cardiovascular disease in Italy is nearly double the global prevalence, with similar age-standardized estimates. However, mortality and morbidity rates from cardiovascular disease in Italy are lower than global estimates. Ischemic heart disease is the most significant burden of cardiovascular disease in Italy.

MINERVA CARDIOLOGY AND ANGIOLOGY (2021)

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Article Medicine, Research & Experimental

IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis

Roberto De Masi et al.

LIFE SCIENCES (2020)

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Article Multidisciplinary Sciences

Serum neurofilament light chain predicts long term clinical outcomes in multiple sclerosis

Simon Thebault et al.

SCIENTIFIC REPORTS (2020)

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Article Endocrinology & Metabolism

Sex differences in brain atrophy in multiple sclerosis

Rhonda R. Voskuhl et al.

BIOLOGY OF SEX DIFFERENCES (2020)

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Review Clinical Neurology

Comorbidity in Multiple Sclerosis

Melinda Magyari et al.

FRONTIERS IN NEUROLOGY (2020)

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Article Clinical Neurology

Aging and efficacy of disease-modifying therapies in multiple sclerosis: a meta-analysis of clinical trials

Yinan Zhang et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2020)

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Article Medicine, Research & Experimental

Lifestyle and Environmental Factors in Multiple Sclerosis

Lars Alfredsson et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2019)

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Review Clinical Neurology

Environmental and genetic risk factors for MS: an integrated review

Emmanuelle Waubant et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2019)

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Article Clinical Neurology

Male factor infertility and risk of multiple sclerosis: A register-based cohort study

Clara Helene Glazer et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

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Review Clinical Neurology

Diet, Gut Microbiota, and Vitamins D plus A in Multiple Sclerosis

Paolo Riccio et al.

NEUROTHERAPEUTICS (2018)

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Article Clinical Neurology

Male factor infertility and risk of multiple sclerosis: A register-based cohort study

Clara Helene Glazer et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

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Article Clinical Neurology

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

Alan J. Thompson et al.

LANCET NEUROLOGY (2018)

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Article Clinical Neurology

The role of testosterone in MS risk and course

Tanuja Chitnis

MULTIPLE SCLEROSIS JOURNAL (2018)

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Review Medicine, General & Internal

Multiple Sclerosis

Daniel S. Reich et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Clinical Neurology

The role of testosterone in MS risk and course

Tanuja Chitnis

MULTIPLE SCLEROSIS JOURNAL (2018)

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Review Public, Environmental & Occupational Health

Data resource profile: the National Health Insurance Research Database (NHIRD)

Liang-Yu Lin et al.

EPIDEMIOLOGY AND HEALTH (2018)

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Review Neurosciences

The Importance of Studying Sex Differences in Disease: The Example of Multiple Sclerosis

Lisa C. Golden et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2017)

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Article Clinical Neurology

Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS

Milena A. Gianfrancesco et al.

NEUROLOGY (2017)

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Review Psychiatry

Vitamin-D Deficiency As a Potential Environmental Risk Factor in Multiple Sclerosis, Schizophrenia, and Autism

Eva Kocovska et al.

FRONTIERS IN PSYCHIATRY (2017)

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Review Cell Biology

Role of immune cells in obesity induced low grade inflammation and insulin resistance

Ambreen Asghar et al.

CELLULAR IMMUNOLOGY (2017)

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Article Medicine, General & Internal

Obesity and inflammation: the linking mechanism and the complications

Mohammed S. Ellulu et al.

ARCHIVES OF MEDICAL SCIENCE (2017)

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Article Clinical Neurology

Sex differences in comorbidity at diagnosis of multiple sclerosis A population-based study

Ruth Ann Marrie et al.

NEUROLOGY (2016)

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Review Clinical Neurology

Multiple sclerosis genetics

Stephen Sawcer et al.

LANCET NEUROLOGY (2014)

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Article Clinical Neurology

Asymptomatic MS

Aksel Siva

CLINICAL NEUROLOGY AND NEUROSURGERY (2013)

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Review Clinical Neurology

Sex and gender issues in multiple sclerosis

Hanne F. Harbo et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2013)

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Review Clinical Neurology

Neurofilaments as biomarkers in multiple sclerosis

Charlotte E. Teunissen et al.

MULTIPLE SCLEROSIS JOURNAL (2012)

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Review Clinical Neurology

Prevention and treatment of MS: studying the effects of vitamin D

Kassandra L. Munger et al.

MULTIPLE SCLEROSIS JOURNAL (2011)

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Article Clinical Neurology

Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis

R. A. Marrie et al.

NEUROLOGY (2010)

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Article Clinical Neurology

Gender-related differences in MS: a study of conventional and nonconventional MRI measures

R. Antulov et al.

MULTIPLE SCLEROSIS JOURNAL (2009)

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Article Medicine, General & Internal

Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis

Kassandra L. Munger et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)

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Review Medicine, General & Internal

Multiple sclerosis

A Compston et al.

LANCET (2002)

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Article Clinical Neurology

Age-related disability in multiple sclerosis

M Trojano et al.

ANNALS OF NEUROLOGY (2002)

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Article Clinical Neurology

The age-range of risk of developing multiple sclerosis - Evidence from a migrant population in Australia

SR Hammond et al.

BRAIN (2000)

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Article Nutrition & Dietetics

Decreased bioavailability of vitamin D in obesity

J Wortsman et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2000)

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Multi-Criterial Model for Weighting Biological Risk Factors in Multiple Sclerosis: Clinical and Health Insurance Implications

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