期刊
NATURE REVIEWS NEUROSCIENCE
卷 17, 期 10, 页码 652-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn.2016.111
关键词
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资金
- US National Institutes of Health (National Institute of Mental Health (NIMH) [MH-091391, DA-017846, HD-079484]
- National Institute on Drug Abuse (NIDA)
- National Institute of Child Health and Human Development (NICHD)
- Harvard Clinical and Translational Science Center [UL1 TR001102]
Maltreatment-related childhood adversity is the leading preventable risk factor for mental illness and substance abuse. Although the association between maltreatment and psychopathology is compelling, there is a pressing need to understand how maltreatment increases the risk of psychiatric disorders. Emerging evidence suggests that maltreatment alters trajectories of brain development to affect sensory systems, network architecture and circuits involved in threat detection, emotional regulation and reward anticipation. This Review explores whether these alterations reflect toxic effects of early-life stress or potentially adaptive modifications, the relationship between psychopathology and brain changes, and the distinction between resilience, susceptibility and compensation.
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