State of the Art Bowel Management for Pediatric Colorectal Problems: Hirschsprung Disease

Article Pediatrics

Reconstructing the anal sphincters to reverse iatrogenic overstretching following a pull-through for Hirschsprung disease. One-year outcomes

Elizaveta Bokova et al.

Summary: Patients with Hirschsprung disease often suffer from soiling caused by anal sphincter damage. A new technique for sphincter reconstruction has shown promising results in improving bowel control at one year.

JOURNAL OF PEDIATRIC SURGERY (2023)

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Review Pediatrics

Hirschsprung-Associated Enterocolitis at a Referral Institution: A Retrospective Review

Ellen M. Encisco et al.

Summary: This study evaluated a historic cohort of patients with Hirschsprung disease (HD) to determine the incidence of Hirschsprung-associated enterocolitis (HAEC) and to assess the effect of Botox on HAEC incidence. The results showed that 49.5% of the patients experienced at least one episode of HAEC, and 2.9% of the patients received Botox injections at the time of surgery. Further research is needed to determine the impact of Botox on HAEC incidence.

JOURNAL OF PEDIATRIC SURGERY (2023)

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Review Pediatrics

Pediatric Bowel Management Options and Organizational Aspects

Elizaveta Bokova et al.

Summary: A bowel management program is used to treat various colorectal conditions and has been effective in reducing emergency room visits and hospital admissions. Implementation of a multidisciplinary team approach and family education is crucial for postoperative outcomes and prevention of complications. Telemedicine can also be used to improve patient satisfaction and decrease stress.

CHILDREN-BASEL (2023)

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Review Pediatrics

State of the Art Bowel Management for Pediatric Colorectal Problems: Functional Constipation

Elizaveta Bokova et al.

Summary: This paper reports the recent updates on the evaluation and management of children with functional constipation, focusing on patients with anorectal malformations, Hirschsprung disease, spinal anomalies, and functional constipation. The study shows that most of the patients with functional constipation can be managed conservatively, but further studies are needed to determine the optimal strategy of surgical resection in children unresponsive to medical treatment.

CHILDREN-BASEL (2023)

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Review Pediatrics

State of the Art Bowel Management for Pediatric Colorectal Problems: Anorectal Malformations

Elizaveta Bokova et al.

Summary: Up to 79% of patients with ARMs experience constipation and/or soiling after PSARP and are referred to a bowel management program. The evaluation includes an examination under anesthesia and a contrast study to exclude anatomic causes of poor bowel function. The bowel management options include laxatives, rectal enemas, transanal irrigations, and antegrade continence enemas.

CHILDREN-BASEL (2023)

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Article Pediatrics

Routine botulinum toxin injection one month after a Swenson pull-through does not change the incidence of Hirschsprung associated enterocolitis

Hira Ahmad et al.

Summary: The purpose of this study was to determine if routine postoperative botulinum toxin injection given one month after pull-through surgery reduces the incidence of Hirschsprung associated enterocolitis (HAEC). The study results showed no significant difference in HAEC incidence between the group that received routine botulinum toxin injection and the group that did not receive it.

JOURNAL OF PEDIATRIC SURGERY (2022)

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Article Pediatrics

Hirschsprung disease in Down syndrome: An opportunity for improvement

Rebecca A. Saberi et al.

Summary: This study analyzed the clinical characteristics and outcomes of patients with Down syndrome and Hirschsprung disease. The results showed that patients with Down syndrome experienced delays in diagnosis, longer hospital stays for surgical patients, and a higher mortality rate.

JOURNAL OF PEDIATRIC SURGERY (2022)

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Article Surgery

Outpatient Botulinum Injections for Early Obstructive Symptoms in Patients with Hirschsprung Disease

Wendy Jo Svetanoff et al.

Summary: Outpatient Botulinum toxin injections are associated with decreased episodes of Hirschsprung associated enterocolitis (HAEC) and increased interval between HAEC episodes requiring inpatient treatment. Scheduling outpatient BT injections to manage obstructive symptoms after pull-through for Hirschsprung disease (HSCR) may be beneficial.

JOURNAL OF SURGICAL RESEARCH (2022)

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Article Pediatrics

Prevalence of Hirschsprung-associated enterocolitis in patients with Hirschsprung disease

J. Hagens et al.

Summary: This systematic review aimed to clarify the prevalence of Hirschsprung's associated enterocolitis (HAEC) in short-(S-HD), long (L-HD), TCA, and the type of operation used. The study found that the prevalence of preoperative HAEC increases with segment length, but postoperative risk for developing HAEC is comparable to the preoperative risk, regardless of the employed method and segment length.

PEDIATRIC SURGERY INTERNATIONAL (2022)

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Review Gastroenterology & Hepatology

Colonic Function Investigations in Children: Review by the ESPGHAN Motility Working Group

Anna Rybak et al.

Summary: This review discusses the common causes of colonic motility disorders in children, with a focus on recent advances in testing methods, including both classical and novel techniques.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2022)

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Review Pediatrics

Psychosocial factors affecting quality of life in patients with anorectal malformation and Hirschsprung disease-a qualitative systematic review

Wendy Jo Svetanoff et al.

Summary: This study identified various psychosocial and behavioral challenges faced by ARM and HSCR patients at different developmental stages. From uncertainty and lack of social support in the neonatal period to anxiety, peer rejection, and behavioral problems in primary grades, as well as low self-confidence, poor body image, and depression in adolescents, and hesitancy in engaging in romantic relationships or sexual activity in young adults, the study highlights the importance of developmentally matched medical, psychological, and community-based supports for these patients and their families to improve their quality of life.

JOURNAL OF PEDIATRIC SURGERY (2022)

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Article Pediatrics

Transition and reversal: long-term experience of the MACE procedure in children

Riyad Peeraully et al.

Summary: This study analyzed the outcomes and follow-up of children who underwent the Malone antegrade continence enema (MACE) procedure in a UK tertiary paediatric surgery unit. The study found a success rate of 72% for the MACE procedure in the unit, with a significant difference in reversal rate between diagnostic groups. Approximately one-fifth of the patients no longer required the MACE procedure after long-term follow-up, and 50% of patients over 16 years old were transitioned to adult services.

PEDIATRIC SURGERY INTERNATIONAL (2022)

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Article Pediatrics

Comparison of Hirschsprung Disease Characteristics between Those with a History of Postoperative Enterocolitis and Those without: Results from the Pediatric Colorectal and Pelvic Learning Consortium

Mark A. Taylor et al.

Summary: This study found that patients with a rectosigmoid transition zone have lower incidence of postoperative HAEC, and private insurance may provide some protection against postoperative HAEC, though preoperative HAEC was not associated with the development of postoperative HAEC.

EUROPEAN JOURNAL OF PEDIATRIC SURGERY (2021)

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Article Pediatrics

A technique to reconstruct the anal sphincters following iatrogenic stretching related to a pull-through for Hirschsprung disease

Wilfried Krois et al.

Summary: Soiling and fecal incontinence are troublesome complications that can occur after surgery for Hirschsprung disease. Proper medical management can usually improve these issues, but in some cases, they may result from anatomical defects that require a structured bowel management program for treatment.

JOURNAL OF PEDIATRIC SURGERY (2021)

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Letter Pediatrics

Regarding: Timing of the definitive procedure and ileostomy closure for total colonic aganglionosis HD: Systematic review

Marc A. Levitt

JOURNAL OF PEDIATRIC SURGERY (2021)

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Article Surgery

Impact of Botulinum Toxin on Hirschsprung-Associated Enterocolitis After Primary Pull-Through

Rebecca M. Rentea et al.

Summary: A retrospective cohort study involving 1439 children with HSCR found that prophylactic BT administration after primary pull-through surgery did not increase the time to first HAEC event. Further research is needed to determine the effect of prophylactic BT on HAEC occurrence and timing.

JOURNAL OF SURGICAL RESEARCH (2021)

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Article

Evaluation and Management of Persistent Problems After Surgery for Hirschsprung Disease in a Child

Hira Ahmad et al.

Current Gastroenterology Reports (2021)

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Letter Pediatrics

The impact of botulinum injection for hospitalized children with Hirschsprung-associated enterocolitis

Wendy Jo Svetanoff et al.

Summary: This retrospective study found that patients with HAEC who received BT treatment had longer intervals between recurrent episodes and trended towards fewer readmissions. Therefore, the use of BT should be considered in the management of HAEC patients.

PEDIATRIC SURGERY INTERNATIONAL (2021)

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Article Pediatrics

Primary laparoscopic endorectal pull-through procedure with or without a postoperative rectal tube for hirschsprung disease: a multicenter perspective study

Xi Zhang et al.

JOURNAL OF PEDIATRIC SURGERY (2020)

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Review Pediatrics

Total Colonic Hirschsprung's Disease: The Hypermotility and Skin Rash Protocol

Alejandra Vilanova-Sanchez et al.

EUROPEAN JOURNAL OF PEDIATRIC SURGERY (2020)

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Article Pediatrics

Hirschsprung-associated enterocolitis in children treated at US children's hospitals

Liese C. C. Pruitt et al.

JOURNAL OF PEDIATRIC SURGERY (2020)

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Article Pediatrics

Intermediate and long-term outcomes of a bowel management program for children with severe constipation or fecal incontinence

Julie A. Kilpatrick et al.

JOURNAL OF PEDIATRIC SURGERY (2020)

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Article Pathology

Postoperative Pullthrough Obstruction in Hirschsprung Disease: Etiologies and Diagnosis

Raj P. Kapur et al.

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY (2020)

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Article Surgery

Does Hirschsprung-Associated Enterocolitis Differ in Children With and Without Down Syndrome?

Devin R. Halleran et al.

JOURNAL OF SURGICAL RESEARCH (2020)

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Review Gastroenterology & Hepatology

Long-term outcomes and quality of life of patients with Hirschsprung disease: a systematic review and meta-analysis

Ying Dai et al.

BMC GASTROENTEROLOGY (2020)

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Article Pediatrics

Use of an enterocolitis triage and treatment protocol in children with Hirschsprung disease reduces hospital admissions

Natalie Wall et al.

JOURNAL OF PEDIATRIC SURGERY (2020)

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Article Pediatrics

Inpatient management of Hirschsprung's associated enterocolitis treatment: the benefits of standardized care

Wendy Jo Svetanoff et al.

PEDIATRIC SURGERY INTERNATIONAL (2020)

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Article Pediatrics

Medical alert card: a valuable tool in the management of Hirschsprung's-associated enterocolitis from parental perspective

Ancuta Muntean et al.

PEDIATRIC SURGERY INTERNATIONAL (2020)

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Article Pediatrics

Bowel management for the treatment of fecal incontinence and constipation in patients with anorectal malformations

Onnalisa Nash et al.

SEMINARS IN PEDIATRIC SURGERY (2020)

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Review Pediatrics

Guidelines for the management of postoperative soiling in children with Hirschsprung disease

P. Saadai et al.

PEDIATRIC SURGERY INTERNATIONAL (2019)

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Review Gastroenterology & Hepatology

Botulinum toxin injections after surgery for Hirschsprung disease: Systematic review and meta-analysis

Danielle Roorda et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Article Pediatrics

Long-term outcomes of antegrade continence enema in children with chronic encopresis and incontinence: what is the optimal flush to use?

Suniah S. Ayub et al.

PEDIATRIC SURGERY INTERNATIONAL (2019)

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Review Pediatrics