期刊
NATURE REVIEWS NEUROSCIENCE
卷 17, 期 4, 页码 209-223出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn.2016.18
关键词
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资金
- Research Grants Council of Hong Kong [663811, 663812, AoE-M09-12]
- 973 Program grant from the Minister of Science and Technology of China [2014CB910204]
- National Natural Science Foundation of China [31470733]
Membrane-associated guanylate kinases (MAGUKs) are a family of scaffold proteins that are highly enriched in synapses and are responsible for organizing the numerous protein complexes required for synaptic development and plasticity. Mutations in genes encoding MAGUKs and their interacting proteins can cause a broad spectrum of human psychiatric disorders. Here, we review MAGUK-mediated synaptic protein complex formation and regulation by focusing on findings from recent biochemical and structural investigations. These mechanistic-based studies show that the formation of MAGUK-organized complexes is often directly regulated by protein phosphorylation, suggesting a close connection between neuronal activity and the assembly of dynamic protein complexes in synapses.
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