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SERS-Based Optical Nanobiosensors for the Detection of Alzheimer's Disease

BIOSENSORS-BASEL (2023)

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Article Chemistry, Analytical

Fascinating Immobilization-Free Electrochemical Immunosensing Strategy Based on the Cooperation of Buoyancy and Magnetism

Hui-Jing Pan et al.

Summary: This study proposes an advanced and robust strategy for immobilization-free electrochemical immunosensing by integrating buoyant recognition probe with magnetic reporter probe in one solution. The strategy exhibited a wide linear range, low detection limit, and good reproducibility, selectivity, and stability. This method offers advantages of simplicity, rapidness, and high sensitivity.

ANALYTICAL CHEMISTRY (2023)

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Review Pharmacology & Pharmacy

Alzheimer?s disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs

Ana R. Monteiro et al.

Summary: Alzheimer's disease is a prevalent neurodegenerative disease that affects millions of people worldwide. It is characterized by cognitive decline and degeneration of cholinergic neurons. The available therapies are limited, and the disease's pathogenesis is complex, involving the presence of neurofibrillary tangles and amyloid-beta peptide aggregates. Innovative multitarget therapeutical compounds are being developed to delay disease progression and restore cell function, and research on new insights and emerging disease-modifying drugs is ongoing.

BIOCHEMICAL PHARMACOLOGY (2023)

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Article Oncology

NK cell activity and methylated HOXA9 ctDNA as prognostic biomarkers in patients with non-small cell lung cancer treated with PD-1/PD-L1 inhibitors

Sara Witting Christensen Wen et al.

Summary: Natural killer cell activity (NKA) and methylated HOXA9 circulating tumor DNA (ctDNA) can serve as prognostic biomarkers in patients with non-small cell lung cancer (NSCLC) treated with PD-1/PD-L1 inhibitors. Evaluating the NKA and ctDNA status after one treatment cycle can accurately predict patient survival.

BRITISH JOURNAL OF CANCER (2023)

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Article Chemistry, Multidisciplinary

Single-platform, Attomolar Detection of Multiple Biomarkers by a Flexible SERS Sensor

Ankita Jaiswal et al.

Summary: In this study, a surface enhanced Raman spectroscopy (SERS) active sensor was developed for the sensitive and selective detection of beta-Amyloid Peptide (A beta(1-42)), a biomarker of Alzheimer's disease. The sensor was prepared by functionalizing polyacrylonitrile (PAN) nanofiber mats with silver nanoparticles (AgNPs). The P-3/AgNPs sensor showed the highest sensitivity and was used for the detection of A beta(1-42) and human Insulin (HI) with a low limit of detection (LoD). The selectivity of the sensor was demonstrated by its ability to identify A beta(1-42) peaks in a simulated cerebrospinal fluid (CSF).

CHEMISTRY-AN ASIAN JOURNAL (2023)

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Review Neurosciences

Advances and applications of fluids biomarkers in diagnosis and therapeutic targets of Alzheimer's disease

Yanan Xu et al.

Summary: Alzheimer's disease (AD) is a neurodegenerative disease that poses challenges in early diagnosis and effective treatment. Biomarkers in fluids, such as cerebrospinal fluid, blood, and saliva, hold potential for diagnosis and treatment. Research has mainly focused on biomarkers associated with AD mechanisms, such as amyloid-beta plaques and Tau protein abnormal phosphorylation.

CNS NEUROSCIENCE & THERAPEUTICS (2023)

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Review Neurosciences

miRNAs and Stem Cells as Promising Diagnostic and Therapeutic Targets for Alzheimer's Disease

Emad M. Elzayat et al.

Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by cognitive impairment, memory loss, and behavioral changes. The exact causes of AD are not fully understood, but amyloid-beta peptides and tau proteins are believed to play a role. Various demographic, genetic, and environmental risk factors contribute to the onset and progression of AD. MicroRNA levels show promise as a diagnostic tool for AD, and while there are currently only two FDA-approved therapeutic drugs, new approaches such as acitretin and stem cells show potential for treatment. This review highlights promising diagnostic techniques and therapeutic approaches for AD.

JOURNAL OF ALZHEIMERS DISEASE (2023)

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Review Radiology, Nuclear Medicine & Medical Imaging

Magnetic Resonance Elastography in the Study of Neurodegenerative Diseases

Yuan Feng et al.

Summary: Neurodegenerative diseases like AD and PD are a major health burden, but early diagnosis remains challenging. MRE, a noninvasive MRI technique, has been applied to study these diseases. Animal studies found decreased stiffness of the hippocampal region in AD mice, but results for disease progression varied. Clinical studies showed significant decreases in whole brain stiffness for both AD and PD, affecting different brain structures. MRE studies are in early stages, and further investigation is needed to understand the relationship between brain mechanical properties and clinical measures.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2023)

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Article Biochemical Research Methods

An approach for in-situ detection of gold colloid aggregates amyloid formations within the hippocampus of the Cohen's Alzheimer's disease rat model by surface enhanced raman scattering methods

Kazushige Yokoyama et al.

Summary: By using the Surface Enhanced Raman Scattering (SERS) method, researchers successfully detected gold colloid aggregates in the hippocampus of AD rats, which were found to contain amyloid fibrils. These aggregates had unique physical morphology compared to in-vitro A beta 1-40 or A beta 1-42 mediated gold colloid aggregates.

JOURNAL OF NEUROSCIENCE METHODS (2023)

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Article Chemistry, Physical

Ultrasensitive and point-of-care detection of plasma phosphorylated tau in Alzheimer's disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assay

Liding Zhang et al.

Summary: Phosphorylation of tau at Ser(396,404) is an early event in Alzheimer's disease (AD), and plasma p-tau(396,404) level could be a potential biomarker for AD. Researchers developed a dual-output lateral flow assay (LFA) that combines colorimetric and surface-enhanced Raman scattering (SERS) for the rapid, sensitive, and robust detection of plasma p-tau(396,404) levels. The LFA showed a detection limit of 60 pg/mL by the naked eye or 3.8 pg/mL by SERS, with no cross-reactivity with other tau species. This LFA could differentiate AD patients from healthy controls, suggesting its potential for point-of-care AD diagnosis.

NANO RESEARCH (2023)

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Article Chemistry, Multidisciplinary

Photonic-Plasmonic Coupling Enhanced Fluorescence Enabling Digital-Resolution Ultrasensitive Protein Detection

Priyash Barya et al.

Summary: Assays using fluorophores are common in life science research and diagnostics. However, weak emission intensity limits the detection limits, requiring a large number of labeled target molecules to improve signal-to-noise ratio. This study demonstrates that the synergistic coupling of plasmonic and photonic modes can significantly enhance the emission from fluorophores, resulting in a 52-fold improvement in signal intensity. The method is successfully applied to a sandwich immunoassay for human interleukin-6, achieving a detection limit three orders of magnitude lower than standard immunoassays.

SMALL (2023)

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Review Clinical Neurology

Deep Imaging to Dissect Microvascular Contributions to White Matter Degeneration in Rodent Models of Dementia

Stefan Stamenkovic et al.

Summary: The increasing socio-economic burden of Alzheimer disease (AD) and AD-related dementias has created a pressing need to define targets for therapeutic intervention. Animal models that recapitulate features of AD/AD-related dementias may provide mechanistic insight because microvascular pathology can be studied as it develops in vivo. Recent advances in in vivo optical and ultrasound-based imaging of the rodent brain facilitate this goal by providing access to deeper brain structures, including white matter and hippocampus, which are more vulnerable to injury during cerebrovascular disease.

STROKE (2023)

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Article Multidisciplinary Sciences

An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer's disease

Victor Lau et al.

Summary: Alzheimer's disease primarily involves neurodegeneration and cognitive decline, with progressive memory loss. Aging and other risk factors promote the accumulation of AD pathologies and inflammation. Glial senescence, particularly senescent microglia accumulation, contributes to the perpetuation of AD pathologies, glial aging, and further senescence. Increasing glial senescence is proposed to drive individuals from healthy cognition into cognitive decline and dementia.

NATURE COMMUNICATIONS (2023)

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Article Multidisciplinary Sciences

A novel Alzheimer's disease prognostic signature: identification and analysis of glutamine metabolism genes in immunogenicity and immunotherapy efficacy

Zixuan Wu et al.

Summary: This study discovered four glutamine metabolism genes (ATP5H, NDUFAB1, PFN2, and SPHKAP) that are linked to Alzheimer's disease (AD) and confirmed their diagnostic efficiency in identifying AD.

SCIENTIFIC REPORTS (2023)

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Review Biotechnology & Applied Microbiology

Recent development of surface-enhanced Raman scattering for biosensing

Chenglong Lin et al.

Summary: Surface-Enhanced Raman Scattering (SERS) technology has made substantial progress in various fields such as environmental science, medical diagnosis, food safety, and biological analysis. This article summarizes the recent developments of SERS substrates and their applications in biomolecular detection, biological imaging, and pesticide detection. Important strategies for improving SERS biosensing performance and the applications of machine learning methods and software acquisition sources in SERS biosensing and diagnosing are comprehensively discussed. The challenges and future perspectives of SERS biosensing are also presented.

JOURNAL OF NANOBIOTECHNOLOGY (2023)

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Article Immunology

Identification of core cuprotosis-correlated biomarkers in abdominal aortic aneurysm immune microenvironment based on bioinformatics

Jiateng Hu et al.

Summary: This study identified cuprotosis-related genes involved in the pathogenesis and progression of abdominal aortic aneurysms (AAAs) through high-throughput RNA sequencing. Gene ontology and KEGG pathway analysis revealed the involvement of these genes in various biological processes and pathways. Additionally, cuprotosis-related genes (NLRP3, FDX1) were found to be upregulated in AAA samples. These findings provide new insights into potential targets for AAA therapy.

FRONTIERS IN IMMUNOLOGY (2023)

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Article Public, Environmental & Occupational Health

Association between hearing aid use and all-cause and cause-specific dementia: an analysis of the UK Biobank cohort

Fan Jiang et al.

Summary: The use of hearing aids is associated with a similar risk of dementia in people with hearing loss as compared to those without. Hearing loss accounts for 29.6% of the attributable risk of dementia, and the association between hearing aid use and dementia is partially mediated by reducing social isolation, loneliness, and depressed mood.

LANCET PUBLIC HEALTH (2023)

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Article Biophysics

Colorimetric and surface-enhanced Raman scattering dual-mode magnetic immunosensor for ultrasensitive detection of blood phosphorylated tau in Alzheimer?s disease

Liding Zhang et al.

Summary: In this research, a dual-mode magnetic immunosensor was developed for highly sensitive and specific detection of p-tau396,404 in blood samples. The immunosensor showed promising potential for rapid clinical diagnosis and large-scale screening of Alzheimer's disease.

BIOSENSORS & BIOELECTRONICS (2023)

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Article Biochemistry & Molecular Biology

State of the Art of microRNAs Signatures as Biomarkers and Therapeutic Targets in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis

Idiberto José Zotarelli-Filho et al.

Biomedicines (2023)

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Review Chemistry, Analytical

Recent Progress of Surface-Enhanced Raman Spectroscopy for Bacteria Detection

Lulu Liu et al.

Summary: There are pathogenic bacteria in the living environment that pose a threat to human health and economic development. Conventional detection methods are time-consuming and labor-intensive. Surface-enhanced Raman spectroscopy (SERS) has emerged as a rapid and sensitive method for the detection and identification of bacteria.

BIOSENSORS-BASEL (2023)

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Review Chemistry, Analytical

Multiplex Detection of Infectious Diseases on Microfluidic Platforms

Fumin Chen et al.

Summary: Infectious diseases play a significant role in the global disease burden. Microfluidic technologies have emerged as promising alternatives to conventional methods for multiple detection of infectious diseases. This review presents recent advances in microfluidic platforms, including microfluidic immunosensors and microfluidic nucleic acid sensors, and discusses their potential in infectious disease detection.

BIOSENSORS-BASEL (2023)

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Review Biology

The Eye as a Diagnostic Tool for Alzheimer's Disease

Ahsan Hussain et al.

Summary: Alzheimer's disease is a progressive neurodegenerative disorder affecting cognitive function and behavior in the elderly. Early diagnosis and management in the preclinical stage can significantly improve patient outcomes. While the diagnosis of Alzheimer's disease currently relies on clinical methods supplemented by invasive biomarker testing, recent advancements have been made in understanding the role of ocular tissue as a potential biomarker. Ocular biomarkers offer the potential for noninvasive and accessible diagnostics and monitoring.

LIFE-BASEL (2023)

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Review Immunology

Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation

Yijun Chen et al.

Summary: Alzheimer's Disease (AD) is mostly responsible for dementia, characterized by neuritic plaques and neurofibrillary tangles containing aggregated β-amyloid (Aβ) and hyperphosphorylated tau protein. Recent focus has been on disease-modifying therapy targeting Aβ, although the efficacy and long-term safety of such drugs are still controversial. Tau has gained attention as a therapeutic target due to its association with cognitive dysfunction. Inflammation, especially neuroinflammation, is linked to AD and tau pathology. Understanding the relationship between tau pathology and neuroinflammation will contribute to discovering therapeutic targets for AD and other tau-related diseases.

JOURNAL OF NEUROINFLAMMATION (2023)

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Review Clinical Neurology

Anti-Amyloid Immunotherapies for Alzheimer's Disease: A 2023 Clinical Update

Golnaz Yadollahikhales et al.

Summary: The amyloid cascade hypothesis provides a framework for therapeutic development in Alzheimer's disease. Experimental therapies targeting amyloid beta have shown promise in reducing neurotoxic effects and brain burden. Recent trials have supported the clinical efficacy of third-generation anti-amyloid immunotherapies and led to FDA approval. However, these therapies have modest effects and associated risks, highlighting the need for further research. The progress in AD therapeutics presents challenges and opportunities for the field of neurology and dementia care.

NEUROTHERAPEUTICS (2023)

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Article Chemistry, Analytical

Construction of a microcavity-based microfluidic chip with simultaneous SERS quantification of dual biomarkers for early diagnosis of Alzheimer's disease

Jianli Sun et al.

Summary: Due to the lack of effective therapy for Alzheimer's disease (AD), early analysis of AD core biomarkers has become crucial in clinical diagnosis. In this study, we developed a microfluidic chip with an Au-plasmonic shell attached to polystyrene (PS) microspheres for simultaneous detection of A beta 1-42 and p-Tau181 protein using ultrasensitive surface enhanced Raman spectroscopy (SERS). The synergetic coupling between PS microcavity and localized surface plasmon resonance (LSPR) of AuNPs was demonstrated, resulting in highly amplified electromagnetic fields. The microfluidic system allowed for multiplex testing and quantitatively detected AD-related dual proteins with a low limit of 100 fg mL-1. This microcavity-based SERS strategy provides a new approach for accurate prediction of AD in human blood samples and has potential applications in general disease assays.

TALANTA (2023)

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Article Chemistry, Analytical

Quantitative detection of dopamine in human serum with surface-enhanced Raman scattering (SERS) of constrained vibrational mode

Yongheum Choi et al.

Summary: In this study, the quantitative detection of dopamine (DA) was achieved using the peak shift in surface-enhanced Raman scattering (SERS) of 4-mercaptophenylboronic acid (4-MPBA) as a result of DA concentration. Ag nanostructures were prepared using gas-flow sputtering, and 4-MPBA was introduced through vapor-based deposition to act as a reporter molecule for bonding with DA. The experimental results showed a gradual peak shift from 1075.6 cm-1 to 1084.7 cm-1 with increasing DA concentration.

TALANTA (2023)

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Article Geriatrics & Gerontology

Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s disease

Ahmed Noor Eddin et al.

Frontiers in Aging Neuroscience (2023)

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Article Cell Biology

Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies

Laia Montoliu-Gaya et al.

Summary: This study quantified six phosphorylated and two non-phosphorylated plasma tau peptides, and found that p-tau217, p-tau231 and p-tau205 are the plasma tau forms that best reflect AD-related brain changes, with distinct correlations with amyloid and tau pathologies and emergences along the AD continuum.

NATURE AGING (2023)

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Article Chemistry, Analytical

Highly sensitive surface-enhanced Raman scattering-based immunosensor incorporating half antibody-fragment for quantitative detection of Alzheimer's disease biomarker in blood

Su Ji Yang et al.

Summary: This study developed a sensor based on surface-enhanced Raman scattering (SERS) for the quantitative determination of tau protein in the plasma of AD patients. The sensor demonstrated ultra-sensitivity and specificity, enabling accurate detection of AD biomarkers and simple point-of-care testing in clinical diagnosis.

ANALYTICA CHIMICA ACTA (2022)

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Review Chemistry, Physical

Quantitative Surface-Enhanced Spectroscopy

Ryan D. Norton et al.

Summary: This review discusses the recent advances in quantitative SERS detection, focusing on intermolecular interactions, surface selection rules, and target molecule solubility and accessibility. The impacts of surface selection rules and enhancement mechanisms on the activation and deactivation of normal Raman modes in SERS are explored. The review also summarizes the experimental conditions that can be used to tune the molecular affinity to and density near SERS substrates.

ANNUAL REVIEW OF PHYSICAL CHEMISTRY (2022)

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Editorial Material Pharmacology & Pharmacy

Blood-Based Alzheimer's Biomarkers

[Anonymous]

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

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Article Medicine, Research & Experimental

SERS Tags for Biomedical Detection and Bioimaging

Huiqiao Liu et al.

Summary: Surface-enhanced Raman scattering (SERS) has become a valuable technique for molecular identification, with high sensitivity, excellent signal specificity, and photobleaching resistance. SERS tags, obtained by attaching organic molecules to plasmonic nanoparticles, show high-performance multiplexing capability for biosensing. In the past decade, SERS tags have made progress in liquid biopsy, bioimaging, and theranostics applications.

THERANOSTICS (2022)

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Review Immunology

The Impact of Systemic Inflammation on Alzheimer's Disease Pathology

Junhua Xie et al.

Summary: Alzheimer's disease is an age-related neurodegenerative disorder with increasing prevalence. Current treatments are limited to symptomatic medication, and there is a need for a better understanding of the underlying mechanisms to develop more rational therapies. Peripheral inflammation has been identified as a detrimental factor in AD, and this review provides an overview of the link between peripheral inflammation and AD initiation and progression, contributing to a broader understanding of the disease pathology.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Recent developments of droplets-based microfluidics for bacterial analysis

Ruizhi Ning et al.

Summary: Droplet-based microfluidics allows for the generation of uniform microdroplets at a small scale and precise control, providing a powerful tool for rapid, sensitive, and high-throughput detection and analysis of bacteria. The advantages include isolation and manipulation of single cells, improved effective concentrations, elimination of heterogeneous population effects, and reduced contamination risks. It has great potential in biological medicine, microbiological engineering, and environmental ecology.

CHINESE CHEMICAL LETTERS (2022)

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Review Neurosciences

TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

Rui-Yang Li et al.

Summary: TREM2 is an important immune receptor that can impact lipid metabolism in both the central nervous system and the periphery, and may have implications for the pathogenesis of AD. Through pathways including inflammation, insulin resistance, and AD pathology, the association between TREM2 and AD may be mediated by altered lipid metabolism.

MOLECULAR NEURODEGENERATION (2022)

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Review Biochemistry & Molecular Biology

Development of Alzheimer's Disease Biomarkers: From CSF- to Blood-Based Biomarkers

Sakulrat Mankhong et al.

Summary: This article reviews the discovery and development of biomarkers for Alzheimer's disease (AD), discussing the use of cerebrospinal fluid (CSF) and blood-based biomarkers. The proposed ATN scheme may provide a common language for researchers studying AD. Blood-based biomarkers offer a promising alternative to CSF biomarkers.

BIOMEDICINES (2022)

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Article Clinical Neurology

Alzheimer's Disease: Epidemiology and Clinical Progression

Amir Abbas Tahami Monfared et al.

Summary: Alzheimer's disease is a leading cause of dementia in older individuals worldwide. The prevalence, incidence, and mortality of AD are increasing, highlighting the need for a better understanding of its epidemiology and progression. Risk factors for AD dementia include biomarkers, neurodegeneration, and being female. As new disease-modifying therapies emerge, the use of biomarkers alongside neurocognitive tests will play a crucial role in clinical practice.

NEUROLOGY AND THERAPY (2022)

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Article Chemistry, Analytical

Characterization of Bacteria Using Surface-Enhanced Raman Spectroscopy (SERS): Influence of Microbiological Factors on the SERS Spectra

Danielle M. Allen et al.

Summary: Although SERS is a rapid method for identifying bacteria, variation in experimental procedures can lead to considerable spectral variation. Mixing bacteria with CRSC and drying the suspension can generate highly reproducible spectra. These observations are important for the clinical applications of SERS as they highlight the challenges that need to be addressed.

ANALYTICAL CHEMISTRY (2022)

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Article Geriatrics & Gerontology

Heart fatty acid-binding protein is associated with phosphorylated tau and longitudinal cognitive changes

Yan Fu et al.

Summary: HFABP is significantly associated with the longitudinal cognitive changes in Alzheimer's disease, which may be partially mediated by tau pathology.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Review Chemistry, Multidisciplinary

Application of SERS in the Detection of Fungi, Bacteria and Viruses

Jiarui Xia et al.

Summary: This review highlights the recent advances of SERS in the study of fungi, bacteria, and viruses. It discusses the advantages of SERS over fluorescence in the identification and detection of viruses. It also explores the feasibility of using Raman/SERS spectrum analysis and various nanostructured substrates for the identification and detection of fungi. Additionally, it focuses on the application of SERS spectra in nucleic acid analysis and pathogen detection, as well as the development of SERS-based microdevices.

NANOMATERIALS (2022)

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Review Chemistry, Analytical

Recent Progress on Solid Substrates for Surface-Enhanced Raman Spectroscopy Analysis

Kun Ge et al.

Summary: Surface-enhanced Raman spectroscopy (SERS) is a powerful technique used for analysis and sensors. This review focuses on the recent advances in solid SERS substrates, including their fabrication methods, categories, and applications. The solid SERS substrates are preferred due to their dense hot spot, high stability, and controllable morphology. The review provides a detailed introduction to the different categories and construction strategies of solid SERS substrates, and briefly summarizes their typical applications in bio-analysis, food safety analysis, and environmental analysis. Furthermore, the challenges and perspectives of solid SERS substrates are discussed, including improving analytical performance and enhancing large-scale production levels.

BIOSENSORS-BASEL (2022)

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Review Cell Biology

Emerging blood exosome-based biomarkers for preclinical and clinical Alzheimer's disease: a meta-analysis and systematic review

Wei-Lin Liu et al.

Summary: Blood exosomes, extracellular vesicles secreted by living cells, can be used as a noninvasive tool for monitoring brain physiology and diseases. A meta-analysis and systematic review of blood exosome biomarkers in preclinical Alzheimer's disease, mild cognitive impairment, and Alzheimer's disease revealed increased levels of core biomarkers and other molecules related to risk factors. These findings support the development of exosome biomarkers for clinical blood tests for Alzheimer's disease.

NEURAL REGENERATION RESEARCH (2022)

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Article Chemistry, Analytical

Ultrasensitive detection of multiple Alzheimer's disease biomarkers by SERS-LFA

Yuanbao Zhan et al.

Summary: Alzheimer's disease is a major public health crisis, and early diagnosis and intervention are crucial. Detecting multiple AD biomarkers in blood is important, and the SERS-LFA technique offers high sensitivity and specificity for sensitive detection.

ANALYST (2022)

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Article Medicine, General & Internal

YKL-40 as a Potential Biomarker for the Differential Diagnosis of Alzheimer's Disease

Ioannis Mavroudis et al.

Summary: Alzheimer's disease is a neurodegenerative disorder associated with inflammation. Elevated YKL-40 levels in the cerebrospinal fluid may serve as a biomarker for the diagnosis and management of AD.

MEDICINA-LITHUANIA (2022)

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Review Clinical Neurology

Blood-based biomarkers for Alzheimer's disease: towards clinical implementation

Charlotte E. Teunissen et al.

Summary: Recent research suggests that blood-based biomarkers for Alzheimer's disease may become a reality, with consistent results across different cohorts. Additionally, other blood-based biomarkers can provide information about disease progression and treatment effects.

LANCET NEUROLOGY (2022)

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Article Cell Biology

Diagnostic accuracy of blood biomarkers for Alzheimer's disease and amnestic mild cognitive impairment: A meta-analysis

Ying-Ren Chen et al.

Summary: Blood-based biomarkers have shown high diagnostic accuracy for detecting Alzheimer's disease, with plasma A beta 42, A beta oligomer, and plasma tau demonstrating good sensitivity and specificity. However, evidence for detecting amnestic mild cognitive impairment using blood-based biomarkers is still limited. Ultra-high sensitive technology can help explain the heterogeneity in diagnostic performance.

AGEING RESEARCH REVIEWS (2021)

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Article Biophysics

In-situ fingerprinting phosphorylated proteins via surface-enhanced Raman spectroscopy: Single-site discrimination of Tau biomarkers in Alzheimer's disease

Hao Ma et al.

Summary: The presented method utilizes intrinsic Raman vibrational information of phosphorylated residues to develop an antibody and label-free approach for fingerprinting protein phosphorylation. Through surface-enhanced Raman scattering spectroscopy and an immobilized-metal affinity strategy, this ultrasensitive method can successfully discriminate single-site phosphorylated residues in proteins, demonstrating potential for both fundamental research and clinical applications.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Engineering, Biomedical

Evaluating effect of metallic ions on aggregation behavior of β-amyloid peptides by atomic force microscope and surface-enhanced Raman Scattering

Yang Xie et al.

Summary: The study successfully fabricated Aβ42 monolayers using a chemical self-assembled monolayer method, and found that the addition of metallic ions (Zn2+, Ca2+, Al3+) promoted aggregation events between Aβ42 molecules. This was monitored through atomic force microscopy and surface-enhanced Raman Scattering techniques.

BIOMEDICAL ENGINEERING ONLINE (2021)

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Article Chemistry, Physical

Convective Self-Assembly of 2D Nonclose-Packed Binary Au Nanoparticle Arrays with Tunable Optical Properties

Changchang Xing et al.

Summary: By modulating the convective self-assembly of colloidal nanoparticles on a templating NCP nanoparticle array, two-dimensional NCP binary Au nanoparticle arrays with tunable optical properties were constructed. The assembled arrays showed potential for applications in anti-counterfeiting measures.

CHEMISTRY OF MATERIALS (2021)

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Article Biophysics

Strategies to improve performances of LSPR biosensing: Structure, materials, and interface modification

Tianping Xu et al.

Summary: Due to the lower sensitivity of LSPR biosensors compared to other sensors, researchers have explored various methods to improve performance, including structural, material, and interface modifications. These efforts are expected to expand the applications of LSPR biosensing technology.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Nanoscience & Nanotechnology

SERS-Based Immunoassay Enhanced with Silver Probe for Selective Separation and Detection of Alzheimer's Disease Biomarkers

Dan Yu et al.

Summary: A novel SERS-based sandwich immunoassay was developed for quantitative detection of serum biomarkers A beta 1-42 and P-Tau-181, showing great potential for early diagnosis of Alzheimer's disease. The method exhibited favorable detection performance in protein standards and differentiated AD from non-AD dementia patients in clinical serum samples.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Multidisciplinary Sciences

Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures

Xin Dai et al.

Summary: Identifying protein structures at low concentrations is currently challenging. In this study, optical tweezers-coupled Raman spectroscopy is reported to produce tunable and reproducible SERS enhancements with single-molecule level sensitivity, and is used to detect protein structural features.

NATURE COMMUNICATIONS (2021)

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Article Biochemical Research Methods

Au/Ag composite-based SERS nanoprobe of Cr3+

Wendai Cheng et al.

Summary: The synthesized Au/Ag composite-based SERS nanoprobe showed significant advantages in sensitivity and response speed for quantitative characterization of Cr3+ content. This nanoprobe might offer a new strategy for dynamic monitoring of Cr3+ content in human metabolism.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2021)

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Article Neurosciences

Lipidomic Network of Mild Cognitive Impairment from the Mayo Clinic Study of Aging

Xuewei Wang et al.

Summary: This study identified seven lipids associated with mild cognitive impairment and revealed lipid species with stable correlations across conditions. Differential correlation analysis showed altered lipid correlations between cognitively unimpaired and MCI patients, as well as between patients with and without elevated brain amyloid, with 51 lipid pairs showing alterations by both cognitive status and brain amyloid. The central lipids in the network of these 51 pairs were not significantly associated with either MCI or amyloid, indicating network-based approaches provide additional biological insights.

JOURNAL OF ALZHEIMERS DISEASE (2021)

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Article Multidisciplinary Sciences

Specific detection of Staphylococcus aureus infection and marker for Alzheimer disease by surface enhanced Raman spectroscopy using silver and gold nanoparticle-coated magnetic polystyrene beads

Robert Prucek et al.

Summary: Utilizing a combination of Surface Enhanced Raman Spectroscopy (SERS) with streptavidin-biotin complex offers a promising alternative for rapid and effective disease therapy. This system, utilizing biotinylated antibodies, provides a powerful tool for various analytical applications, with a fast and easy-to-use preparation procedure for streptavidin coated magnetic polystyrene-Au (or Ag) nanocomposite particles.

SCIENTIFIC REPORTS (2021)

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Review Chemistry, Analytical

Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications

Bruno Miranda et al.

Summary: This review summarizes the latest research progress in flexible platforms for optical biosensors, focusing on localized surface plasmon resonance (LSPR) and surface-enhanced Raman spectroscopy (SERS)-based biosensors and discussing some of the current issues in the field. The study demonstrates the potential for large-scale, cost-effective plasmonic platforms and highlights the performance of hybrid nanomaterials and nanocomposites in comparison to traditional hard substrates.

BIOSENSORS-BASEL (2021)

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Article Chemistry, Multidisciplinary

Chiral Plasmonic Triangular Nanorings with SERS Activity for Ultrasensitive Detection of Amyloid Proteins in Alzheimer's Disease

Gaoyang Wang et al.

Summary: Chiral triangular gold nanorings fabricated with a wet-chemistry process exhibit strong optical activity and can effectively discriminate enantiomers. These nanorings are used for detecting Alzheimer's disease biomarkers with high sensitivity, allowing for early diagnosis.

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Review Biochemistry & Molecular Biology

Lipids and Alzheimer's Disease

Yu-Chia Kao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Step-by-step monitoring of a magnetic and SERS-active immunosensor assembly for purification and detection of tau protein

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JOURNAL OF BIOPHOTONICS (2020)

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Ultrasensitive amyloid β-protein quantification with high dynamic range using a hybrid graphene-gold surface-enhanced Raman spectroscopy platform

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Hybrid Three Dimensionally Printed Paper-Based Microfluidic Platform for Investigating a Cell's Apoptosis and Intracellular Cross-Talk

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Review Chemistry, Analytical

Development and application of analytical detection techniques for droplet -based micro fluidics-A review

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Article Chemistry, Analytical

Label-Free SERS Strategy for In Situ Monitoring and Real-Time Imaging of Aβ Aggregation Process in Live Neurons and Brain Tissues

Yan Zhou et al.

ANALYTICAL CHEMISTRY (2020)

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Review Chemistry, Analytical

Application of Microfluidic Chip Technology in Food Safety Sensing

Hongwei Gao et al.

SENSORS (2020)

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Carboxylic Acid-Functionalized, Graphitic Layer-Coated Three-Dimensional SERS Substrate for Label-Free Analysis of Alzheimer's Disease Biomarkers

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Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

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Rapid identification of alpha-fetoprotein in serum by a microfluidic SERS chip integrated with Ag/Au Nanocomposites

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Article Nanoscience & Nanotechnology

Biomacromolecular-Assembled Nanoclusters: Key Aspects for Robust Colloidal SERS Sensing

Roland P. M. Hoeller et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Cell Biology

RNA and Oxidative Stress in Alzheimer's Disease: Focus on microRNAs

Akihiko Nunomura et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Contributions of Molecular and Optical Techniques to the Clinical Diagnosis of Alzheimer's Disease

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Fiber-cap biosensors for SERS analysis of liquid samples

Caterina Credi et al.

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Plasma lipids metabolism in mild cognitive impairment and Alzheimer's disease

Alana C. Costa et al.

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Systemic and CNS Inflammation Crosstalk: Implications for Alzheimer's Disease

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CURRENT ALZHEIMER RESEARCH (2019)

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Reaction Kinetics-Mediated Control over Silver Nanogap Shells as Surface-Enhanced Raman Scattering Nanoprobes for Detection of Alzheimer's Disease Biomarkers

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SMALL (2019)

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Recent progress in the design fabrication of metal-organic frameworks-based nanozymes and their applications to sensing and cancer therapy

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Bifunctional Fluorescent/Raman Nanoprobe for the Early Detection of Amyloid

Yang Xia et al.

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Robust and Universal SERS Sensing Platform for Multiplexed Detection of Alzheimer's Disease Core Biomarkers Using PAapt-AuNPs Conjugates

Xue Zhang et al.

ACS SENSORS (2019)

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The neuropathological diagnosis of Alzheimer's disease

Michael A. DeTure et al.

MOLECULAR NEURODEGENERATION (2019)

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Magnetic nanoparticles in nanomedicine: a review of recent advances

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Targeting apolipoprotein E for treating Alzheimer's disease

Kelly R. Bales et al.

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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Justin M. Long et al.

CELL (2019)

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Label-free plasmonic biosensors for point-of-care diagnostics: a review

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EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2019)

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Multiplex biomarker approach to cardiovascular diseases

Michaela Adamcova et al.

ACTA PHARMACOLOGICA SINICA (2018)

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Optical assays based on colloidal inorganic nanoparticles

Amir Ghasemi et al.

ANALYST (2018)

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A general method for large-scale fabrication of Cu nanoislands/dragonfly wing SERS flexible substrates

Yuhong Wang et al.

CHINESE PHYSICS B (2018)

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Review Neurosciences

Alzheimer's Disease, Oligomers, and Inflammation

Gianluigi Forloni et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Au@p4VP core@shell pH-sensitive nanocomposites suitable for drug entrapment

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3D silver nanoparticles with multilayer graphene oxide as a spacer for surface enhanced Raman spectroscopy analysis

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NANOSCALE (2018)

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Sex differences in Alzheimer disease - the gateway to precision medicine

Maria Teresa Ferretti et al.

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Screening and multiple detection of cancer exosomes using an SERS-based method

Zhile Wang et al.

NANOSCALE (2018)

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Glia as architects of central nervous system formation and function

Nicola J. Allen et al.

SCIENCE (2018)

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Levels of plasma neurofilament light chain and cognitive function in patients with Alzheimer or Parkinson disease

Yung-Shuan Lin et al.

SCIENTIFIC REPORTS (2018)

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Alzheimer Disease: Perspectives from Epidemiology and Genetics

Jonathan L. Haines

JOURNAL OF LAW MEDICINE & ETHICS (2018)

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In Situ Monitoring the Aggregation Dynamics of Amyloid-β Protein Aβ42 in Physiological Media via a Raman-Based Frequency Shift Method

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Review Clinical Neurology

Synaptic degeneration and neurogranin in the pathophysiology of Alzheimer's disease

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EXPERT REVIEW OF NEUROTHERAPEUTICS (2017)

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Review Clinical Neurology

Synaptic degeneration and neurogranin in the pathophysiology of Alzheimer's disease

Simone Lista et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2017)

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Eric Tonnies et al.

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YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies

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Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer's disease core biomarkers in Lewy body disorders and Alzheimer's dementia

Davide Chiasserini et al.

ALZHEIMERS RESEARCH & THERAPY (2017)

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Review Clinical Neurology

Alzheimer's Disease: Biomarkers in the Genome, Blood, and Cerebrospinal Fluid

Rose Ann Huynh et al.

FRONTIERS IN NEUROLOGY (2017)

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Review Medicine, General & Internal

Cerebrospinal Fluid Biomarkers in Alzheimer's Disease-From Brain Starch to Bench and Bedside

Matthias Pawlowski et al.

DIAGNOSTICS (2017)

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Residential Bacteria on Surfaces in the Food Industry and Their Implications for Food Safety and Quality

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COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2017)

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Large-Area Au-Nanoparticle-Functionalized Si Nanorod Arrays for Spatially Uniform Surface-Enhanced Raman Spectroscopy

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Clinical-pathologic correlations in vascular cognitive impairment and dementia

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)

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CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

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LANCET NEUROLOGY (2016)

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On the critical role of Rayleigh scattering in single-molecule surface-enhanced Raman scattering via a plasmonic nanogap

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NANOSCALE (2016)

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Article Nanoscience & Nanotechnology

Hybrid Graphene Oxide Based Plasmonic-Magnetic Multifunctional Nanoplatform for Selective Separation and Label-Free Identification of Alzheimer's Disease Biomarkers

Teresa Demeritte et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

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Article Nanoscience & Nanotechnology

SERS Detection of Amyloid Oligomers on Metallorganic-Decorated Plasmonic Beads

Luca Guerrini et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

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Review Pathology

Genetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunities

Christiane Reitz

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2015)

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Article Multidisciplinary Sciences

Noble metal-comparable SERS enhancement from semiconducting metal oxides by making oxygen vacancies

Shan Cong et al.

NATURE COMMUNICATIONS (2015)

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Article Biochemical Research Methods

Statistically quantified measurement of an Alzheimer's marker by surface-enhanced Raman scattering

Ricardas Buividas et al.

JOURNAL OF BIOPHOTONICS (2015)

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Review Neurosciences

The Role of Visinin-Like Protein-1 in the Pathophysiology of Alzheimer's Disease

Magdalena Groblewska et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

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Developing novel blood-based biomarkers for Alzheimer's disease

Heather M. Snyder et al.

ALZHEIMERS & DEMENTIA (2014)

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Amyloid-β and Tau The Trigger and Bullet in Alzheimer Disease Pathogenesis

George S. Bloom

JAMA NEUROLOGY (2014)

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Off-Resonance Surface-Enhanced Raman Spectroscopy from Gold Nanorod Suspensions as a Function of Aspect Ratio: Not What We Thought

Sean T. Sivapalan et al.

ACS NANO (2013)

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Article Biochemistry & Molecular Biology

A SERS-Based Sandwich Assay for Ultrasensitive and Selective Detection of Alzheimer's Tau Protein

Adem Zengin et al.

BIOMACROMOLECULES (2013)

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Review Nanoscience & Nanotechnology

Raman spectroscopy as a versatile tool for studying the properties of graphene

Andrea C. Ferrari et al.

NATURE NANOTECHNOLOGY (2013)

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Ceramide and Apoptosis: Exploring the Enigmatic Connections between Sphingolipid Metabolism and Programmed Cell Death

Thomas D. Mullen et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2012)

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Review Chemistry, Multidisciplinary

Molecularly-mediated assemblies of plasmonic nanoparticles for Surface-Enhanced Raman Spectroscopy applications

Luca Guerrini et al.

CHEMICAL SOCIETY REVIEWS (2012)

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Article Chemistry, Physical

Quantitative Comparison of Raman Activities, SERS Activities, and SERS Enhancement Factors of Organothiols: Implication to Chemical Enhancement

Siyam M. Ansar et al.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2012)

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Review Biochemical Research Methods

Microfluidic designs and techniques using lab-on-a-chip devices for pathogen detection for point-of-care diagnostics

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LAB ON A CHIP (2012)

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Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

Alix de Calignon et al.

NEURON (2012)

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Review Chemistry, Multidisciplinary

Approaching the electromagnetic mechanism of surface-enhanced Raman scattering: from self-assembled arrays to individual gold nanoparticles

Lianming Tong et al.

CHEMICAL SOCIETY REVIEWS (2011)

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Increased CSF-BACE1 Activity Associated with Decreased Hippocampus Volume in Alzheimer's Disease

Michael Ewers et al.

JOURNAL OF ALZHEIMERS DISEASE (2011)

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Article Chemistry, Multidisciplinary

Fabrication of Gold Nanoparticle Modified ITO Substrate to Detect beta-Amyloid Using Surface-Enhanced Raman Scattering

Waleed Ahmed El-Said et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2011)

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Article Medicine, General & Internal

Alzheimer's disease

Clive Ballard et al.

LANCET (2011)

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Article Chemistry, Multidisciplinary

Raman Enhancement on Graphene: Adsorbed and Intercalated Molecular Species

Naeyoung Jung et al.

ACS NANO (2010)

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Review Clinical Neurology

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Clifford R. Jack et al.

LANCET NEUROLOGY (2010)

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Review Clinical Neurology

Classification and basic pathology of Alzheimer disease

Charles Duyckaerts et al.

ACTA NEUROPATHOLOGICA (2009)

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Article Clinical Neurology

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease

Wolfgang J. Streit et al.

ACTA NEUROPATHOLOGICA (2009)

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Editorial Material Multidisciplinary Sciences

NEUROSCIENCE Alzheimer's disease

Lennart Mucke

NATURE (2009)

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Review Nanoscience & Nanotechnology

Using nanoparticles to push the limits of detection

Nathan J. Wittenberg et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2009)

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Article Clinical Neurology

Distinct pools of β-amyloid in Alzheimer disease-affected brain -: A clinicopathologic study

Joshua R. Steinerman et al.

ARCHIVES OF NEUROLOGY (2008)

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Article Chemistry, Multidisciplinary

Nanofluidic biosensing for β-amyloid detection using surface enhanced Raman spectroscopy

I-Hsien Chou et al.

NANO LETTERS (2008)

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Review Biochemical Research Methods

Raman spectroscopy on transition metals

Bin Ren et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2007)

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Article Chemistry, Analytical

Microfluidic devices for environmental monitoring

L Marle et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2005)

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Article Chemistry, Physical

Wavelength-scanned surface-enhanced Raman excitation spectroscopy

AD McFarland et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2005)

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