期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 17, 期 8, 页码 496-510出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2016.67
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资金
- Cancer Research UK [C6620/A15961]
- King's Bioscience Institute
- Guy's and St Thomas' Charity Prize Ph.D. Programme in Biomedical and Translational Science
- Cancer Research UK [15961] Funding Source: researchfish
Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a wide range of cellular processes, including cell migration, cell polarity and cell cycle progression. Most Rho GTPases cycle between a GTP-bound active conformation and a GDP-bound inactive conformation to regulate their ability to activate effector proteins and to elicit cellular responses. However, it has become apparent that Rho GTPases are regulated by post-translational modifications and the formation of specific protein complexes, in addition to GTP-GDP cycling. The canonical regulators of Rho GTPases - guanine nucleotide exchange factors, GTPase-activating proteins and guanine nucleotide dissociation inhibitors - are regulated similarly, creating a complex network of interactions to determine the precise spatiotemporal activation of Rho GTPases.
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