期刊
BIOSENSORS-BASEL
卷 13, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/bios13090855
关键词
alkaline phosphatase; electrochemical immunosensors; signal amplification; redox cycling; nanoparticles
Electrochemical immunosensors with alkaline phosphatase (ALP) as the signal reporter have shown great potential in various fields. This work summarizes the achievements of these immunosensors, focusing on detection principles, signal amplification strategies, and challenges for improving the performance of ALP-based immunoassays.
Electrochemical immunosensors have shown great potential in clinical diagnosis, food safety, environmental protection, and other fields. The feasible and innovative combination of enzyme catalysis and other signal-amplified elements has yielded exciting progress in the development of electrochemical immunosensors. Alkaline phosphatase (ALP) is one of the most popularly used enzyme reporters in bioassays. It has been widely utilized to design electrochemical immunosensors owing to its significant advantages (e.g., high catalytic activity, high turnover number, and excellent substrate specificity). In this work, we summarized the achievements of electrochemical immunosensors with ALP as the signal reporter. We mainly focused on detection principles and signal amplification strategies and briefly discussed the challenges regarding how to further improve the performance of ALP-based immunoassays.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据