期刊
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
卷 16, 期 -, 页码 4565-4572出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJGM.S434572
关键词
acute-on-chronic liver failure; hepatitis B virus; prothrombin time-international normalized ratio to albumin ratio; prognosis
This study found that the prothrombin time-international normalized ratio to albumin ratio (PTAR) may be a simple and effective tool for predicting the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure.
Background: Acute-on-chronic liver failure is a common clinical syndrome with high short-term mortality, and early assessment of its mortality risk is crucial, but the search for valid and accurate prognostic biomarkers is a challenging endeavor. The purpose of this study was to investigate the predictive value of the prothrombin time-international normalized ratio to albumin ratio (PTAR) for mortality in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Patients and methods: A total of 354 patients with HBV-ACLF were included in the retrospective study. Patients were divided into survival and non-survival groups based on 90-day follow-up. Cox regression analysis was used to explore the relationship between PTAR and 90-day mortality in patients with HBV-ACLF. The area under the receiver operating characteristic curve was used to evaluate the effectiveness of PTAR in predicting mortality. Results: PTAR was significantly higher in non-survivors than in survivors. The results of multivariate analysis showed that PTAR was a valid independent predictor of mortality in patients with HBV-ACLF. Its predictive ability for mortality was similar to that of the Child-Turcotte-Pugh score, the end-stage liver disease model (MELD) score, and the MELD-sodium score. Conclusion: PTAR may be a simple and effective tool for predicting the prognosis of patients with HBV-ACLF.
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