期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 17, 期 4, 页码 213-226出版社
NATURE RESEARCH
DOI: 10.1038/nrm.2016.23
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资金
- European Molecular Biology Organization (EMBO) [ALTF 480-2014]
- Ecole Polytechnique Federale de Lausanne
- Swiss National Science Foundation [31003A-140780]
- AgingX programme of the Swiss Initiative for Systems Biology [51RTP0-151019]
- Krebsforschung Schweiz/Swiss Cancer League [KFS-3082-02-2013]
- US National Institutes of Health (NIH) [R01AG043930]
Mitochondria participate in crucial cellular processes such as energy harvesting and intermediate metabolism. Although mitochondria possess their own genome - a vestige of their bacterial origins and endosymbiotic evolution - most mitochondrial proteins are encoded in the nucleus. The expression of the mitochondrial proteome hence requires tight coordination between the two genomes to adapt mitochondrial function to the ever-changing cellular milieu. In this Review, we focus on the pathways that coordinate the communication between mitochondria and the nucleus during homeostasis and mitochondrial stress. These pathways include nucleus-to-mitochondria (anterograde) and mitochondria-to-nucleus (retrograde) communication, mitonuclear feedback signalling and proteostasis regulation, the integrated stress response and non-cell-autonomous communication. We discuss how mitonuclear communication safeguards cellular and organismal fitness and regulates lifespan.
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