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Combined use of total glucosides of paeony and hydroxychloroquine in primary Sjögren's syndrome: A systematic review

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IMMUNITY INFLAMMATION AND DISEASE
卷 11, 期 10, 页码 -

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WILEY
DOI: 10.1002/iid3.1044

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hydroxychloroquine; primary Sjogren's syndrome; total glucosides of paeony

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This meta-analysis demonstrates that the combination of total glucosides of paeony (TGP) and hydroxychloroquine (HCQ) has significant therapeutic effects for primary Sjo''gren's syndrome (pSS). In clinical practice, TGP + HCQ can be considered as a potentially effective and safe combination treatment for pSS.
Objective: To assess the effectiveness and safety of the total glucosides of paeony (TGP) combined with hydroxychloroquine (HCQ) on the treatment of primary Sjo''gren's syndrome (pSS) by conducting a meta-analysis.Methods: Eight databases were searched for randomized controlled trials (RCTs) reporting the use of TGP combined with HCQ for pSS, which are before May 10, 2022. Meta-analyses were performed on disappeared clinical symptoms (dry mouth and dry eyes), Schirmer's test, saliva flow test, erythrocyte sedimentation rate (ESR), index of immunoglobulin G (IgG), immunoglobulin M (IgM), immunoglobulin A (IgA), and adverse events (AEs). The Revman 5.4 software was used for this meta-analysis.Results: Seven RCTs which included 632 participants were identified. The pooled results showed significant differences in clinical symptoms disappear (dry mouth and dry eyes) (p = .0004), IgM (p < .00001), IgA (p < .00001), salivary flow rate (p < .00001) and Schirmer's test (p = .02) in the comparison of TGP combined with HCQ and HCQ alone. For the IgG and ESR, both pooled and subgroup analyses showed that TGP + HCQ was superior to HCQ alone. For the safety analysis, no significant differences in AEs (p = .39) was revealed. The more frequently seen adverse reactions were diarrhea, vomit and there was no severe adverse events were reported in TGP + HCQ group.Conclusion: Therefore, TGP + HCQ can be considered to be a potentially valid and safe combination for the treatment of pSS in the clinic.

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