☆ 4.4 Article

KRAS/NRAS Mutations Associated with Distant Metastasis and BRAF/PIK3CA Mutations Associated with Poor Tumor Differentiation in Colorectal Cancer

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research

Eleonora Spekker et al.

Summary: Migraine is a debilitating primary headache disorder characterized by long-lasting and interfering pain. Neurogenic inflammation and neuropeptides play important roles in the pathophysiology of migraine, and recent advances in preclinical research and therapeutic approaches have provided new insights for its treatment.

BIOMEDICINES (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Microsatellite instability testing in colorectal patients with Lynch syndrome: lessons learned from a case report and how to avoid such pitfalls

Sola Adeleke et al.

Summary: We present a case study of a patient with Lynch syndrome and metastatic colorectal carcinoma (mCRC). The initial immunohistochemistry (IHC) test for mismatch repair deficiency yielded incorrect results, but subsequent testing confirmed the presence of microsatellite instability (MSI). The patient responded positively to immunotherapy, highlighting the importance of accurate testing strategies to guide therapy in mCRC. We advocate for the use of both IHC and MSI-PCR tests and the need for a better understanding of their limitations.

PERSONALIZED MEDICINE (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Role of Alpha Oscillations among the Main Neuropsychiatric Disorders in the Adult and Developing Human Brain: Evidence from the Last 10 Years of Research

Giuseppe Ippolito et al.

Summary: This paper reviews the literature on the role of alpha oscillations in neuropsychiatric disorders over the past decade. It provides a concise account of current models and relevant studies for each disorder, and offers recommendations for future research improvement.

BIOMEDICINES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Accuracy of EEG Biomarkers in the Detection of Clinical Outcome in Disorders of Consciousness after Severe Acquired Brain Injury: Preliminary Results of a Pilot Study Using a Machine Learning Approach

Francesco Di Gregorio et al.

Summary: The study found that functional connectivity and dominant frequency based on EEG can accurately predict clinical outcomes in patients with disorders of consciousness. This has significant implications for making appropriate rehabilitative decisions.

BIOMEDICINES (2022)

添加到收藏夹

Article Health Care Sciences & Services

Surgery for T4 Colorectal Cancer in Older Patients: Determinants of Outcomes

Michael Osseis et al.

Summary: This study compared the outcomes of older and younger patients with T4 colorectal cancer treated with surgery. The results showed that older patients underwent adjuvant therapy less commonly and had a longer delay between surgery and chemotherapy. Older patients had shorter overall survival, but age did not impact relative survival.

JOURNAL OF PERSONALIZED MEDICINE (2022)

添加到收藏夹

Article Immunology

Frequency and coexistence of KRAS, NRAS, BRAF and PIK3CA mutations and occurrence of MMR deficiency in Danish colorectal cancer patients

Tim Svenstrup Poulsen et al.

Summary: Mutations in the MAPK signalling genes KRAS, NRAS, and BRAF, as well as the PIK3CA gene, are routinely investigated in colorectal cancer diagnostics. Co-existing mutations in these genes were found in a small percentage of patients, with a higher frequency of BRAF mutations. Mismatch repair deficiency was present in 14.6% of cases, predominantly characterized by the lack of expression of MLH1 and PMS2 proteins.

APMIS (2021)

添加到收藏夹

Article Pathology

Biomarker alterations associated with distinct patterns of metastatic spread in colorectal cancer

M. Michl et al.

Summary: This study found that different patterns of distant spread in colorectal cancer are associated with specific biomarker alterations, indicating potential different molecular subtypes of the disease.

VIRCHOWS ARCHIV (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cancer Therapy Guided by Mutation Tests: Current Status and Perspectives

Svetlana N. Aleksakhina et al.

Summary: The administration of many cancer drugs is tailored to genetic tests, leading to personalized treatment plans which have significantly improved disease outcomes for a large portion of cancer patients. Genetic testing is now widely used in clinical practice and plays a crucial role in guiding treatment decisions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Review Medicine, General & Internal

Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review

Leah H. Biller et al.

Summary: Colorectal cancer is the third most common cause of cancer mortality worldwide. For patients diagnosed with metastatic colorectal cancer, approximately 70% to 75% can survive beyond 1 year. Tailoring treatments based on the molecular and pathologic features of the tumor has shown to improve overall survival rates.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

添加到收藏夹

Article Oncology

Microsatellite Instability and KRAS Mutation in Stage IV Colorectal Cancer: Prevalence, Geographic Discrepancies, and Outcomes From the National Cancer Database

Johannes Uhlig et al.

Summary: This study found distinct mutational behavior in stage IV colorectal cancer based on microsatellite and KRAS status, with KRAS mutation, MSI-H, and primary CRC sidedness independently affecting overall survival and interacting with different prognostic profiles. Generically classifying adenocarcinomas at different sites as CRC may underestimate this diversity.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Clinicopathological Features and Prognostic Value of KRAS/NRAS/BRAF Mutations in Colorectal Cancer Patients of Central China

Xiao-na Chang et al.

Summary: In Central China, the incidence of colorectal cancer is rising, with high mortality rates. The mutation frequency of KRAS/NRAS/BRAF genes in CRC patients is significant, with BRAF mutation being associated with prognosis.

CURRENT MEDICAL SCIENCE (2021)

添加到收藏夹

Article Oncology

Clinical and prognostic features of patients with detailed RAS/BRAF-mutant colorectal cancer in Japan

Tatsuki Ikoma et al.

Summary: In this study, it was found that CRC patients with KRAS non-Exon2 and NRAS mutations had shorter survival time compared to those with wild-type RAS, and significantly shorter overall survival than patients with KRAS Exon2 mutations in Japan.

BMC CANCER (2021)

添加到收藏夹

Article Medicine, General & Internal

Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020

Wei Cao et al.

Summary: This study summarized the recent changing profiles of cancer burden worldwide and in China, revealing that breast cancer became the most diagnosed cancer globally in 2020. China accounted for 24% of newly diagnosed cases and 30% of cancer-related deaths worldwide in 2020, with a high cancer mortality rate.

CHINESE MEDICAL JOURNAL (2021)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Colorectal liver metastases: ADC as an imaging biomarker of tumor behavior and therapeutic response

Piero Boraschi et al.

Summary: The preADC value can be predictive of the lesion ChT response; PostADC and Delta ADC values are important for evaluating tumor treatment response after preoperative ChT in patients with colorectal liver metastases; There is a significant correlation between TRG and RECIST1.1 criteria in assessing the chemoresponse of liver metastases.

EUROPEAN JOURNAL OF RADIOLOGY (2021)

添加到收藏夹

Letter Clinical Neurology

Don't Hurt Me No More: State-dependent Transcranial Magnetic Stimulation for the treatment of specific phobia

Sara Borgomaneri et al.

JOURNAL OF AFFECTIVE DISORDERS (2021)

添加到收藏夹

Article Oncology

BRAFV600E mutant colorectal cancer cells mediate local immunosuppressive microenvironment through exosomal long noncoding RNAs

Jie Zhi et al.

Summary: BRAF(V600E) mutant colorectal cancer cells can modulate the tumor microenvironment by releasing exosomal long noncoding RNAs, leading to the formation of an immunosuppressive microenvironment. The mutation correlates with elevated serum antigen levels, poor tissue differentiation, increased microvessel density, and M2 macrophage infiltration. Moreover, differential lncRNA and mRNA expression profiles suggest involvement in angiogenesis, tumor proliferation, and metabolic changes.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Prevalence of colorectal cancer biomarkers and their impact on clinical outcomes in Riyadh, Saudi Arabia

Amjad Alharbi et al.

Summary: KRAS mutations were common among Saudi CRC patients, while BRAF mutations were low. The presence of KRAS mutation did not impact survival. Age at diagnosis and gender were significant factors affecting survival time.

PLOS ONE (2021)

添加到收藏夹

Article Oncology

The Spectrum, Tendency and Predictive Value of PIK3CA Mutation in Chinese Colorectal Cancer Patients

Xinhui Fu et al.

Summary: In Chinese CRC patients, the mutation rate of PIK3CA was 13.4%, with an increasing trend from 2014 to 2018. PIK3CA exon 20 mutated patients at stage IV had shorter overall survival, while PIK3CA mutated patients at stage III were more likely to relapse. Cetuximab treatment did not show significant differences in progression-free survival between PIK3CA exon 9 wild-type and mutant patients in KRAS, NRAS, and BRAF wild-type mCRC patients.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

Editorial of Special Issue Crosstalk between Depression, Anxiety, and Dementia: Comorbidity in Behavioral Neurology and Neuropsychiatry

Masaru Tanaka et al.

BIOMEDICINES (2021)

添加到收藏夹

Review Behavioral Sciences

Memories are not written in stone: Re-writing fear memories by means of non-invasive brain stimulation and optogenetic manipulations

Sara Borgomaneri et al.

Summary: The acquisition and extinction of fear associative memory rely on coordinated neural activity within specific brain regions, particularly the amygdala and prefrontal cortex. By comparing brain networks involved in fear processing in humans and other species, we can gain insights into fear mechanisms and potential treatments for fear-related disorders.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

添加到收藏夹

Article Anatomy & Morphology

Clinical Features, Molecular Alterations and Prognosis of Colorectal Adenocarcinoma With Mucinous Component in Chinese Patients

Xiaoli Jia et al.

Summary: The study analyzed the clinicopathologic characteristics, mutation spectrum, and prognosis of colorectal adenocarcinoma with mucinous component (CAWMC), finding that TIL was the most significant predictor of progression-free survival among stage II/III cases. The proportion or variable morphology of mucinous component did not stratify progression-free survival in stage II/III cases.

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Clinical characteristics and prognostic value of the KRAS mutation in Chinese colorectal cancer patients

Ye Yuan et al.

Summary: The study showed that KRAS genes are frequently mutated in Chinese colorectal cancer patients, with over 30% carrying the KRAS G12D mutation subtype, which is associated with inferior survival.

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer

Huashan Liu et al.

Summary: This study reveals a cell-extrinsic role of KRAS in modulating the tumor microenvironment by reprogramming tumor-associated macrophages, promoting tumor progression and inducing resistance to cetuximab therapy. Mechanistically, mutant KRAS stabilizes HIF-1 alpha to drive the production of CSF2 and lactate in tumor cells, enhancing HIF-1 alpha stabilization and contributing to a permissive microenvironment for tumor malignancy.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

添加到收藏夹

Article Oncology

Mutation Status and Prognostic Value of KRAS and BRAF in Southeast Iranian Colorectal Cancer Patients: First Report from Southeast of Iran

Abolfazi Yari et al.

Summary: The study identified mutations in both KRAS and BRAF genes in Iranian colorectal cancer patients and found associations with clinical and clinicopathologic features. The data highlights the importance of these molecular features in Iranian CRC patients.

JOURNAL OF GASTROINTESTINAL CANCER (2021)

添加到收藏夹

Article Medicine, General & Internal

Clinicopathological characteristics and mutational profile of KRAS and NRAS in

Donia Ounissi et al.

Summary: This study found that Tunisian CRC patients have a similar frequency of KRAS and NRAS mutations compared to other populations, highlighting the importance of screening for these mutations to guide therapy and select appropriate candidates, ultimately helping to avoid unnecessary toxicity and increased costs.

TURKISH JOURNAL OF MEDICAL SCIENCES (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Role and molecular mechanism of stem cells in colorectal cancer initiation

Meng-Yan Wang et al.

JOURNAL OF DRUG TARGETING (2020)

添加到收藏夹

Review Oncology

PIK3CA mutation and clinicopathological features of colorectal cancer: a systematic review and Meta-Analysis

Juan Jin et al.

ACTA ONCOLOGICA (2020)

添加到收藏夹

Review Oncology

Brain malignancies: Glioblastoma and brain metastases

Tamara T. Lah et al.

SEMINARS IN CANCER BIOLOGY (2020)

添加到收藏夹

Review Oncology

Implementing anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer: challenges and future perspectives

E. Martinelli et al.

ANNALS OF ONCOLOGY (2020)

添加到收藏夹

Article Pathology

RAS/RAF mutations and their associations with epigenetic alterations for distinct pathways in Vietnamese colorectal cancer

To Van Ta et al.

PATHOLOGY RESEARCH AND PRACTICE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

HER2 and BRAF mutation in colorectal cancer patients: a retrospective study in Eastern China

Xiangyan Zhang et al.

PEERJ (2020)

添加到收藏夹

Article Genetics & Heredity

Effect of Tumor Location on Clinicopathological and Molecular Markers in Colorectal Cancer in Eastern China Patients: An Analysis of 2,356 Cases

Yaolin Song et al.

FRONTIERS IN GENETICS (2020)

添加到收藏夹

Review Oncology

Molecular epidemiology and diagnostics of KRAS mutations in human cancer

Jozsef Timar et al.

CANCER AND METASTASIS REVIEWS (2020)

添加到收藏夹

Review Oncology

Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook

Josep Garcia et al.

CANCER TREATMENT REVIEWS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

KRAS, NRAS, and BRAF mutation prevalence, clinicopathological association, and their application in a predictive model in Mexican patients with metastatic colorectal cancer: A retrospective cohort study

Hector Eduardo Sanchez-Ibarra et al.

PLOS ONE (2020)

添加到收藏夹

Review Oncology

The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy

Daniela Bruni et al.

NATURE REVIEWS CANCER (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Comprehensive review of targeted therapy for colorectal cancer

Yuan-Hong Xie et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

添加到收藏夹

Article Oncology

Molecular characterization of colorectal cancer using whole-exome sequencing in a Taiwanese population

Ya-Sian Chang et al.

CANCER MEDICINE (2019)

添加到收藏夹

Review Oncology

Targeted therapy for colorectal cancer metastases: A review of current methods of molecularly targeted therapy and the use of tumor biomarkers in the treatment of metastatic colorectal cancer

Sorbarikor Piawah et al.

CANCER (2019)

添加到收藏夹

Review Oncology

Targeting EGFR pathway in metastatic colorectal cancer- tumour heterogeniety and convergent evolution

Khurum Khan et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2019)

添加到收藏夹

Article Oncology

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 A Systematic Analysis for the Global Burden of Disease Study

Christina Fitzmaurice et al.

JAMA ONCOLOGY (2019)

添加到收藏夹

Review Medicine, General & Internal

Colorectal cancer

Evelien Dekker et al.

LANCET (2019)

添加到收藏夹

Article Medicine, General & Internal

Brain metastases

Achal Singh Achrol et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

添加到收藏夹

Review Health Care Sciences & Services

The Developing Story of Predictive Biomarkers in Colorectal Cancer

Stergios Boussios et al.

JOURNAL OF PERSONALIZED MEDICINE (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Clinical Impact and Prognostic Role of KRAS/BRAF/PIK3CA Mutations in Stage I Colorectal Cancer

Luca Reggiani Bonetti et al.

DISEASE MARKERS (2018)

添加到收藏夹

Article Pathology

Performance validation of an amplicon-based targeted next-generation sequencing assay and mutation profiling of 648 Chinese colorectal cancer patients

Yajian Wang et al.

VIRCHOWS ARCHIV (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Upregulation of c-mesenchymal epithelial transition expression and RAS mutations are associated with late lung metastasis and poor prognosis in colorectal carcinoma

Jianhua Liu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Mutation status and prognostic values of KRAS, NRAS, BRAF and PIK3CA in 353 Chinese colorectal cancer patients

Fang Guo et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Oncology

Mutation Status and Immunohistochemical Correlation of KRAS, NRAS, and BRAF in 260 Chinese Colorectal and Gastric Cancers

Qiwei Yang et al.

FRONTIERS IN ONCOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Recent Advances in Targeting the EGFR Signaling Pathway for the Treatment of Metastatic Colorectal Cancer

Yuji Miyamoto et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

添加到收藏夹

Article Oncology

Mitochondrial DNA alteration in primary and metastatic colorectal cancer: Different frequency and association with selected clinicopathological and molecular markers

Britta Kleist et al.

TUMOR BIOLOGY (2017)

添加到收藏夹

Review Medicine, General & Internal

Epidermal growth factor receptor (EGFR) inhibitors for metastatic colorectal cancer

David Lok Hang Chan et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2017)

添加到收藏夹

Article Oncology

Mutation Spectra of Common Cancer-Associated Genes in Different Phenotypes of Colorectal Carcinoma Without Distant Metastasis

Shih-Ching Chang et al.

ANNALS OF SURGICAL ONCOLOGY (2016)

添加到收藏夹

Article Oncology

KRAS, BRAF oncogene mutations and tissue specific promoter hypermethylation of tumor suppressor SFRP2, DAPK1, MGMT, HIC1 and p16 genes in colorectal cancer patients

Binnur Bagci et al.

CANCER BIOMARKERS (2016)

添加到收藏夹

Article Gastroenterology & Hepatology

Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer

Vincenzo Sforza et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

添加到收藏夹

Article Oncology

miR-450b-5p induced by oncogenic KRAS is required for colorectal cancer progression

Ya-Ping Ye et al.

ONCOTARGET (2016)

添加到收藏夹

Article Oncology

Molecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: determination of frequency and distribution pattern

Humaid O. Al-Shamsi et al.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2016)

添加到收藏夹

Article Oncology

A retrospective observational study of clinicopathological features of KRAS, NRAS, BRAF and PIK3CA mutations in Japanese patients with metastatic colorectal cancer

Akihito Kawazoe et al.

BMC CANCER (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Molecular spectrum of KRAS, NRAS, BRAF and PIK3CA mutations in Chinese colorectal cancer patients: analysis of 1,110 cases

Jing Zhang et al.

SCIENTIFIC REPORTS (2015)

添加到收藏夹

Article Oncology

B-Raf Inhibitors Induce Epithelial Differentiation in BRAF-Mutant Colorectal Cancer Cells

Ricarda Herr et al.

CANCER RESEARCH (2015)

添加到收藏夹

Article Oncology

BRAF Mutation Predicts for Poor Outcomes After Metastasectomy in Patients With Metastatic Colorectal Cancer

Rona Yaeger et al.

CANCER (2014)

添加到收藏夹

Article Medicine, General & Internal

KRAS, NRAS and BRAF mutations in Greek and Romanian patients with colorectal cancer: a cohort study

Serban Negru et al.

BMJ OPEN (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Effectors of Epidermal Growth Factor Receptor Pathway: The Genetic Profiling of KRAS, BRAF, PIK3CA, NRAS Mutations in Colorectal Cancer Characteristics and Personalized Medicine

Yinchen Shen et al.

PLOS ONE (2013)

添加到收藏夹

Article Medicine, Research & Experimental

Detection of KRAS Mutations and Their Associations with Clinicopathological Features and Survival in Chinese Colorectal Cancer Patients

Z. Li et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2012)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Combined mutational analysis of KRAS, NRAS and BRAF genes in Indian patients with colorectal carcinoma

Sarita B. Bagadi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2012)

添加到收藏夹

Article Anthropology

Tracing the Origins of Hakka and Chaoshanese by Mitochondrial DNA Analysis

Wen-Zhi Wang et al.

AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY (2010)

添加到收藏夹

Article Oncology

KRAS mutations in Slovene patients with colorectal cancer: frequency, distribution and correlation with the response to treatment

Alenka Licar et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2010)

添加到收藏夹

Review Medicine, General & Internal

Molecular Origins of Cancer: Molecular Basis of Colorectal Cancer.

Sanford D. Markowitz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.