☆ 4.5 Review

Recent Advances in Functionalization Strategies for Biosensor Interfaces, Especially the Emerging Electro-Click: A Review

CHEMOSENSORS (2023)

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Article Chemistry, Multidisciplinary

Site-Specific Introduction of Bioorthogonal Handles to Nanopores by Genetic Code Expansion

Jing Yang et al.

Summary: This study presents a genetic code expansion strategy to introduce unnatural amino acids into the Mycobacterium smegmatis porin A (MspA) nanopore, enabling the rapid and efficient introduction of bioorthogonal reactive sites and the conjugation with single stranded DNA or lysozyme. The lysozyme-conjugated pore demonstrated the ability to discriminate between different oligosaccharides, which a bare MspA nanopore does not possess. This genetic code expansion strategy with bioorthogonal handles is a versatile method for nanopore engineering and may expand the application scenarios of nanopores.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

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Article Biophysics

Advances in electrochemiluminescence luminophores based on small organic molecules for biosensing

Kaiqing Wu et al.

Summary: Electrochemiluminescence (ECL) has various advantages and is widely used for sensing, imaging, and single cell analysis. Small organic ECL luminophores, with their biocompatibility and easy modification, play a key role in the performance of ECL applications. However, there is a lack of comprehensive reviews on small organic ECL luminophores. This review introduces the advantages, emission mechanisms, types, molecular characteristics, and applications of small organic ECL luminophores, and discusses the challenges and prospects in biosensing applications.

BIOSENSORS & BIOELECTRONICS (2023)

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Review Pharmacology & Pharmacy

Click chemistry and drug delivery: A bird's-eye view

Shameer M. Kondengadan et al.

Summary: Click chemistry has proven to be useful in drug delivery, but selecting the appropriate chemistry is not easy. This review provides an overview of available click reactions for pharmaceutical researchers interested in click chemistry applications. It emphasizes the analysis of reaction kinetics, concentration effects, and reaction time scales to avoid failures. The review also discusses issues like chemical stability and provides recent examples and extensive references for a better understanding of technical details.

ACTA PHARMACEUTICA SINICA B (2023)

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Review Chemistry, Multidisciplinary

Copper-Free Click Chemistry: Applications in Drug Delivery, Cell Tracking, and Tissue Engineering

Hong Yeol Yoon et al.

Summary: Traditional organic chemical reactions often require organic solvents, toxic catalysts, heat, or high pressure. However, copper-free click chemistry offers a more favorable alternative with its fast reaction rates and orthogonality in water, buffer solutions, and physiological conditions without the need for toxic catalysts. This has led to its growing interest in biomedical research, where it has been used in various applications such as molecular imaging and therapy.

ADVANCED MATERIALS (2022)

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Article Biophysics

Simultaneous detection of dual biomarkers using hierarchical MoS2 nanostructuring and nano-signal amplification-based electrochemical aptasensor toward accurate diagnosis of prostate cancer

Ruohong Yan et al.

Summary: The study introduces an electrochemical aptasensor using MoS2 nanostructuring and SiO2 nano-signal amplification for simultaneous detection of PSA and sarcosine in prostate cancer. This approach allows for ultrasensitive detection, differentiation of cancer patients from healthy individuals, and provides a single-step analysis for accurate diagnosis and early detection of cancer in clinical settings.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Chemistry, Physical

Functional plasma-polymerized hydrogel coatings for electrochemical biosensing

Monique Levien et al.

Summary: Acrylate-based hydrogels have been proven to be excellent materials for sensor systems. In this study, hydrogels made of hydroxyethyl methacrylate and 2-(diethylamino)ethyl methacrylate were generated by atmospheric pressure plasma jet. The interaction capability of these hydrogels with biomolecules and their application in electrochemical biosensing were investigated.

APPLIED SURFACE SCIENCE (2022)

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Article Biophysics

CRISPR/Cas12a-Derived electrochemical aptasensor for ultrasensitive detection of COVID-19 nucleocapsid protein

Cong Han et al.

Summary: In this study, a CRISPR/Cas12a-derived electrochemical aptasensor for fast and ultrasensitive detection of COVID-19 nucleocapsid protein (Np) was developed. The sensor exhibited high selectivity to Np and could complete a test within 30 minutes. It showed great potential in early diagnosis of COVID-19, environmental surveillance, and food security.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Engineering, Environmental

A graphdiyne-based protein molecularly imprinted biosensor for highly sensitive human C-reactive protein detection in human serum

Min Cui et al.

Summary: A highly sensitive protein MIPs biosensor was developed for the selective recognition of human C-reactive protein. The biosensor combined conductive and biocompatible graphdiyne nanosheets, antifouling MIPs, and utilized dopamine as a functional monomer. The biosensor showed excellent selectivity, reversibility, reusability, as well as good antifouling ability, sensitivity, and stability.

CHEMICAL ENGINEERING JOURNAL (2022)

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Review Engineering, Environmental

DNAzyme-based biosensors for mercury (II) detection: Rational construction, advances and perspectives

Zehua Cheng et al.

Summary: Mercury contamination is a severe issue in society due to its threats to public health and the ecological system. Traditional methods for mercury ion detection have limitations in terms of time-consuming procedures, requirement of expensive instruments, and low selectivity. Functional nucleic acid-based DNAzyme sensors have shown great potential in mercury determination. This review comprehensively summarizes the studies on DNAzyme-based sensors for mercury detection using various sensing techniques and discusses their design strategies, properties, and recent advances.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Article Chemistry, Analytical

Electrochemical aptasensor based on electrodeposited poly(3,4-ethylenedioxythiophene)-graphene oxide coupled with Au@ Pt nanocrystals for the detection of 17β-estradiol

Zhi Zhao et al.

Summary: This paper reports an electrochemical aptasensor for the monitoring of 17 beta-estradiol. The sensor shows excellent selectivity, stability, and reproducibility, and has successfully been tested in human serum, lake water, and tap water samples.

MICROCHIMICA ACTA (2022)

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Review Chemistry, Multidisciplinary

DNA Supramolecular Assembly on Micro/Nanointerfaces for Bioanalysis

Chi Yao et al.

Summary: Facing the increasing demand for precision medicine, materials chemistry systems with accurate molecular design, controllable structure, and adjustable biological activity are required for bioanalysis. In recent years, DNA has been considered a potential biomaterial for analysis and has been applied in various fields. DNA supramolecular assembly on micro/nanointerfaces is an effective strategy to concentrate functional DNA modules and enhance their functions in bioanalysis. This research direction is expected to guide the construction of more bioanalytical materials and promote the development of precision medicine.

ACCOUNTS OF CHEMICAL RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Nanoengineered Ink for Designing 3D Printable Flexible Bioelectronics

Kaivalya A. Deo et al.

Summary: A shear-thinning hydrogel has been developed as a biomaterial ink for 3D printing flexible bioelectronics. This hydrogel exhibits high conductivity, compressive modulus, and biocompatibility, and can be printed into complex shapes. The results suggest that this nanoengineered hydrogel holds great potential for various biomedical applications.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Clickable Organic Electrochemical Transistors

Gonzalo E. Fenoy et al.

Summary: This article presents the synthesis and characterization of clickable organic electrochemical transistors (OECTs) and demonstrates their applications in the interface of biological elements and biosensors. By clicking specific molecules onto the transistor surface, efficient binding with proteins and enzymes is achieved. The clicked OECTs maintain their stability and electronic features after the clicking reactions.

JACS AU (2022)

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Article Chemistry, Analytical

Addressing Cu2+ interference for accurate aptamer-based biomarker determinations of Alzheimer's disease

Xiaoli Cheng et al.

Summary: This study investigated the interference of Cu2+ in the interaction between A beta(40) oligomer (A beta O-40) and its aptamer (Apt) using surface plasmon resonance spectroscopy. The results showed that Cu2+ binding to Apt resulted in changes to its structure and affinity for A beta O-40. Real sample analysis revealed significant errors caused by Cu2+ in cerebrospinal fluid (CSF) and serum analysis. Further studies demonstrated that EDTA can eliminate the interference of Cu2+ on the A beta O-40/Apt system.

ANALYTICAL SCIENCES (2022)

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Article Biophysics

Hairpin DNA assisted dual-ratiometric electrochemical aptasensor with high reliability and anti-interference ability for simultaneous detection of aflatoxin B1 and ochratoxin A

Chengxi Zhu et al.

Summary: This work developed a dual-ratiometric electrochemical aptasensing strategy for simultaneous detection of AFB1 and OTA, showcasing a novel way for fabricating a high-performance aptasensor.

BIOSENSORS & BIOELECTRONICS (2021)

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Review Chemistry, Multidisciplinary

DNA-Encoded Chemistry: Drug Discovery from a Few Good Reactions

Patrick R. Fitzgerald et al.

Summary: Click chemistry and DNA-encoded library (DEL) technology share many similarities in their design and deployment in combinatorial chemistry, providing frameworks for the development of new synthesis methods to drive next-generation drug discovery.

CHEMICAL REVIEWS (2021)

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Article Chemistry, Analytical

Sequence-Independent DNA Adsorption on Few-Layered Oxygen-Functionalized Graphene Electrodes: An Electrochemical Study for Biosensing Application

Narges Asefifeyzabadi et al.

Summary: DNA adsorption on oxidized graphene surfaces significantly enhances electrochemical charge transfer, leading to amplified current response from redox probes. Inkjet-printed GO(x) electrodes show promise in fabricating highly sensitive platforms for label-free and chemisorption-free DNA biosensing applications.

BIOSENSORS-BASEL (2021)

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Article Chemistry, Multidisciplinary

A Wearable Optical Microfibrous Biomaterial with Encapsulated Nanosensors Enables Wireless Monitoring of Oxidative Stress

Mohammad Moein Safaee et al.

Summary: The use of optical core-shell microfibrous textiles incorporating single-walled carbon nanotubes enables real-time optical monitoring of hydrogen peroxide concentrations in wounds, maintaining structural integrity for at least 21 days. The nanosensors provide stable continuous analyte monitoring, making them a potential tool for wound treatment.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Sensing of COVID-19 Antibodies in Seconds via Aerosol Jet Nanoprinted Reduced-Graphene-Oxide-Coated 3D Electrodes

Md Azahar Ali et al.

Summary: This study presents an advanced biosensing platform based on nanomaterials for rapid detection of COVID-19 antibodies. By combining 3D nanoprinting technology and nanoflakes of reduced-graphene-oxide, it achieves fast and sensitive detection of antibodies, with potential for biomarker detection in other infectious diseases.

ADVANCED MATERIALS (2021)

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Review Chemistry, Applied

Alginate modification via click chemistry for biomedical applications

Yaling Deng et al.

Summary: This article reviews the use of click chemistry to modify alginate, enhancing its physical and chemical properties for various applications. Click chemistry can be employed to modify the mechanical strength and biochemical properties of alginate-based materials. The future perspectives of alginates modified with click chemistry are also discussed.

CARBOHYDRATE POLYMERS (2021)

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Review Chemistry, Multidisciplinary

Catalytic Nanomaterials toward Atomic Levels for Biomedical Applications: From Metal Clusters to Single-Atom Catalysts

Yu Fan et al.

Summary: Single-atom catalysts (SACs) have emerged as a frontier in the catalytic field due to their advantages in metal utilization, catalytic activity, selectivity, and stability, with increasing interests in applying them in biomedical fields. Precision engineering the structure and active site towards atomic levels is a trend for nanomedicines, promoting the evolution of metal-based biomedical nanomaterials from nanoparticles to clusters and now to SACs.

ACS NANO (2021)

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Article Chemistry, Analytical

Bioinspired Artificial Clickase for the Catalytic Click Immunoassay of Foodborne Pathogens

Xianlong Zhang et al.

Summary: A novel nanocatalyst containing stable Cu(I) inspired by natural multicopper oxidases (MCOs) was developed for CuAAC-based assays, showing superior properties in stability and catalytic activity. The use of CCN clickases as labels in a catalytic click fluorescence immunoassay for foodborne pathogens demonstrated high analytical performances with a low limit of detection, indicating great potential in foodborne pathogen detection.

ANALYTICAL CHEMISTRY (2021)

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Article Biophysics

Controllable design of a nano-bio aptasensing interface based on tetrahedral framework nucleic acids in an integrated microfluidic platform

Fulin Zhu et al.

Summary: This study investigates the self-assembling of tetrahedral framework nucleic acids in microfluidic devices, creating a three-dimensional reaction space at nanoscale and improving reaction kinetics during molecular recognition. The novel FNA-engineered microfluidic interface enables a one-stop assay of E. coli O157:H7 with high bacterial detection efficiency, selectivity, and precision. The application of the FNA interface shows promising potential for developing microfluidic biosensors for other pathogenic microorganisms or circulating tumor cells by changing the aptamers.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Multidisciplinary Sciences

De novo design of modular and tunable protein biosensors

Alfredo Quijano-Rubio et al.

Summary: Protein switches have been repurposed for biosensor development by inverting the flow of information, creating modular molecular devices with a closed dark state and an open luminescent state. These sensors, based on thermodynamic coupling, require only one target binding domain for direct readout in solution, allowing for the detection of various molecules clinically, including the SARS-CoV-2 spike protein with high sensitivity and a 50-fold higher luminescence signal than background level. The modularity and sensitivity of this platform enable rapid sensor construction for a wide range of analytes, demonstrating the power of de novo protein design in creating multi-state protein systems with new functions.

NATURE (2021)

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Article Chemistry, Multidisciplinary

Fabrication of Gradient and Patterned Organic Thin Films by Bipolar Electrolytic Micelle Disruption Using Redox-Active Surfactants

Yaqian Zhou et al.

Summary: Bipolar electrolytic micelle disruption (BEMD) system utilizes the advantageous potential distribution on bipolar electrodes to prepare gradient-thin organic films with various interesting compounds. The gradient feature was characterized by UV-Vis absorption, thickness measurements, and surface morphology analysis, and corresponding patterned films were successfully fabricated. This facile BEMD approach opens a long-term perspective for organic film preparation.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Chemistry, Analytical

Application of Functionalized Graphene Oxide Based Biosensors for Health Monitoring: Simple Graphene Derivatives to 3D Printed Platforms

Agnivo Gosai et al.

Summary: Biosensors have the potential to transform personalized medicine and environmental monitoring, with functional graphene being a popular choice for sensing material due to its ease of synthesis, high functionality, and large surface area for sensitive applications. The review highlights the current state-of-the-art biosensors based on graphene, emphasizing on the mechanism of sensing and future prospects in healthcare and environmental monitoring, particularly in additive manufacturing technologies like 3D printing.

BIOSENSORS-BASEL (2021)

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Review Chemistry, Multidisciplinary

Rational Design of Electrochemiluminescent Devices

Xiangui Ma et al.

Summary: Electrochemiluminescence (ECL) combines electrochemical and chemiluminescent methods, used in clinical analysis and biological research. Efforts focus on enhancing sensitivity, portability, and affordability of ECL devices. The research aims to develop new electrodes, wireless power transfer (WPT) based devices, and novel bipolar electrochemistry.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

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Review Nanoscience & Nanotechnology

Three-Dimensional (3D) Laser-Induced Graphene: Structure, Properties, and Application to Chemical Sensing

Federico Maria Vivaldi et al.

Summary: Graphene, despite being relatively new, has shown great potential in various fields such as chemical and biosensors. Laser-induced graphene (LIG), as a 3D porous material produced by direct laser scribing of carbonaceous precursors, has a high surface-to-volume ratio making it ideal for sensors relying on surface and interface phenomena.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Analytical

Signal Amplification Strategy Using Atomically Gold-Supported VO2 Nanobelts as a Co-reaction Accelerator for Ultrasensitive Electrochemiluminescent Sensor Construction Based on the Resonance Energy Transfer Platform

Jinna Guo et al.

Summary: In this study, gold-supported two-dimensional VO2 nanobelts were developed as co-reaction promoters to enhance the efficiency of luminol ECL emission for sensitive detection of GSH. The ECL sensor showed outstanding performance in real human serum samples, highlighting the potential for high-performance co-reaction accelerators using the ECL technique.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

An antifouling electrochemical biosensor based on a protein imprinted hydrogel for human immunoglobulin G recognition in complex biological media

Min Cui et al.

Summary: A specific and long-term antifouling biosensor interface was constructed based on a protein imprinted hydrogel for sensitive analysis of human immunoglobulin G (IgG) in complex biological media. The biosensor showed high sensitivity and selectivity in quantifying target IgG in complex biological samples, with a response range of 0.5 - 200.0 ng/mL and a limit of detection of 0.03 ng/mL (S/N = 3).

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

A self-driven PET chip-based imprinted electrochemical sensor for the fast detection of Salmonella

Hui Jiang et al.

Summary: The portable imprinted electrochemical sensor developed in this study utilizes a self-driven PET chip for fast detection of Salmonella, demonstrating high selectivity and sensitivity. It has the potential to be widely used in monitoring and controlling Salmonella contamination in food processing and circulation.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Review Chemistry, Multidisciplinary

Small-molecule fluorescence-based probes for interrogating major organ diseases

Hai-Hao Han et al.

Summary: This tutorial review discusses the importance of chemical tools in real-time monitoring of organ function and visualization of organ-related processes at the cellular level in biological research. It highlights the potential of small-molecule fluorescent probes in advancing the understanding of organ-related diseases and emphasizes the need for probes with high sensitivity, low limit of detection, fast response times, and appropriate biocompatibility.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Materials Science, Biomaterials

A comprehensive review on the applications of nano-biosensor-based approaches for non-communicable and communicable disease detection

Rout George Kerry et al.

Summary: Biosensors are attracting scientific communities due to their versatile applications in various domains, with the ability to detect biological components and generate detectable signals, offering exceptional sensitivity and flexibility in biosensing. This technology plays a crucial role in early detection and treatment of both communicable and non-communicable diseases.

BIOMATERIALS SCIENCE (2021)

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Review Chemistry, Analytical

Recent Progress in Electrochemiluminescence Sensing and Imaging

Cheng Ma et al.

ANALYTICAL CHEMISTRY (2020)

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In Situ Reduction of Porous Copper Metal-Organic Frameworks for Three-Dimensional Catalytic Click Immunoassay

Lan Xue et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

Immobilization and Function of nIR-Fluorescent Carbon Nanotube Sensors on Paper Substrates for Fluidic Manipulation

Daniel P. Salem et al.

ANALYTICAL CHEMISTRY (2020)

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DNAzyme-Triggered Visual and Ratiometric Electrochemiluminescence Dual-Readout Assay for Pb(II) Based on an Assembled Paper Device

Yan Zhang et al.

ANALYTICAL CHEMISTRY (2020)

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Preparation of Gas-Responsive Imprinting Hydrogel and Their Gas-Driven Switchable Affinity for Target Protein Recognition

Yubo Wei et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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DNA framework-engineered electrochemical biosensors

Fan Li et al.

SCIENCE CHINA-LIFE SCIENCES (2020)

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Nanobiosensing with graphene and carbon quantum dots: Recent advances

Brandon K. Walther et al.

MATERIALS TODAY (2020)

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DNA Hydrogel-Based Three-Dimensional Electron Transporter and Its Application in Electrochemical Biosensing

Xiaoxia Mao et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Highly sensitive detection of carcinoembryonic antigen using copper-free click chemistry on the surface of azide cofunctionalized graphene oxide

Wenwen Xiang et al.

ANALYTICA CHIMICA ACTA (2020)

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Design of electrochemical immunosensors using electro-click chemistry. Application to the detection of IL-1β cytokine in saliva

S. Guerrero et al.

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Tunable 3D nanofibrous and bio-functionalised PEDOT network explored as a conducting polymer-based biosensor

Lingyin Meng et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Highly sensitive and selective colorimetric sensor for thiocyanate based on electrochemical oxidation-assisted complexation reaction with Gold nanostars etching

Xinwen Cui et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Electrochemical Analysis of Target-Induced Hairpin-Mediated Aptamer Sensors

Shao Su et al.

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A Carbon-Based DNA Framework Nano-Bio Interface for Biosensing with High Sensitivity and a High Signal-to-Noise Ratio

Jing Su et al.

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Covalent and Noncovalent Functionalization of Graphene Oxide with DNA for Smart Sensing

Anand Lopez et al.

ADVANCED INTELLIGENT SYSTEMS (2020)

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Recent advance in biosensing applications based on two-dimensional transition metal oxide nanomaterials

Yongmei Jia et al.

TALANTA (2020)

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Real-time detection of wound-induced H2O2 signalling waves in plants with optical nanosensors

Tedrick Thomas Salim Lew et al.

NATURE PLANTS (2020)

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Click chemistry-assisted antibodies immobilization for immunosensing of CXCL7 chemokine in serum

Sara Guerrero et al.

JOURNAL OF ELECTROANALYTICAL CHEMISTRY (2019)

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Review Chemistry, Analytical

Copper(I)-Catalyzed Click Chemistry as a Tool for the Functionalization of Nanomaterials and the Preparation of Electrochemical (Bio)Sensors

P. Yanez-Sedeno et al.

SENSORS (2019)

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A self-powered wearable sweat-evaporation-biosensing analyzer for building sports big data

Hongye Guan et al.

NANO ENERGY (2019)

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DNA-SWCNT Biosensors Allow Real-Time Monitoring of Therapeutic Responses in Pancreatic Ductal Adenocarcinoma

Santanu Bhattacharya et al.

CANCER RESEARCH (2019)

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An in Vivo Nanosensor Measures Compartmental Doxorubicin Exposure

Jackson D. Harvey et al.

NANO LETTERS (2019)

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Bipolar Electrochemistry: A Powerful Tool for Electrifying Functional Material Synthesis

Naoki Shida et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Article Electrochemistry

Simultaneous Electro-Click and Electrochemically Mediated Polymerization Reactions for One-Pot Grafting from a Controlled Density of Anchor Sites

Ting Wu et al.

CHEMELECTROCHEM (2019)

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Article Nanoscience & Nanotechnology

Aptamer-Based Fluorescent Biosensing of Adenosine Triphosphate and Cytochrome c via Aggregation-Induced Emission Enhancement on Novel Label-Free DNA-Capped Silver Nanoclusters/Graphene Oxide Nanohybrids

Mojtaba Shamsipur et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Azulene-Derived Fluorescent Probe for Bioimaging: Detection of Reactive Oxygen and Nitrogen Species by Two-Photon Microscopy

Lloyd C. Murfin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Graphene oxide and enzyme-assisted dual-cycling amplification method for sensitive fluorometric determination of DNA

Idorenyin Iwe et al.

MICROCHIMICA ACTA (2019)

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Co3O4 nanoparticles supported mesoporous carbon framework interface for glucose biosensing

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TALANTA (2019)

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2D MoS2-Based Nanomaterials for Therapeutic, Bioimaging, and Biosensing Applications

Varnika Yadav et al.

SMALL (2019)

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Engineering electrochemical interface for biomolecular sensing

Min Li et al.

CURRENT OPINION IN ELECTROCHEMISTRY (2019)

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An Alternative Medical Diagnosis Method: Biosensors for Virus Detection

Yeseren Saylan et al.

BIOSENSORS-BASEL (2019)

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Biomedical applications of copper-free click chemistry: in vitro, in vivo, and ex vivo

Eunha Kim et al.

CHEMICAL SCIENCE (2019)

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Three-Dimensional Porous Ti3C2Tx MXene-Graphene Hybrid Films for Glucose Biosensing

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Au-Luminol-decorated porous carbon nanospheres for the electrochemiluminescence biosensing of MUC1

Jing-Wen Gao et al.

NANOSCALE (2019)

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Design synthesis of a controllable flower-like Pt-graphene oxide architecture through electrostatic self-assembly for DNA damage biomarker 8-hydroxy-2'-deoxyguanosine biosensing research

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Electrochemical assay for continuous monitoring of dynamic DNA methylation process

Li Zhang et al.

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Controlled decoration of boron-doped diamond electrodes by electrochemical click reaction (e-CLICK)

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CARBON (2018)

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Low symmetric metallophthalocyanine modified electrode via click chemistry for simultaneous detection of heavy metals

Gertrude Fomo et al.

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Conformationally Induced Off-On Cell Membrane Chemosensor Targeting Receptor Protein-Tyrosine Kinases for in Vivo and in Vitro Fluorescence Imaging of Cancers

Yang Jiao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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A Mitochondria-Specific Fluorescent Probe for Visualizing Endogenous Hydrogen Cyanide Fluctuations in Neurons

Lingliang Long et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Article Chemistry, Physical

Electro-click construction of hybrid nanocapsule films with triggered delivery properties

Flavien Sciortino et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2018)

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Article Chemistry, Analytical

Plasmonic Cu2-xSySe1-y Nanoparticles Catalyzed Click Chemistry Reaction for SERS Immunoassay of Cancer Biomarker

Lin Yang et al.

ANALYTICAL CHEMISTRY (2018)

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Review Biotechnology & Applied Microbiology

Recent advances in graphene-based biosensor technology with applications in life sciences

Janire Pena-Bahamonde et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

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Article Nanoscience & Nanotechnology

Click Chemistry: A Versatile Method for Tuning the Composition of Mixed Organic Layers Obtained by Reduction of Diazonium Cations

Marius Cesbron et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Review Chemistry, Physical

Graphene-based bioelectrochemistry and bioelectronics: A concept for the future?

Sabine Szunerits et al.

CURRENT OPINION IN ELECTROCHEMISTRY (2018)

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Article Chemistry, Multidisciplinary

Longitudinally Controlled Modification of Cylindrical and Conical Track-Etched Poly(ethylene terephthalate) Pores Using an Electrochemically Assisted Click Reaction

Herman Coceancigh et al.

LANGMUIR (2017)

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Review Polymer Science

Electrochemically mediated atom transfer radical polymerization (eATRP)

Pawel Chmielarz et al.

PROGRESS IN POLYMER SCIENCE (2017)

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Article Electrochemistry

Specific Picomolar Detection of a Breast Cancer Biomarker HER-2/neu Protein in Serum: Electrocatalytically Amplified Electroanalysis by the Aptamer/PEG-Modified Electrode

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CHEMELECTROCHEM (2017)

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Article Chemistry, Analytical

Cucurbituril and Azide Cofunctionalized Graphene Oxide for Ultrasensitive Electro-Click Biosensing

Tianxiang Wei et al.

ANALYTICAL CHEMISTRY (2017)

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Article Nanoscience & Nanotechnology

Introducing Ratiometric Fluorescence to MnO2 Nanosheet-Based Biosensing: A Simple, Label-Free Ratiometric Fluorescent Sensor Programmed by Cascade Logic Circuit for Ultrasensitive GSH Detection

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ACS APPLIED MATERIALS & INTERFACES (2017)

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Review Chemistry, Multidisciplinary

Metal Sensing by DNA

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CHEMICAL REVIEWS (2017)

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Article Biochemical Research Methods

Capacitive DNA sensor for rapid and sensitive detection of whole genome human herpesvirus-1 dsDNA in serum

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ELECTROPHORESIS (2017)

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DNA Modified Fe3O4@Au Magnetic Nanoparticles as Selective Probes for Simultaneous Detection of Heavy Metal Ions

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Electrochemical Immunoassays Based on Graphene: A Review

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ELECTROANALYSIS (2016)

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Multiplexed site-specific electrode functionalization for multitarget biosensors

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BIOELECTROCHEMISTRY (2016)

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Review Chemistry, Multidisciplinary

Noncovalent Functionalization of Graphene and Graphene Oxide for Energy Materials, Biosensing, Catalytic, and Biomedical Applications

Vasilios Georgakilas et al.

CHEMICAL REVIEWS (2016)

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Review Chemistry, Multidisciplinary

Recent development of carbon electrode materials and their bioanalytical and environmental applications

Wei Zhang et al.

CHEMICAL SOCIETY REVIEWS (2016)

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Review Chemistry, Physical

DNA adsorbed on graphene and graphene oxide: Fundamental interactions, desorption and applications

Biwu Liu et al.

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE (2016)

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Real-Time Tracking and In Vivo Visualization of β-Galactosidase Activity in Colorectal Tumor with a Ratiometric Near-Infrared Fluorescent Probe

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FRET-Based Mito-Specific Fluorescent Probe for Ratiometric Detection and Imaging of Endogenous Peroxynitrite: Dyad of Cy3 and Cy5

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Palladium Nanoparticles Embedded in a Layer-by-Layer Nanoreactor Built with Poly(Acrylic Acid) Using Electro-Click Chemistry

Matias Villalba et al.

LANGMUIR (2016)

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Review Chemistry, Analytical

Viral protein-based bioanalytical tools for small RNA biosensing

Susana Campuzano et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2016)

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Single near-infrared fluorescent probe with high- and low-sensitivity sites for sensing different concentration ranges of biological thiols with distinct modes of fluorescence signals

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CHEMICAL SCIENCE (2016)

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Article Chemistry, Organic

Functionalized branched EDOT-terthiophene copolymer films by electropolymerization and post-polymerization click-reactions

Miriam Goll et al.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2015)

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Review Chemistry, Multidisciplinary

Electrochemical Synthesis of Photoelectrodes and Catalysts for Use in Solar Water Splitting

Donghyeon Kang et al.

CHEMICAL REVIEWS (2015)

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Article Electrochemistry

Electroassisted click chemistry immobilisation of gold nanoparticles on a solid substrate

Adam Lesniewski et al.

ELECTROCHEMISTRY COMMUNICATIONS (2015)

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Review Chemistry, Multidisciplinary

Electrochemical nanoarchitectonics and layer-by-layer assembly: From basics to future

Gaulthier Rydzek et al.

NANO TODAY (2015)

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Synthesis of electroconductive hydrogel films by an electro-controlled click reaction and their application to drug delivery systems

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Review Polymer Science

Recent advances in the synthesis and applications of graphene-polymer nanocomposites

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POLYMER CHEMISTRY (2015)

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Selective Nanotrench Filling by One-Pot Electroclick Self-Constructed Nanoparticle Films

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Review Physics, Condensed Matter

Graphene oxide: from fundamentals to applications

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Simultaneous Electropolymerization and Electro-Click Functionalization for Highly Versatile Surface Platforms

Gaulthier Rydzek et al.

ACS NANO (2014)

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Review Biophysics

Graphene oxide-DNA based sensors

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BIOSENSORS & BIOELECTRONICS (2014)

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A phosphomolybdic acid anion probe-based label-free, stable and simple electrochemical biosensing platform

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CHEMICAL COMMUNICATIONS (2014)

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A strong adsorbent for Cu2+: graphene oxide modified with triethanolamine

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Mechanism of antibacterial activity of copper nanoparticles

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NANOTECHNOLOGY (2014)

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Review Biotechnology & Applied Microbiology

Non-invasive wearable electrochemical sensors: a review

Amay J. Bandodkar et al.

TRENDS IN BIOTECHNOLOGY (2014)

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Biocompatible click chemistry enabled compartment-specific pH measurement inside E-coli

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NATURE COMMUNICATIONS (2014)

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Electrical signal guided click coating of chitosan hydrogel on conductive surface

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Reactive self-assembled monolayers: from surface functionalization to gradient formation

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Double electrochemical covalent coupling method based on click chemistry and diazonium chemistry for the fabrication of sensitive amperometric immunosensor

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ANALYTICA CHIMICA ACTA (2013)

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Review Chemistry, Multidisciplinary

Bipolar Electrochemistry

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

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Review Chemistry, Multidisciplinary

Light-Induced Click Reactions

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

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A New Trend on Biosensor for Neurotransmitter Choline/Acetylcholine-an Overview

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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2013)

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Impedimetric biosensor based on cell-mediated bioimprinted films for bacterial detection

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BIOSENSORS & BIOELECTRONICS (2013)

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Fast Assembling of Magnetic Iron Oxide Nanoparticles by Microwave-Assisted Copper(I) Catalyzed Alkyne-Azide Cycloaddition (CuAAC)

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CHEMISTRY OF MATERIALS (2013)

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Surface patterning using scanning electrochemical microscopy to locally trigger a click chemistry reaction

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ELECTROCHEMISTRY COMMUNICATIONS (2013)

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A self-referenced nanodosimeter for reaction based ratiometric imaging of hypochlorous acid in living cells

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CHEMICAL SCIENCE (2013)

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Reactivity mapping with electrochemical gradients for monitoring reactivity at surfaces in space and time

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NATURE COMMUNICATIONS (2013)

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Shape-controlled fabrication of micron-scale surface chemical gradients via electrochemically activated copper(I) click chemistry

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JOURNAL OF MATERIALS CHEMISTRY B (2013)

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Review Biotechnology & Applied Microbiology

Immobilization strategies to develop enzymatic biosensors

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Electrografted nanostructured platforms for click chemistry

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ELECTROCHEMISTRY COMMUNICATIONS (2012)

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Morphogen-driven self-construction of covalent films built from polyelectrolytes and homobifunctional spacers: buildup and pH response

Gaulthier Rydzek et al.

SOFT MATTER (2012)

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Review Biology

Gradient biomaterials and their influences on cell migration

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INTERFACE FOCUS (2012)

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Article Polymer Science

Electro-Click Modification of Conducting Polymer Surface Using Cu(I) Species Generated on a Bipolar Electrode in a Gradient Manner

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ACS MACRO LETTERS (2012)

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Article Chemistry, Multidisciplinary

Electrochemically Triggered Assembly of Films: A One-Pot Morphogen-Driven Buildup

Gaulthier Rydzek et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

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Review Engineering, Biomedical

Electroconductive hydrogels: Synthesis, characterization and biomedical applications

Anthony Guiseppi-Elie

BIOMATERIALS (2010)

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Review Chemistry, Multidisciplinary

Copper-catalyzed azide-alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper(I) acetylides

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CHEMICAL SOCIETY REVIEWS (2010)

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Article Biochemical Research Methods

Alkyne-azide click reaction catalyzed by metallic copper under ultrasound

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NATURE PROTOCOLS (2010)

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Cellular biosensor based on red blood cells immobilized on Fe3O4 Core/Au Shell nanoparticles for hydrogen peroxide electroanalysis

Chao Chen et al.

MICROCHIMICA ACTA (2010)

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Article Chemistry, Physical

Exploring the versatility of hydrogels derived from living organocatalytic ring-opening polymerization

Fredrik Nederberg et al.

SOFT MATTER (2010)

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Spatially Selective Functionalization of Conducting Polymers by Electroclick Chemistry

Thomas Steen Hansen et al.

ADVANCED MATERIALS (2009)

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Article Biochemistry & Molecular Biology

Protein Design Provides Lead(II) Ion Biosensors for Imaging Molecular Fluxes around Red Blood Cells

Vivekanand S. Shete et al.

BIOCHEMISTRY (2009)

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Article Chemistry, Multidisciplinary

Copper-free azide-alkyne cycloadditions: New insights and perspectives

Jean-Francois Lutz

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)

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Article Chemistry, Multidisciplinary

Surface patterning with fluorescent molecules using click chemistry directed by scanning electrochemical microscopy

Sung-Yu Ku et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

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Review Chemistry, Multidisciplinary

Surface-bound soft matter gradients

Jan Genzer et al.

LANGMUIR (2008)

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Article Chemistry, Multidisciplinary

Ligand-accelerated Cu-catalyzed azide-alkyne cycloaddition:: A mechanistic report

Valentin O. Rodionov et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

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Article Chemistry, Multidisciplinary

Selective functionalization of independently addressed microelectrodes by electrochemical activation and deactivation of a coupling catalyst

NK Devaraj et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)

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Article Chemistry, Analytical

Reference electrode for ionic liquids

A Saheb et al.

ELECTROANALYSIS (2006)

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Article Electrochemistry

Nanostructuring electrodes with carbon nanotubes: A review on electrochemistry and applications for sensing

JJ Gooding

ELECTROCHIMICA ACTA (2005)

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Article Chemistry, Organic

Polytriazoles as copper(I)-stabilizing ligands in catalysis

TR Chan et al.

ORGANIC LETTERS (2004)

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Article Chemistry, Multidisciplinary

A strain-promoted [3+2] azide-alkyne cycloaddition for covalent modification of blomolecules in living systems

NJ Agard et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)

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Using DNA-binding proteins as an analytical tool

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)

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