A Review Study of the Participation of Late Domains in Sorting and Transport of Viral Factors to Exosomes

Cellular communication depends heavily on the participation of vesicular systems generated by most cells of an organism. Exosomes play central roles in this process. Today, these vesicles have been characterized, and it has been determined that the cargo they transport is not within a random system. In fact, it depends on various molecular signals and the recruitment of proteins that participate in the biogenesis of exosomes. It has also been shown that multiple viruses can recruit these vesicles to transport viral factors such as genomes or proteins. It has been shown that the late domains present in viral proteins are critical for the exosomal selection and biogenesis systems to recognize these viral proteins and introduce them into the exosomes. In this review, the researchers discuss the evidence related to the characterization of these late domains and their role in exosome recruitment during viral infection.

Automated summary

Cellular communication relies on vesicular systems, especially exosomes, which transport cargo influenced by various molecular signals and proteins involved in exosome biogenesis. Viruses can recruit exosomes to transport viral factors, and the late domains in viral proteins are crucial for exosomal selection and biogenesis.