Differential Expression of Serum Proinflammatory Cytokine TNF-α and Genetic Determinants of TNF-α, CYP2C19*17, miR-423 Genes and Their Effect on Coronary Artery Disease Predisposition and Progression

Article Cardiac & Cardiovascular Systems

CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study

Nan Cai et al.

Summary: The study found that there is a relationship between CYP2C19 gene polymorphisms and hypertension in the Hakka population. Loss-of-function genotypes of CYP2C19 increase the risk of hypertension.

BMC CARDIOVASCULAR DISORDERS (2023)

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Article Medicine, General & Internal

Integrating Coronary Atherosclerosis Burden and Progression with Coronary Artery Disease Risk Factors to Guide Therapeutic Decision Making

Andrew M. Freeman et al.

Summary: This article introduces a precision heart care approach that focuses on atherosclerosis as the primary target for evaluation and treatment. By directly quantifying and characterizing atherosclerosis, it aims to improve diagnosis, risk stratification, therapeutic decision-making, and personalized disease tracking. The American College of Cardiology has introduced the Atherosclerosis Treatment Algorithms, which personalize medical interventions based on coronary computed tomography angiography findings and cardiovascular risk factors, leveraging atherosclerosis burden and progression as primary targets for therapeutic intervention.

AMERICAN JOURNAL OF MEDICINE (2023)

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Article Biology

Association of Genetic and Allelic Variants of Von Willebrand Factor (VWF), Glutathione S-Transferase and Tumor Necrosis Factor Alpha with Ischemic Stroke Susceptibility and Progression in the Saudi Population

Mohammed M. Jalal et al.

Summary: Stroke is a major cerebrovascular disease that has significant impacts on patients and society as a whole. The interaction of certain gene variations with high blood pressure, diabetes, and smoking may increase the incidence of ischemic stroke. This study examined the associations of SNPs in VWF, GSTs, and TNF-alpha genes with stroke in the Saudi population, and found significant differences in genotypes between stroke cases and healthy controls. The results suggest a strong association between certain gene variants and susceptibility to ischemic stroke in the Saudi population, but further studies are needed to confirm these findings and understand their effects on proteins.

LIFE-BASEL (2023)

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Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association

Connie W. Tsao et al.

Summary: This article introduces the latest statistics on heart disease, stroke, and cardiovascular risk factors published by the American Heart Association in conjunction with the National Institutes of Health. The Statistical Update includes data on a range of clinical heart and circulatory disease conditions and their associated outcomes. It serves as a critical resource for the general public, policymakers, healthcare professionals, researchers, and others seeking the best available data.

CIRCULATION (2022)

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Article Biochemistry & Molecular Biology

Genetic Variation in MicroRNA-423 Promotes Proliferation, Migration, Invasion, and Chemoresistance in Breast Cancer Cells

Sebastian Morales-Pison et al.

Summary: The rs6505162:A allele plays an important role in mammary tumorigenesis by promoting breast cancer cell proliferation, chemoresistance, migration, invasion, and inhibiting apoptosis. This finding may have implications for early diagnosis, prognosis, and treatment of breast cancer patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Cardiac & Cardiovascular Systems

Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

Suzanne E. Engelen et al.

Summary: This review provides an overview of the role of the immune system in atherosclerosis. By discussing findings from preclinical research and clinical trials, it reveals the potential and challenges of targeting inflammation and the immune system in the treatment of atherosclerosis.

NATURE REVIEWS CARDIOLOGY (2022)

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Article Oncology

Potential impact of GCK, MIR-196A-2 and MIR-423 gene abnormalities on the development and progression of type 2 diabetes mellitus in Asir and Tabuk regions of Saudi Arabia

Mohammad Muzaffar Mir et al.

Summary: This study investigates the association of single nucleotide polymorphisms (SNPs) in the GCK, MIR-196A-2, and MIR-423 genes with susceptibility to type 2 diabetes mellitus (T2DM) in patients from two regions of Saudi Arabia. The results suggest that genetic variations in these genes may be potentially associated with an increased risk of T2DM.

MOLECULAR MEDICINE REPORTS (2022)

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Article Cardiac & Cardiovascular Systems

Serum Cytokines Predict the Severity of Coronary Artery Disease Without Acute Myocardial Infarction

Sheng Liu et al.

Summary: This study investigated the relationship between serum cytokines and the severity of coronary artery disease (CAD) in patients with non-acute myocardial infarction (AMI). It found that serum levels of IL-4, IL-12p70, IL-17, and IFN-alpha were significantly lower in the severe CAD group compared to the non-severe CAD group. IL-12p70 and IL-17 were negatively correlated with the severity of CAD. The study also identified IL-12p70, IL-17, HDL-C, gender, and diabetes as independent predictors of severe CAD.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Endocrinology & Metabolism

Association Between Insulin Resistance and Cardiovascular Disease Risk Varies According to Glucose Tolerance Status: A Nationwide Prospective Cohort Study

Tiange Wang et al.

Summary: This study aimed to investigate the interaction between insulin resistance and cardiovascular disease (CVD) risk in different glucose tolerance statuses. Using data from the China Cardiometabolic Disease and Cancer Cohort Study, the researchers found that glucose intolerance exacerbates the association between insulin resistance and CVD risk. Both insulin resistance and obesity in individuals with prediabetes were associated with higher risks of CVD, while insulin resistance remained a risk factor for CVD in individuals with diabetes, regardless of obesity status.

DIABETES CARE (2022)

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Article Biochemistry & Molecular Biology

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations

Catherine Tcheandjieu et al.

Summary: This study incorporates a diverse cohort of individuals to explore the genetic landscape of coronary artery disease. The researchers discovered novel loci associated with the disease in different ancestral groups, and identified common haplotypes that contribute to risk stratification. They also found genetic overlaps between coronary artery disease and clinical coronary atherosclerosis, and related these genetic factors to insulin resistance and other traits.

NATURE MEDICINE (2022)

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Article

Pharmacogenetics of CYP2C1917: Functional and Clinical Implications of CYP2C1917 - rs12248560 (c.-806C>T) in the Development of Type 2 Diabetes

Imadeldin Elfaki et al.

Biomedical and Pharmacology Journal (2022)

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Review Biochemistry & Molecular Biology

Pathophysiology of Cardiovascular Diseases: New Insights into Molecular Mechanisms of Atherosclerosis, Arterial Hypertension, and Coronary Artery Disease

Weronika Frak et al.

Summary: Cardiovascular diseases (CVDs) are disorders associated with the heart and circulatory system, with atherosclerosis as its underlying cause. CVDs are the leading cause of morbidity and mortality globally, creating a significant public health concern. This review summarizes the pathophysiological implications of CVDs, focusing on coronary artery disease and atherosclerosis. Inflammatory factors and genetic risk factors have been identified in association with CVDs.

BIOMEDICINES (2022)

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Review Biochemistry & Molecular Biology

The Role of Inflammation in Cardiovascular Disease

Michael Y. Henein et al.

Summary: Atherosclerosis is a chronic inflammatory disease and the immune system plays a significant role in its development and progression. Inflammation-induced endothelial dysfunction leads to the accumulation of lipoproteins and the formation of plaques. Chronic inflammation and psychological stress increase the risk of cardiovascular disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Cardiac & Cardiovascular Systems

The Effect of TNF-α on CHD and the Relationship between TNF-α Antagonist and CHD in Rheumatoid Arthritis: A Systematic Review

Yezhou Qian et al.

Summary: TNF-alpha plays a crucial role in the pathogenesis of CHD and RA, and TNF-alpha antagonists may reduce the risk of CHD in patients with RA.

CARDIOLOGY RESEARCH AND PRACTICE (2022)

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Review Cardiac & Cardiovascular Systems

Hypertension as a risk factor for atherosclerosis: Cardiovascular risk assessment

Anastasia V. Poznyak et al.

Summary: Atherosclerosis, a predecessor of cardiovascular diseases, has a high morbidity and mortality rate. However, the trigger mechanism is not well understood. Hypertension, among the various modifiable risk factors, is considered the most widespread and extensively researched factor for atherosclerosis development.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

Prevalence of coronary artery disease and its risk factors in Majmaah City, Kingdom of Saudi Arabia

Haitham M. Albar et al.

Summary: This study aimed to outline the prevalence of coronary artery diseases in a specific region of Saudi Arabia. It involved a retrospective observational study across five medical centers, focusing on patients admitted for CAD. The results showed that CAD is the leading cause of heart failure in the region, with a high prevalence of comorbidities such as hypertension and diabetes.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Review Cardiac & Cardiovascular Systems

NF-κB and its crosstalk with endoplasmic reticulum stress in atherosclerosis

Wenjing Li et al.

Summary: This review summarizes the interactions between the primary transcription factor NF-kappa B and endoplasmic reticulum stress (ER stress) in the progression of atherosclerosis (AS). NF-kappa B and ER stress play critical roles in the pathogenesis of AS and have overlapping molecular regulation and function.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

Atherosclerotic cardiovascular disease risk assessment: An American Society for Preventive Cardiology clinical practice statement

Nathan D. Wong et al.

Summary: The risk for atherosclerotic cardiovascular disease (ASCVD) varies significantly in both generally healthy individuals and those with known ASCVD. Preventive cardiology focuses on assessing baseline ASCVD risk and using lifestyle management and pharmacologic therapy to reduce risk based on risk scores. Additional factors like traditional risk factors, novel biomarkers, and inflammatory factors can further assess ASCVD risk, especially in borderline or intermediate risk cases. Accurate risk assessment is crucial in targeting preventive therapies for ASCVD.

AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY (2022)

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Review Biochemistry & Molecular Biology

The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics

Dan-in Jang et al.

Summary: TNF-α was originally identified as a factor causing tumor necrosis but has also been recognized as a pathological component of autoimmune diseases. Its signaling pathways play important roles in cellular responses, and inappropriate activation can lead to chronic inflammation and autoimmune diseases. TNF-α inhibitors have been developed as effective therapeutic tools for various autoimmune diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell Biology

HDL in Atherosclerotic Cardiovascular Disease: In Search of a Role

Manuela Casula et al.

Summary: Recent studies on the role of high-density lipoprotein cholesterol (HDL-C) in cardiovascular disease have found a complex U-shaped relationship between HDL levels and cardiovascular mortality risk. Additionally, genetic studies, Mendelian randomization approaches, and clinical trials have challenged the traditional notion of a causal link between HDL-C levels and cardiovascular protection.

CELLS (2021)

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Article Cell Biology

Analysis of miRNAs Profiles in Serum of Patients With Steatosis and Steatohepatitis

Maria Vulf et al.

Summary: The study identified differential expression of miRNAs at different stages of NAFLD development and their regulatory effects on genes; analysis of target genes and metabolic pathways revealed changes in RNA-dependent epigenetic regulation in steatosis and steatohepatitis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Endocrinology & Metabolism

Association of TNF-α-308 G>A (rs1800629) polymorphism with susceptibility of metabolic syndrome

Dalia Ghareeb et al.

Summary: This study found a significant association between TNF-alpha-308 G > A (rs1800629) polymorphism and susceptibility to metabolic syndrome, with the A allele being a strong predictor in Egyptians. Positive correlations were also observed between the TNF-alpha-308 (G/A) polymorphism and risk factors of metabolic syndrome such as body mass index, fasting blood sugar, cholesterol, and low density lipoprotein.

JOURNAL OF DIABETES AND METABOLIC DISORDERS (2021)

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Editorial Material Cardiac & Cardiovascular Systems

From GWAS Association to Function Candidate Gene Screening Within Insulin Resistance-Associated Genomic Loci Using a Preadipocyte Differentiation Model

Feria A. Ladha et al.

CIRCULATION RESEARCH (2020)

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Review Peripheral Vascular Disease

High Blood Pressure and Cardiovascular Disease

Flavio D. Fuchs et al.

HYPERTENSION (2020)

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Cytochrome P450 2E1 and its roles in disease

F. Peter Guengerich

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

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Association between CYP2C19 gene polymorphisms and lipid metabolism in Chinese patients with ischemic stroke

Yunxue Bai et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)

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Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study

Shuai Yuan et al.

EBIOMEDICINE (2020)

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Complexity of TNF-α Signaling in Heart Disease

Filip Rolski et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration

Morteza Sarparast et al.

NUTRIENTS (2020)

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MicroRNAs Regulate Metabolic Phenotypes During Multicellular Tumor Spheroids Progression

Erick Andres Mucino-Olmos et al.

FRONTIERS IN ONCOLOGY (2020)

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microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis

Tiziana Annese et al.

FRONTIERS IN ONCOLOGY (2020)

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MiR-423 is differentially expressed in patients with stable and unstable coronary artery disease: A pilot study

Barbara Rizzacasa et al.

PLOS ONE (2019)

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Potential Impact of MicroRNA-423 Gene Variability in Coronary Artery Disease

Chandan K. Jha et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2019)

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Dyslipidemia Associated with Hypertension Increases the Risks for Coronary Heart Disease: A Case-Control Study in Harapan Kita Hospital, National Cardiovascular Center, Jakarta

Rea Ariyanti et al.

JOURNAL OF LIPIDS (2019)

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Review Immunology

Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based

Massimo Fioranelli et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Jacob O'Brien et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

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Mechanisms of Cytochrome P450-Catalyzed Oxidations

F. Peter Guengerich

ACS CATALYSIS (2018)

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Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice

Alexandros Nicolaou et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)

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Hypertriglyceridemia and atherosclerosis

Jia Peng et al.

LIPIDS IN HEALTH AND DISEASE (2017)

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Interaction of IL-6 and TNF-α contributes to endothelial dysfunction in type 2 diabetic mouse hearts

Jonghae Lee et al.

PLOS ONE (2017)

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NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway

Weili Yang et al.

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Inflammatory cytokines in atherosclerosis: current therapeutic approaches

Dimitris Tousoulis et al.

EUROPEAN HEART JOURNAL (2016)

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Renal Tumor Necrosis Factor α Contributes to Hypertension in Dahl Salt-Sensitive Rats

Baorui Huang et al.

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Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals

Slobodan Rendic et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2015)

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Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases

Paul R. Clark et al.

PLOS ONE (2015)

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Genetic variation at the CYP2C19 gene associated with metabolic syndrome susceptibility in a South Portuguese population: results from the pilot study of the European Health Examination Survey in Portugal

Vania Gaio et al.

DIABETOLOGY & METABOLIC SYNDROME (2014)

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Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

Ulrich M. Zanger et al.

PHARMACOLOGY & THERAPEUTICS (2013)

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Tumor necrosis factor-α: regulation of renal function and blood pressure

Vanesa D. Ramseyer et al.

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Cytochrome P450s in the Regulation of Cellular Retinoic Acid Metabolism

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ANNUAL REVIEW OF NUTRITION, VOL 31 (2011)

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MiR423-5p As a Circulating Biomarker for Heart Failure

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CIRCULATION RESEARCH (2010)

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Differential Expression of Serum Proinflammatory Cytokine TNF-α and Genetic Determinants of TNF-α, CYP2C19*17, miR-423 Genes and Their Effect on Coronary Artery Disease Predisposition and Progression

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