SERS-Based Optical Nanobiosensors for the Detection of Alzheimer's Disease

Alzheimer's disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on surface-enhanced Raman scattering (SERS)-based biosensors, leveraging the excellent optical properties of nanomaterials to enhance detection performance. These highly sensitive and noninvasive biosensors offer opportunities for biomarker-driven clinical diagnostics and precision medicine. The review highlights various types of SERS-based biosensors targeting AD biomarkers, discussing their potential applications and contributions to AD diagnosis. Specific details about nanomaterials and targeted AD biomarkers are provided. Furthermore, the future research directions and challenges for improving AD marker detection using SERS sensors are outlined.

Automated summary

This review focuses on the application of surface-enhanced Raman scattering (SERS)-based biosensors in the diagnosis of Alzheimer's disease (AD). These biosensors leverage the optical properties of nanomaterials to enhance detection performance, offering high sensitivity and noninvasiveness. Different types of SERS sensors targeting AD biomarkers are discussed, and specific details regarding nanomaterials and AD biomarkers are provided. The future research directions and challenges for improving AD marker detection using SERS sensors are also outlined.